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- W2131067243 endingPage "1847" @default.
- W2131067243 startingPage "1829" @default.
- W2131067243 abstract "Colorectal cancer (CRC) is frequently complicated by metastatic disease, with the liver being the most common site of metastasis. Surgical resection is the only realistic cure for colorectal liver metastases; however only 10-25% of cases are initially resectable. The introduction of combination chemotherapy has improved survival rates by enabling 10-20% cases with previously unresectable hepatic metastases to become amenable to surgery. Recent results with the biologic agent bevacizumab, a chimeric human-mouse monoclonal antibody against VEGF, and cetuximab, a chimeric human-mouse monoclonal antibody against EGF receptor, have shown that they improve clinical surgical outcomes when added to current first-line regimens in patients with metastatic colorectal cancer. Dual biologic therapy in combination with chemotherapy has, however, yielded disappointing results. Identification of biological markers is expected to help determine which patients are most likely to respond to these newer agents and thus improve targeted therapy." @default.
- W2131067243 created "2016-06-24" @default.
- W2131067243 creator A5032728807 @default.
- W2131067243 creator A5046514743 @default.
- W2131067243 creator A5048430335 @default.
- W2131067243 date "2009-12-01" @default.
- W2131067243 modified "2023-09-30" @default.
- W2131067243 title "Metastatic colorectal cancer: recent advances in its clinical management" @default.
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- W2131067243 doi "https://doi.org/10.1586/era.09.143" @default.
- W2131067243 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19954294" @default.
- W2131067243 hasPublicationYear "2009" @default.
- W2131067243 type Work @default.