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• W2131161781 startingPage "519" @default.
• W2131161781 abstract "Serial section electron microscopy of hemolysing erythrocytes (fixed at 12 s after the onset of osmotic hemolysis) revealed long slits and holes in the membrane, extending to around 1 µm in length. Many but not all of the slits and holes (about 100–1000 Å wide) were confluent with one another. Ferritin and colloidal gold (added after fixation) only permeated those cells containing membrane defects. No such large holes or slits were seen in saponin-treated erythrocytes, and the membrane was highly invaginated, giving the ghost a scalloped outline. Freeze-etch electron microscopy of saponin-treated membranes revealed 40–50 Å-wide pits in the extracellular surface of the membrane. If these pits represent regions from which cholesterol was extracted, then cholesterol is uniformly distributed over the entire erythrocyte membrane." @default.
• W2131161781 created "2016-06-24" @default.
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• W2131161781 date "1973-02-01" @default.
• W2131161781 modified "2023-10-14" @default.
• W2131161781 title "STRUCTURE OF MEMBRANE HOLES IN OSMOTIC AND SAPONIN HEMOLYSIS" @default.
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• W2131161781 doi "https://doi.org/10.1083/jcb.56.2.519" @default.
• W2131161781 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2108893" @default.
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