FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2131235503> ?p ?o ?g. }

• W2131235503 endingPage "125" @default.
• W2131235503 startingPage "112" @default.
• W2131235503 abstract "Non-homologous end joining (NHEJ) is critical for the maintenance of genetic integrity and DNA double-strand break (DSB) repair. NHEJ is regulated by a series of interactions between core components of the pathway, including Ku heterodimer, XLF/Cernunnos, and XRCC4/DNA Ligase 4 (Lig4). However, the mechanisms by which these proteins assemble into functional protein-DNA complexes are not fully understood. Here, we show that the von Willebrand (vWA) domain of Ku80 fulfills a critical role in this process by recruiting Aprataxin-and-PNK-Like Factor (APLF) into Ku-DNA complexes. APLF, in turn, functions as a scaffold protein and promotes the recruitment and/or retention of XRCC4-Lig4 and XLF, thereby assembling multi-protein Ku complexes capable of efficient DNA ligation in vitro and in cells. Disruption of the interactions between APLF and either Ku80 or XRCC4-Lig4 disrupts the assembly and activity of Ku complexes, and confers cellular hypersensitivity and reduced rates of chromosomal DSB repair in avian and human cells, respectively. Collectively, these data identify a role for the vWA domain of Ku80 and a molecular mechanism by which DNA ligase proficient complexes are assembled during NHEJ in mammalian cells, and reveal APLF to be a structural component of this critical DSB repair pathway." @default.
• W2131235503 created "2016-06-24" @default.
• W2131235503 creator A5008292868 @default.
• W2131235503 creator A5011271805 @default.
• W2131235503 creator A5013928672 @default.
• W2131235503 creator A5037200778 @default.
• W2131235503 creator A5042269275 @default.
• W2131235503 creator A5058322347 @default.
• W2131235503 creator A5061096239 @default.
• W2131235503 creator A5072834550 @default.
• W2131235503 date "2012-11-23" @default.
• W2131235503 modified "2023-09-23" @default.
• W2131235503 title "APLF promotes the assembly and activity of non-homologous end joining protein complexes" @default.
• W2131235503 cites W1897299346 @default.
• W2131235503 cites W1940074648 @default.
• W2131235503 cites W1963613246 @default.
• W2131235503 cites W1984886867 @default.
• W2131235503 cites W1985363523 @default.
• W2131235503 cites W1985643620 @default.
• W2131235503 cites W1997576768 @default.
• W2131235503 cites W2000438077 @default.
• W2131235503 cites W2001784394 @default.
• W2131235503 cites W2004575615 @default.
• W2131235503 cites W2007369689 @default.
• W2131235503 cites W2011522975 @default.
• W2131235503 cites W2013580891 @default.
• W2131235503 cites W2025572488 @default.
• W2131235503 cites W2028716923 @default.
• W2131235503 cites W2038596673 @default.
• W2131235503 cites W2049018115 @default.
• W2131235503 cites W2061015483 @default.
• W2131235503 cites W2064588859 @default.
• W2131235503 cites W2066360668 @default.
• W2131235503 cites W2070395126 @default.
• W2131235503 cites W2075351905 @default.
• W2131235503 cites W2075758387 @default.
• W2131235503 cites W2079891276 @default.
• W2131235503 cites W2085422820 @default.
• W2131235503 cites W2104844303 @default.
• W2131235503 cites W2109272669 @default.
• W2131235503 cites W2113195616 @default.
• W2131235503 cites W2116050965 @default.
• W2131235503 cites W2116343025 @default.
• W2131235503 cites W2116718924 @default.
• W2131235503 cites W2117529453 @default.
• W2131235503 cites W2118623636 @default.
• W2131235503 cites W2119371129 @default.
• W2131235503 cites W2121070277 @default.
• W2131235503 cites W2124215787 @default.
• W2131235503 cites W2126295754 @default.
• W2131235503 cites W2135735491 @default.
• W2131235503 cites W2145200068 @default.
• W2131235503 cites W2147477441 @default.
• W2131235503 cites W2148191984 @default.
• W2131235503 cites W2162412306 @default.
• W2131235503 cites W2164995160 @default.
• W2131235503 doi "https://doi.org/10.1038/emboj.2012.304" @default.
• W2131235503 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3545299" @default.
• W2131235503 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23178593" @default.
• W2131235503 hasPublicationYear "2012" @default.
• W2131235503 type Work @default.
• W2131235503 sameAs 2131235503 @default.
• W2131235503 citedByCount "123" @default.
• W2131235503 countsByYear W21312355032013 @default.
• W2131235503 countsByYear W21312355032014 @default.
• W2131235503 countsByYear W21312355032015 @default.
• W2131235503 countsByYear W21312355032016 @default.
• W2131235503 countsByYear W21312355032017 @default.
• W2131235503 countsByYear W21312355032018 @default.
• W2131235503 countsByYear W21312355032019 @default.
• W2131235503 countsByYear W21312355032020 @default.
• W2131235503 countsByYear W21312355032021 @default.
• W2131235503 countsByYear W21312355032022 @default.
• W2131235503 countsByYear W21312355032023 @default.
• W2131235503 crossrefType "journal-article" @default.
• W2131235503 hasAuthorship W2131235503A5008292868 @default.
• W2131235503 hasAuthorship W2131235503A5011271805 @default.
• W2131235503 hasAuthorship W2131235503A5013928672 @default.
• W2131235503 hasAuthorship W2131235503A5037200778 @default.
• W2131235503 hasAuthorship W2131235503A5042269275 @default.
• W2131235503 hasAuthorship W2131235503A5058322347 @default.
• W2131235503 hasAuthorship W2131235503A5061096239 @default.
• W2131235503 hasAuthorship W2131235503A5072834550 @default.
• W2131235503 hasBestOaLocation W21312355032 @default.
• W2131235503 hasConcept C102744134 @default.
• W2131235503 hasConcept C104317684 @default.
• W2131235503 hasConcept C104451858 @default.
• W2131235503 hasConcept C122917832 @default.
• W2131235503 hasConcept C134459356 @default.
• W2131235503 hasConcept C134935766 @default.
• W2131235503 hasConcept C145803527 @default.
• W2131235503 hasConcept C175114707 @default.
• W2131235503 hasConcept C193104389 @default.
• W2131235503 hasConcept C25602115 @default.
• W2131235503 hasConcept C2780919815 @default.
• W2131235503 hasConcept C54355233 @default.
• W2131235503 hasConcept C552990157 @default.
• W2131235503 hasConcept C86339819 @default.

• next