FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2131255863> ?p ?o ?g. }

• W2131255863 endingPage "407" @default.
• W2131255863 startingPage "399" @default.
• W2131255863 abstract "Injured tendons require mechanical tension for optimal healing, but it is unclear which genes are upregulated and responsible for this effect. We unloaded one Achilles tendon in rats by Botox injections in the calf muscles. The tendon was then transected and left to heal. We studied mechanical properties of the tendon calluses, as well as mRNA expression, and compared them with loaded controls. Tendon calluses were studied 3, 8, 14, and 21 days after transection. Intact tendons were studied similarly for comparison. Altogether 110 rats were used. The genes were chosen for proteins marking inflammation, growth, extracellular matrix, and tendon specificity. In intact tendons, procollagen III and tenascin-C were more expressed in loaded than unloaded tendons, but none of the other genes was affected. In healing tendons, loading status had small effects on the selected genes. However, TNF-α transforming growth factor-β1, and procollagens I and III were less expressed in loaded callus tissue at day 3. At day 8 procollagens I and III, lysyl oxidase, and scleraxis had a lower expression in loaded calluses. However, by days 14 and 21, procollagen I, cartilage oligomeric matrix protein, tenascin-C, tenomodulin, and scleraxis were all more expressed in loaded calluses. In healing tendons, the transverse area was larger in loaded samples, but material properties were unaffected, or even impaired. Thus mechanical loading is important for growth of the callus but not its mechanical quality. The main effect of loading during healing might thereby be sought among growth stimulators. In the late phase of healing, tendon-specific genes (scleraxis and tenomodulin) were upregulated with loading, and the healing tissue might to some extent represent a regenerate rather than a scar." @default.
• W2131255863 created "2016-06-24" @default.
• W2131255863 creator A5014258435 @default.
• W2131255863 creator A5070073048 @default.
• W2131255863 creator A5091374536 @default.
• W2131255863 date "2009-08-01" @default.
• W2131255863 modified "2023-10-15" @default.
• W2131255863 title "Rat Achilles tendon healing: mechanical loading and gene expression" @default.
• W2131255863 cites W1527619287 @default.
• W2131255863 cites W1597537902 @default.
• W2131255863 cites W1967542988 @default.
• W2131255863 cites W1969366516 @default.
• W2131255863 cites W1971065897 @default.
• W2131255863 cites W1985611232 @default.
• W2131255863 cites W1988897858 @default.
• W2131255863 cites W1990475130 @default.
• W2131255863 cites W1995080334 @default.
• W2131255863 cites W1995383666 @default.
• W2131255863 cites W1997137576 @default.
• W2131255863 cites W2001650412 @default.
• W2131255863 cites W2005039840 @default.
• W2131255863 cites W2008414056 @default.
• W2131255863 cites W2016263786 @default.
• W2131255863 cites W2016658684 @default.
• W2131255863 cites W2030012902 @default.
• W2131255863 cites W2041518387 @default.
• W2131255863 cites W2065536055 @default.
• W2131255863 cites W2077768597 @default.
• W2131255863 cites W2086135781 @default.
• W2131255863 cites W2089273131 @default.
• W2131255863 cites W2100044667 @default.
• W2131255863 cites W2105611128 @default.
• W2131255863 cites W2120002085 @default.
• W2131255863 cites W2120488253 @default.
• W2131255863 cites W2125481886 @default.
• W2131255863 cites W2140058803 @default.
• W2131255863 cites W2168681970 @default.
• W2131255863 cites W2169290979 @default.
• W2131255863 cites W2172048917 @default.
• W2131255863 cites W2404271118 @default.
• W2131255863 doi "https://doi.org/10.1152/japplphysiol.91563.2008" @default.
• W2131255863 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19541731" @default.
• W2131255863 hasPublicationYear "2009" @default.
• W2131255863 type Work @default.
• W2131255863 sameAs 2131255863 @default.
• W2131255863 citedByCount "130" @default.
• W2131255863 countsByYear W21312558632012 @default.
• W2131255863 countsByYear W21312558632013 @default.
• W2131255863 countsByYear W21312558632014 @default.
• W2131255863 countsByYear W21312558632015 @default.
• W2131255863 countsByYear W21312558632016 @default.
• W2131255863 countsByYear W21312558632017 @default.
• W2131255863 countsByYear W21312558632018 @default.
• W2131255863 countsByYear W21312558632019 @default.
• W2131255863 countsByYear W21312558632020 @default.
• W2131255863 countsByYear W21312558632021 @default.
• W2131255863 countsByYear W21312558632022 @default.
• W2131255863 countsByYear W21312558632023 @default.
• W2131255863 crossrefType "journal-article" @default.
• W2131255863 hasAuthorship W2131255863A5014258435 @default.
• W2131255863 hasAuthorship W2131255863A5070073048 @default.
• W2131255863 hasAuthorship W2131255863A5091374536 @default.
• W2131255863 hasConcept C104317684 @default.
• W2131255863 hasConcept C105702510 @default.
• W2131255863 hasConcept C117961784 @default.
• W2131255863 hasConcept C134018914 @default.
• W2131255863 hasConcept C150194340 @default.
• W2131255863 hasConcept C171056886 @default.
• W2131255863 hasConcept C185592680 @default.
• W2131255863 hasConcept C189165786 @default.
• W2131255863 hasConcept C193143273 @default.
• W2131255863 hasConcept C203014093 @default.
• W2131255863 hasConcept C2779797417 @default.
• W2131255863 hasConcept C2780105995 @default.
• W2131255863 hasConcept C2780269544 @default.
• W2131255863 hasConcept C2780550940 @default.
• W2131255863 hasConcept C2780984734 @default.
• W2131255863 hasConcept C55493867 @default.
• W2131255863 hasConcept C64348721 @default.
• W2131255863 hasConcept C86803240 @default.
• W2131255863 hasConcept C95444343 @default.
• W2131255863 hasConceptScore W2131255863C104317684 @default.
• W2131255863 hasConceptScore W2131255863C105702510 @default.
• W2131255863 hasConceptScore W2131255863C117961784 @default.
• W2131255863 hasConceptScore W2131255863C134018914 @default.
• W2131255863 hasConceptScore W2131255863C150194340 @default.
• W2131255863 hasConceptScore W2131255863C171056886 @default.
• W2131255863 hasConceptScore W2131255863C185592680 @default.
• W2131255863 hasConceptScore W2131255863C189165786 @default.
• W2131255863 hasConceptScore W2131255863C193143273 @default.
• W2131255863 hasConceptScore W2131255863C203014093 @default.
• W2131255863 hasConceptScore W2131255863C2779797417 @default.
• W2131255863 hasConceptScore W2131255863C2780105995 @default.
• W2131255863 hasConceptScore W2131255863C2780269544 @default.
• W2131255863 hasConceptScore W2131255863C2780550940 @default.
• W2131255863 hasConceptScore W2131255863C2780984734 @default.
• W2131255863 hasConceptScore W2131255863C55493867 @default.
• W2131255863 hasConceptScore W2131255863C64348721 @default.

• next