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• W2131284518 abstract "G protein-coupled receptors (GPCRs) are essential components of cellular signaling pathways. They are the targets of many current pharmaceuticals and are postulated to dimerize or oligomerize in cellular membranes in conjunction with their functional mechanisms. We demonstrate using fluorescence resonance energy transfer how association of rhodopsin occurs by long-range lipid-protein interactions due to geometrical forces, yielding greater receptor crowding. Constitutive association of rhodopsin is promoted by a reduction in membrane thickness (hydrophobic mismatch), but also by an increase in protein/lipid molar ratio, showing the importance of interactions extending well beyond a single annulus of boundary lipids. The fluorescence data correlate with the pKa for the MI-to-MII transition of rhodopsin, where deprotonation of the retinylidene Schiff base occurs in conjunction with helical movements leading to activation of the photoreceptor. A more dispersed membrane environment optimizes formation of the MII conformation that results in visual function. A flexible surface model explains both the dispersal and activation of rhodopsin in terms of bilayer curvature deformation (strain) and hydrophobic solvation energy. The bilayer stress is related to the lateral pressure profile in terms of the spontaneous curvature and associated bending rigidity. Transduction of the strain energy (frustration) of the bilayer drives protein oligomerization and conformational changes in a coupled manner. Our findings illuminate the physical principles of membrane protein association due to chemically nonspecific interactions in fluid lipid bilayers. Moreover, they yield a conceptual framework for understanding how the tightly regulated lipid compositions of cellular membranes influence their protein-mediated functions." @default.
• W2131284518 created "2016-06-24" @default.
• W2131284518 creator A5005781724 @default.
• W2131284518 creator A5046786993 @default.
• W2131284518 creator A5076220039 @default.
• W2131284518 creator A5085328052 @default.
• W2131284518 date "2006-12-01" @default.
• W2131284518 modified "2023-10-14" @default.
• W2131284518 title "Curvature and Hydrophobic Forces Drive Oligomerization and Modulate Activity of Rhodopsin in Membranes" @default.
• W2131284518 cites W1595449036 @default.
• W2131284518 cites W1603274157 @default.
• W2131284518 cites W1736189198 @default.
• W2131284518 cites W1966039751 @default.
• W2131284518 cites W1967741078 @default.
• W2131284518 cites W1973056305 @default.
• W2131284518 cites W1974141214 @default.
• W2131284518 cites W1979194254 @default.
• W2131284518 cites W1981211418 @default.
• W2131284518 cites W1986402769 @default.
• W2131284518 cites W1986665610 @default.
• W2131284518 cites W1989171306 @default.
• W2131284518 cites W1989475934 @default.
• W2131284518 cites W1993697025 @default.
• W2131284518 cites W1993813725 @default.
• W2131284518 cites W1994249027 @default.
• W2131284518 cites W1994831969 @default.
• W2131284518 cites W1994876448 @default.
• W2131284518 cites W1996795941 @default.
• W2131284518 cites W1998423869 @default.
• W2131284518 cites W1999698653 @default.
• W2131284518 cites W2005630761 @default.
• W2131284518 cites W2005798169 @default.
• W2131284518 cites W2007195248 @default.
• W2131284518 cites W2007483105 @default.
• W2131284518 cites W2008305695 @default.
• W2131284518 cites W2011396491 @default.
• W2131284518 cites W2016028680 @default.
• W2131284518 cites W2016713175 @default.
• W2131284518 cites W2019074781 @default.
• W2131284518 cites W2019373008 @default.
• W2131284518 cites W2021517093 @default.
• W2131284518 cites W2021882008 @default.
• W2131284518 cites W2023948167 @default.
• W2131284518 cites W2026777794 @default.
• W2131284518 cites W2037664056 @default.
• W2131284518 cites W2037784258 @default.
• W2131284518 cites W2037834475 @default.
• W2131284518 cites W2038537866 @default.
• W2131284518 cites W2044092676 @default.
• W2131284518 cites W2049869893 @default.
• W2131284518 cites W2050880321 @default.
• W2131284518 cites W2052200245 @default.
• W2131284518 cites W2052717453 @default.
• W2131284518 cites W2053613303 @default.
• W2131284518 cites W2053762197 @default.
• W2131284518 cites W2056408911 @default.
• W2131284518 cites W2056618526 @default.
• W2131284518 cites W2061133720 @default.
• W2131284518 cites W2064154273 @default.
• W2131284518 cites W2064554902 @default.
• W2131284518 cites W2067104956 @default.
• W2131284518 cites W2069790681 @default.
• W2131284518 cites W2069966083 @default.
• W2131284518 cites W2072030765 @default.
• W2131284518 cites W2072073925 @default.
• W2131284518 cites W2072167784 @default.
• W2131284518 cites W2073539198 @default.
• W2131284518 cites W2076228202 @default.
• W2131284518 cites W2078481695 @default.
• W2131284518 cites W2078856946 @default.
• W2131284518 cites W2079205673 @default.
• W2131284518 cites W2083637735 @default.
• W2131284518 cites W2089090006 @default.
• W2131284518 cites W2091615898 @default.
• W2131284518 cites W2097365951 @default.
• W2131284518 cites W2099310340 @default.
• W2131284518 cites W2100452328 @default.
• W2131284518 cites W2101749921 @default.
• W2131284518 cites W2103730192 @default.
• W2131284518 cites W2103908315 @default.
• W2131284518 cites W2113183595 @default.
• W2131284518 cites W2117611274 @default.
• W2131284518 cites W2118950099 @default.
• W2131284518 cites W2120504835 @default.
• W2131284518 cites W2121298951 @default.
• W2131284518 cites W2121568234 @default.
• W2131284518 cites W2122844011 @default.
• W2131284518 cites W2122882997 @default.
• W2131284518 cites W2124329888 @default.
• W2131284518 cites W2128628166 @default.
• W2131284518 cites W2132033525 @default.
• W2131284518 cites W2136259733 @default.
• W2131284518 cites W2137714679 @default.
• W2131284518 cites W2140704050 @default.
• W2131284518 cites W2142083551 @default.
• W2131284518 cites W2147613694 @default.
• W2131284518 cites W2148982907 @default.
• W2131284518 cites W2149628585 @default.

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