Matches in SemOpenAlex for { <https://semopenalex.org/work/W2131282078> ?p ?o ?g. }
- W2131282078 endingPage "726" @default.
- W2131282078 startingPage "713" @default.
- W2131282078 abstract "Large numbers of new neurons are born continuously in the adult subventricular zone (SVZ). The molecular niche of SVZ stem cells is poorly understood. Here, we show that the bone morphogenetic protein (BMP) antagonist Noggin is expressed by ependymal cells adjacent to the SVZ. SVZ cells were found to express BMPs as well as their cognate receptors. BMPs potently inhibited neurogenesis both in vitro and in vivo. BMP signaling cell-autonomously blocked the production of neurons by SVZ precursors by directing glial differentiation. Purified mouse Noggin protein promoted neurogenesis in vitro and inhibited glial cell differentiation. Ectopic Noggin promoted neuronal differentiation of SVZ cells grafted to the striatum. We thus propose that ependymal Noggin production creates a neurogenic environment in the adjacent SVZ by blocking endogenous BMP signaling." @default.
- W2131282078 created "2016-06-24" @default.
- W2131282078 creator A5000638202 @default.
- W2131282078 creator A5015217389 @default.
- W2131282078 creator A5031779232 @default.
- W2131282078 creator A5032005977 @default.
- W2131282078 creator A5060253376 @default.
- W2131282078 creator A5082818161 @default.
- W2131282078 date "2000-12-01" @default.
- W2131282078 modified "2023-10-18" @default.
- W2131282078 title "Noggin Antagonizes BMP Signaling to Create a Niche for Adult Neurogenesis" @default.
- W2131282078 cites W1485371658 @default.
- W2131282078 cites W1487914405 @default.
- W2131282078 cites W1542222934 @default.
- W2131282078 cites W1572000449 @default.
- W2131282078 cites W1575310353 @default.
- W2131282078 cites W1657005131 @default.
- W2131282078 cites W1733539716 @default.
- W2131282078 cites W1859730138 @default.
- W2131282078 cites W1919667732 @default.
- W2131282078 cites W1965641543 @default.
- W2131282078 cites W1966215328 @default.
- W2131282078 cites W1970168335 @default.
- W2131282078 cites W1977640628 @default.
- W2131282078 cites W1982248825 @default.
- W2131282078 cites W1983725263 @default.
- W2131282078 cites W1984288177 @default.
- W2131282078 cites W1985244709 @default.
- W2131282078 cites W1986595328 @default.
- W2131282078 cites W1987386868 @default.
- W2131282078 cites W1989389324 @default.
- W2131282078 cites W1989722096 @default.
- W2131282078 cites W1990938412 @default.
- W2131282078 cites W1994412624 @default.
- W2131282078 cites W1996701541 @default.
- W2131282078 cites W1996907803 @default.
- W2131282078 cites W2002686876 @default.
- W2131282078 cites W2003861928 @default.
- W2131282078 cites W2007242343 @default.
- W2131282078 cites W2012295730 @default.
- W2131282078 cites W2014891548 @default.
- W2131282078 cites W2024279589 @default.
- W2131282078 cites W2025201512 @default.
- W2131282078 cites W2030508161 @default.
- W2131282078 cites W2033904138 @default.
- W2131282078 cites W2035250926 @default.
- W2131282078 cites W2039396493 @default.
- W2131282078 cites W2040027102 @default.
- W2131282078 cites W2043505498 @default.
- W2131282078 cites W2043622238 @default.
- W2131282078 cites W2047165320 @default.
- W2131282078 cites W2051364110 @default.
- W2131282078 cites W2051575011 @default.
- W2131282078 cites W2060041183 @default.
- W2131282078 cites W2060633883 @default.
- W2131282078 cites W2067161293 @default.
- W2131282078 cites W2078623299 @default.
- W2131282078 cites W2079356804 @default.
- W2131282078 cites W2080931209 @default.
- W2131282078 cites W2084652820 @default.
- W2131282078 cites W2090778914 @default.
- W2131282078 cites W2092911887 @default.
- W2131282078 cites W2101294380 @default.
- W2131282078 cites W2103031848 @default.
- W2131282078 cites W2103600292 @default.
- W2131282078 cites W2111121844 @default.
- W2131282078 cites W2112393462 @default.
- W2131282078 cites W2115438940 @default.
- W2131282078 cites W2123957194 @default.
- W2131282078 cites W2129261595 @default.
- W2131282078 cites W2139208934 @default.
- W2131282078 cites W2145235967 @default.
- W2131282078 cites W2148459495 @default.
- W2131282078 cites W2148965620 @default.
- W2131282078 cites W2154104720 @default.
- W2131282078 cites W2155639900 @default.
- W2131282078 cites W2160280025 @default.
- W2131282078 cites W2163513779 @default.
- W2131282078 cites W2165867905 @default.
- W2131282078 cites W4239583753 @default.
- W2131282078 doi "https://doi.org/10.1016/s0896-6273(00)00148-3" @default.
- W2131282078 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11163261" @default.
- W2131282078 hasPublicationYear "2000" @default.
- W2131282078 type Work @default.
- W2131282078 sameAs 2131282078 @default.
- W2131282078 citedByCount "1010" @default.
- W2131282078 countsByYear W21312820782012 @default.
- W2131282078 countsByYear W21312820782013 @default.
- W2131282078 countsByYear W21312820782014 @default.
- W2131282078 countsByYear W21312820782015 @default.
- W2131282078 countsByYear W21312820782016 @default.
- W2131282078 countsByYear W21312820782017 @default.
- W2131282078 countsByYear W21312820782018 @default.
- W2131282078 countsByYear W21312820782019 @default.
- W2131282078 countsByYear W21312820782020 @default.
- W2131282078 countsByYear W21312820782021 @default.
- W2131282078 countsByYear W21312820782022 @default.
- W2131282078 countsByYear W21312820782023 @default.