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• W2131088832 abstract "Protein nanopores such as α-haemolysin and Mycobacterium smegmatis porin A (MspA) can be used to sequence long strands of DNA at low cost. To provide high-speed sequencing, large arrays of nanopores are required, but current nanopore sequencing methods rely on ionic current measurements from individually addressed pores and such methods are likely to prove difficult to scale up. Here we show that, by optically encoding the ionic flux through protein nanopores, the discrimination of nucleic acid sequences and the detection of sequence-specific nucleic acid hybridization events can be parallelized. We make optical recordings at a density of ∼104 nanopores per mm2 in a single droplet interface bilayer. Nanopore blockades can discriminate between DNAs with sub-picoampere equivalent resolution, and specific miRNA sequences can be identified by differences in unzipping kinetics. By creating an array of 2,500 bilayers with a micropatterned hydrogel chip, we are also able to load different samples into specific bilayers suitable for high-throughput nanopore recording. The discrimination of nucleic acid sequences and the detection of sequence-specific nucleic acid binding events by protein nanopores can be parallelized by optically encoding the ionic flux through the pores." @default.
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• W2131088832 date "2015-08-31" @default.
• W2131088832 modified "2023-09-30" @default.
• W2131088832 title "High-throughput optical sensing of nucleic acids in a nanopore array" @default.
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• W2131088832 doi "https://doi.org/10.1038/nnano.2015.189" @default.
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