Matches in SemOpenAlex for { <https://semopenalex.org/work/W2131069827> ?p ?o ?g. }
- W2131069827 endingPage "1797" @default.
- W2131069827 startingPage "1789" @default.
- W2131069827 abstract "We have compared the sensitivity of clonogenic interleukin 7 (IL-7)-dependent murine B cell precursors with that of clonogenic mature B cells and myeloid precursors to alpha-particles from plutonium-238 and X radiation. All three populations are relatively sensitive, but B cell precursors are ultrasensitive. This differential sensitivity is also observed with corticosteroid, etoposide, and cisplatin, all apoptosis-inducing drugs used in the treatment of leukemia and other cancers. Further, we show that x-rays and drugs induce the bulk of the B cell precursor population to undergo rapid apoptosis, despite the continued presence of IL-7. B cell precursors were found to express very low levels of BCL-2 protein compared with mature splenic B cells and their resistance to x-rays and corticosteroid could be enhanced by expression of a BCL-2 transgene. These data have important implications for normal lymphopoiesis and for the behavior of leukemic lymphoid precursor cells." @default.
- W2131069827 created "2016-06-24" @default.
- W2131069827 creator A5012198127 @default.
- W2131069827 creator A5023838985 @default.
- W2131069827 creator A5041051444 @default.
- W2131069827 creator A5059438505 @default.
- W2131069827 creator A5061167359 @default.
- W2131069827 creator A5067317405 @default.
- W2131069827 creator A5087016732 @default.
- W2131069827 creator A5089266223 @default.
- W2131069827 date "1994-06-01" @default.
- W2131069827 modified "2023-10-12" @default.
- W2131069827 title "Interleukin 7-dependent B lymphocyte precursor cells are ultrasensitive to apoptosis." @default.
- W2131069827 cites W138285015 @default.
- W2131069827 cites W140561711 @default.
- W2131069827 cites W1485476587 @default.
- W2131069827 cites W1556978242 @default.
- W2131069827 cites W1640887277 @default.
- W2131069827 cites W1898236813 @default.
- W2131069827 cites W1913179054 @default.
- W2131069827 cites W1944598762 @default.
- W2131069827 cites W1966899632 @default.
- W2131069827 cites W1970629830 @default.
- W2131069827 cites W1974260935 @default.
- W2131069827 cites W1978319003 @default.
- W2131069827 cites W1981373274 @default.
- W2131069827 cites W1986114734 @default.
- W2131069827 cites W1988335634 @default.
- W2131069827 cites W1995493920 @default.
- W2131069827 cites W2009603041 @default.
- W2131069827 cites W2013736266 @default.
- W2131069827 cites W2015632313 @default.
- W2131069827 cites W2028625808 @default.
- W2131069827 cites W2032592355 @default.
- W2131069827 cites W2037621441 @default.
- W2131069827 cites W2043066069 @default.
- W2131069827 cites W2043500928 @default.
- W2131069827 cites W2057257609 @default.
- W2131069827 cites W2063176993 @default.
- W2131069827 cites W2064508977 @default.
- W2131069827 cites W2067104437 @default.
- W2131069827 cites W2077708288 @default.
- W2131069827 cites W2085163546 @default.
- W2131069827 cites W2090265641 @default.
- W2131069827 cites W2112161923 @default.
- W2131069827 cites W2134979684 @default.
- W2131069827 cites W2140383812 @default.
- W2131069827 cites W2144808732 @default.
- W2131069827 cites W2146320943 @default.
- W2131069827 cites W2236639694 @default.
- W2131069827 cites W2407977596 @default.
- W2131069827 cites W2408870565 @default.
- W2131069827 cites W2470124325 @default.
- W2131069827 cites W26593026 @default.
- W2131069827 cites W3121869049 @default.
- W2131069827 cites W34249292 @default.
- W2131069827 doi "https://doi.org/10.1084/jem.179.6.1789" @default.
- W2131069827 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2191526" @default.
- W2131069827 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8195708" @default.
- W2131069827 hasPublicationYear "1994" @default.
- W2131069827 type Work @default.
- W2131069827 sameAs 2131069827 @default.
- W2131069827 citedByCount "58" @default.
- W2131069827 countsByYear W21310698272013 @default.
- W2131069827 countsByYear W21310698272016 @default.
- W2131069827 countsByYear W21310698272017 @default.
- W2131069827 countsByYear W21310698272019 @default.
- W2131069827 countsByYear W21310698272020 @default.
- W2131069827 countsByYear W21310698272022 @default.
- W2131069827 crossrefType "journal-article" @default.
- W2131069827 hasAuthorship W2131069827A5012198127 @default.
- W2131069827 hasAuthorship W2131069827A5023838985 @default.
- W2131069827 hasAuthorship W2131069827A5041051444 @default.
- W2131069827 hasAuthorship W2131069827A5059438505 @default.
- W2131069827 hasAuthorship W2131069827A5061167359 @default.
- W2131069827 hasAuthorship W2131069827A5067317405 @default.
- W2131069827 hasAuthorship W2131069827A5087016732 @default.
- W2131069827 hasAuthorship W2131069827A5089266223 @default.
- W2131069827 hasBestOaLocation W21310698271 @default.
- W2131069827 hasConcept C109159458 @default.
- W2131069827 hasConcept C117262875 @default.
- W2131069827 hasConcept C124964019 @default.
- W2131069827 hasConcept C1491633281 @default.
- W2131069827 hasConcept C153911025 @default.
- W2131069827 hasConcept C159654299 @default.
- W2131069827 hasConcept C185592680 @default.
- W2131069827 hasConcept C190283241 @default.
- W2131069827 hasConcept C203014093 @default.
- W2131069827 hasConcept C2776694085 @default.
- W2131069827 hasConcept C2777761686 @default.
- W2131069827 hasConcept C2778119113 @default.
- W2131069827 hasConcept C2778453870 @default.
- W2131069827 hasConcept C2779282312 @default.
- W2131069827 hasConcept C28328180 @default.
- W2131069827 hasConcept C2908647359 @default.
- W2131069827 hasConcept C502942594 @default.
- W2131069827 hasConcept C54355233 @default.
- W2131069827 hasConcept C55493867 @default.