FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2131274872> ?p ?o ?g. }

• W2131274872 endingPage "17402" @default.
• W2131274872 startingPage "17397" @default.
• W2131274872 abstract "The pancreatic secretagogue cholecystokinin (CCK) is widely thought to stimulate enzyme secretion by acinar cells indirectly via activation of the vagus nerve. We postulate an alternative pathway for CCK-induced pancreatic secretion. We hypothesize that neurally related pancreatic stellate cells (PSCs; located in close proximity to the basolateral aspect of acinar cells) play a regulatory role in pancreatic secretion by serving as an intermediate target for CCK and secreting the neurotransmitter acetylcholine (ACh), which, in turn, stimulates acinar enzyme secretion. To determine whether PSCs ( i ) exhibit CCK-dependent ACh secretion and ( ii ) influence acinar enzyme secretion, primary cultures of human and rat PSCs were used. Immunoblotting and/or immunofluorescence was used to detect choline acetyltransferase (ACh synthesizing enzyme), vesicular ACh transporter (VAChT), synaptophysin, and CCK receptors 1 and 2. Synaptic-like vesicles in PSCs were identified by EM. ACh secretion by PSCs exposed to 20 pM CCK was measured by LC-MS/MS. Amylase secretion by acini [pretreated with and without the muscarinic receptor antagonist atropine (10 μM) and cocultured with PSCs] was measured by colorimetry. PSCs express ACh synthesizing enzyme, VAChT, synaptophysin, and CCK receptors; exhibit CCK-dependent ACh secretion; and stimulate amylase secretion by acini, which is blocked by atropine. In conclusion, PSCs express the essential elements for ACh synthesis and secretion. CCK stimulates ACh secretion by PSCs, which, in turn, induces amylase secretion by acini. Therefore, PSCs may represent a previously unrecognized intrapancreatic pathway regulating CCK-induced pancreatic exocrine secretion." @default.
• W2131274872 created "2016-06-24" @default.
• W2131274872 creator A5006732921 @default.
• W2131274872 creator A5012096834 @default.
• W2131274872 creator A5014201180 @default.
• W2131274872 creator A5036796175 @default.
• W2131274872 creator A5037908893 @default.
• W2131274872 creator A5054756817 @default.
• W2131274872 creator A5055335553 @default.
• W2131274872 creator A5056263381 @default.
• W2131274872 creator A5061823428 @default.
• W2131274872 creator A5077529397 @default.
• W2131274872 creator A5078160208 @default.
• W2131274872 creator A5079752841 @default.
• W2131274872 date "2010-09-17" @default.
• W2131274872 modified "2023-10-15" @default.
• W2131274872 title "Pancreatic stellate cells produce acetylcholine and may play a role in pancreatic exocrine secretion" @default.
• W2131274872 cites W1497506244 @default.
• W2131274872 cites W1892125219 @default.
• W2131274872 cites W1935132610 @default.
• W2131274872 cites W1981160078 @default.
• W2131274872 cites W1985780641 @default.
• W2131274872 cites W1989732890 @default.
• W2131274872 cites W1993762779 @default.
• W2131274872 cites W1998114329 @default.
• W2131274872 cites W1999249081 @default.
• W2131274872 cites W2012244863 @default.
• W2131274872 cites W2013064129 @default.
• W2131274872 cites W2018225189 @default.
• W2131274872 cites W2031966175 @default.
• W2131274872 cites W2040157384 @default.
• W2131274872 cites W2048465541 @default.
• W2131274872 cites W2072943291 @default.
• W2131274872 cites W2080801486 @default.
• W2131274872 cites W2080963091 @default.
• W2131274872 cites W2104416279 @default.
• W2131274872 cites W2106165977 @default.
• W2131274872 cites W2113777848 @default.
• W2131274872 cites W2114058430 @default.
• W2131274872 cites W2144869905 @default.
• W2131274872 cites W2150437164 @default.
• W2131274872 cites W2153029682 @default.
• W2131274872 cites W2159172675 @default.
• W2131274872 cites W2168845626 @default.
• W2131274872 cites W3022748635 @default.
• W2131274872 doi "https://doi.org/10.1073/pnas.1000359107" @default.
• W2131274872 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2951425" @default.
• W2131274872 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20852067" @default.
• W2131274872 hasPublicationYear "2010" @default.
• W2131274872 type Work @default.
• W2131274872 sameAs 2131274872 @default.
• W2131274872 citedByCount "87" @default.
• W2131274872 countsByYear W21312748722012 @default.
• W2131274872 countsByYear W21312748722013 @default.
• W2131274872 countsByYear W21312748722014 @default.
• W2131274872 countsByYear W21312748722015 @default.
• W2131274872 countsByYear W21312748722016 @default.
• W2131274872 countsByYear W21312748722017 @default.
• W2131274872 countsByYear W21312748722018 @default.
• W2131274872 countsByYear W21312748722019 @default.
• W2131274872 countsByYear W21312748722020 @default.
• W2131274872 countsByYear W21312748722021 @default.
• W2131274872 countsByYear W21312748722022 @default.
• W2131274872 countsByYear W21312748722023 @default.
• W2131274872 crossrefType "journal-article" @default.
• W2131274872 hasAuthorship W2131274872A5006732921 @default.
• W2131274872 hasAuthorship W2131274872A5012096834 @default.
• W2131274872 hasAuthorship W2131274872A5014201180 @default.
• W2131274872 hasAuthorship W2131274872A5036796175 @default.
• W2131274872 hasAuthorship W2131274872A5037908893 @default.
• W2131274872 hasAuthorship W2131274872A5054756817 @default.
• W2131274872 hasAuthorship W2131274872A5055335553 @default.
• W2131274872 hasAuthorship W2131274872A5056263381 @default.
• W2131274872 hasAuthorship W2131274872A5061823428 @default.
• W2131274872 hasAuthorship W2131274872A5077529397 @default.
• W2131274872 hasAuthorship W2131274872A5078160208 @default.
• W2131274872 hasAuthorship W2131274872A5079752841 @default.
• W2131274872 hasBestOaLocation W21312748721 @default.
• W2131274872 hasConcept C116289061 @default.
• W2131274872 hasConcept C126322002 @default.
• W2131274872 hasConcept C134018914 @default.
• W2131274872 hasConcept C170493617 @default.
• W2131274872 hasConcept C185592680 @default.
• W2131274872 hasConcept C22885893 @default.
• W2131274872 hasConcept C2775910092 @default.
• W2131274872 hasConcept C2777593968 @default.
• W2131274872 hasConcept C2778764654 @default.
• W2131274872 hasConcept C2780161494 @default.
• W2131274872 hasConcept C2780446580 @default.
• W2131274872 hasConcept C32110497 @default.
• W2131274872 hasConcept C33789571 @default.
• W2131274872 hasConcept C49039625 @default.
• W2131274872 hasConcept C71924100 @default.
• W2131274872 hasConcept C86803240 @default.
• W2131274872 hasConceptScore W2131274872C116289061 @default.
• W2131274872 hasConceptScore W2131274872C126322002 @default.
• W2131274872 hasConceptScore W2131274872C134018914 @default.
• W2131274872 hasConceptScore W2131274872C170493617 @default.

• next