Matches in SemOpenAlex for { <https://semopenalex.org/work/W2131095326> ?p ?o ?g. }
- W2131095326 abstract "Highly active antiretroviral therapy (HAART) has significantly improved the outcome and survival of human immunodeficiency virus (HIV)-infected patients. Subsequently, long-term morbidities including cancer have become of major public health and clinical interest for this patient population. Plasma cell disorders occur at higher incidence in HIV-infected patients; however, the molecular mechanisms driving the plasma cell disease process and the optimal management for these patients remain to be defined. This article provides an up-to-date review of the characteristics and management of HIV-infected patients with plasma cell disorders. We first present 3 cases of plasma cell disorders in HIV-infected patients, ranging from polyclonal hypergammaglobulinemia to symptomatic multiple myeloma. We then discuss the epidemiology, clinical presentation, and management of each of these plasma cell disorders, with an emphasis on the molecular events underlying the progression of plasma cell diseases from monoclonal gammopathy to symptomatic multiple myeloma. We propose a three-step hypothesis for the development of multiple myeloma. Finally, we discuss the use of high dose chemotherapy and autologous hematopoietic stem cell transplantation in the treatment of HIV-infected patients with multiple myeloma. Our review includes the care of HIV-infected patients with plasma cell disorders in the current era of HAART and novel agents available for the treatment of multiple myeloma." @default.
- W2131095326 created "2016-06-24" @default.
- W2131095326 creator A5008453908 @default.
- W2131095326 creator A5028733545 @default.
- W2131095326 creator A5040935781 @default.
- W2131095326 creator A5062190595 @default.
- W2131095326 date "2013-02-04" @default.
- W2131095326 modified "2023-10-16" @default.
- W2131095326 title "Plasma cell disorders in HIV-infected patients: epidemiology and molecular mechanisms" @default.
- W2131095326 cites W150506042 @default.
- W2131095326 cites W1517472403 @default.
- W2131095326 cites W162897767 @default.
- W2131095326 cites W1725655154 @default.
- W2131095326 cites W1727485877 @default.
- W2131095326 cites W1926331184 @default.
- W2131095326 cites W1963774766 @default.
- W2131095326 cites W1967958729 @default.
- W2131095326 cites W1968581194 @default.
- W2131095326 cites W1979385887 @default.
- W2131095326 cites W1980095186 @default.
- W2131095326 cites W1981847465 @default.
- W2131095326 cites W1982952122 @default.
- W2131095326 cites W1984164382 @default.
- W2131095326 cites W1984534203 @default.
- W2131095326 cites W1985304674 @default.
- W2131095326 cites W1986681533 @default.
- W2131095326 cites W1987039284 @default.
- W2131095326 cites W1988669425 @default.
- W2131095326 cites W1989996736 @default.
- W2131095326 cites W1997379399 @default.
- W2131095326 cites W1999323950 @default.
- W2131095326 cites W2000218963 @default.
- W2131095326 cites W2004465286 @default.
- W2131095326 cites W2005100560 @default.
- W2131095326 cites W2006680755 @default.
- W2131095326 cites W2006840099 @default.
- W2131095326 cites W2006891527 @default.
- W2131095326 cites W2008754795 @default.
- W2131095326 cites W2011738435 @default.
- W2131095326 cites W2012182672 @default.
- W2131095326 cites W2012582974 @default.
- W2131095326 cites W2016969330 @default.
- W2131095326 cites W2020965725 @default.
- W2131095326 cites W2021536610 @default.
- W2131095326 cites W2025969634 @default.
- W2131095326 cites W2028339433 @default.
- W2131095326 cites W2032058375 @default.
- W2131095326 cites W2037183248 @default.
- W2131095326 cites W2038477042 @default.
- W2131095326 cites W2040993067 @default.
- W2131095326 cites W2041369127 @default.
- W2131095326 cites W2041923700 @default.
- W2131095326 cites W2043002234 @default.
- W2131095326 cites W2043895762 @default.
- W2131095326 cites W2048064990 @default.
- W2131095326 cites W2051165614 @default.
- W2131095326 cites W2051372009 @default.
- W2131095326 cites W2051517030 @default.
- W2131095326 cites W2052337699 @default.
- W2131095326 cites W2055662838 @default.
- W2131095326 cites W2055680246 @default.
- W2131095326 cites W2057319734 @default.
- W2131095326 cites W2064210691 @default.
- W2131095326 cites W2065502963 @default.
- W2131095326 cites W2067680442 @default.
- W2131095326 cites W2068105766 @default.
- W2131095326 cites W2070957912 @default.
- W2131095326 cites W2071959000 @default.
- W2131095326 cites W2073821109 @default.
- W2131095326 cites W2074688366 @default.
- W2131095326 cites W2074978411 @default.
- W2131095326 cites W2076315217 @default.
- W2131095326 cites W2085039727 @default.
- W2131095326 cites W2086990334 @default.
- W2131095326 cites W2088929163 @default.
- W2131095326 cites W2092708620 @default.
- W2131095326 cites W2094833648 @default.
- W2131095326 cites W2097647692 @default.
- W2131095326 cites W2101035019 @default.
- W2131095326 cites W2104494161 @default.
- W2131095326 cites W2107571563 @default.
- W2131095326 cites W2119707919 @default.
- W2131095326 cites W2121411022 @default.
- W2131095326 cites W2121529973 @default.
- W2131095326 cites W2131180956 @default.
- W2131095326 cites W2135678986 @default.
- W2131095326 cites W2147071499 @default.
- W2131095326 cites W2148422519 @default.
- W2131095326 cites W2149877193 @default.
- W2131095326 cites W2155647946 @default.
- W2131095326 cites W2160088903 @default.
- W2131095326 cites W2164807675 @default.
- W2131095326 cites W2168628698 @default.
- W2131095326 cites W2170515647 @default.
- W2131095326 cites W2172021909 @default.
- W2131095326 cites W2261671195 @default.
- W2131095326 cites W2314302845 @default.
- W2131095326 cites W2315647475 @default.
- W2131095326 cites W2331150335 @default.
- W2131095326 cites W4211082074 @default.