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• W2131288360 endingPage "e10435" @default.
• W2131288360 startingPage "e10435" @default.
• W2131288360 abstract "Insects experience a wide array of chemical pressures from plant allelochemicals and pesticides and have developed several effective counterstrategies to cope with such toxins. Among these, cytochrome P450 monooxygenases are crucial in plant-insect interactions. Flavin-dependent monooxygenases (FMOs) seem not to play a central role in xenobiotic detoxification in insects, in contrast to mammals. However, the previously identified senecionine N-oxygenase of the arctiid moth Tyria jacobaeae (Lepidoptera) indicates that FMOs have been recruited during the adaptation of this insect to plants that accumulate toxic pyrrolizidine alkaloids. Identification of related FMO-like sequences of various arctiids and other Lepidoptera and their combination with expressed sequence tag (EST) data and sequences emerging from the Bombyx mori genome project show that FMOs in Lepidoptera form a gene family with three members (FMO1 to FMO3). Phylogenetic analyses suggest that FMO3 is only distantly related to lepidopteran FMO1 and FMO2 that originated from a more recent gene duplication event. Within the FMO1 gene cluster, an additional gene duplication early in the arctiid lineage provided the basis for the evolution of the highly specific biochemical, physiological, and behavioral adaptations of these butterflies to pyrrolizidine-alkaloid-producing plants. The genes encoding pyrrolizidine-alkaloid-N-oxygenizing enzymes (PNOs) are transcribed in the fat body and the head of the larvae. An N-terminal signal peptide mediates the transport of the soluble proteins into the hemolymph where PNOs efficiently convert pro-toxic pyrrolizidine alkaloids into their non-toxic N-oxide derivatives. Heterologous expression of a PNO of the generalist arctiid Grammia geneura produced an N-oxygenizing enzyme that shows noticeably expanded substrate specificity compared with the related enzyme of the specialist Tyria jacobaeae. The data about the evolution of FMOs within lepidopteran insects and the functional characterization of a further member of this enzyme family shed light on this almost uncharacterized detoxification system in insects." @default.
• W2131288360 created "2016-06-24" @default.
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• W2131288360 date "2010-05-03" @default.
• W2131288360 modified "2023-10-01" @default.
• W2131288360 title "Flavin-Dependent Monooxygenases as a Detoxification Mechanism in Insects: New Insights from the Arctiids (Lepidoptera)" @default.
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• W2131288360 cites W1536886974 @default.
• W2131288360 cites W1538761328 @default.
• W2131288360 cites W1546639740 @default.
• W2131288360 cites W1563297777 @default.
• W2131288360 cites W1803178544 @default.
• W2131288360 cites W1873199501 @default.
• W2131288360 cites W1963526368 @default.
• W2131288360 cites W1964281508 @default.
• W2131288360 cites W1968224856 @default.
• W2131288360 cites W1970210943 @default.
• W2131288360 cites W1971470207 @default.
• W2131288360 cites W1972189799 @default.
• W2131288360 cites W1975933675 @default.
• W2131288360 cites W1988999239 @default.
• W2131288360 cites W1992602187 @default.
• W2131288360 cites W1992925265 @default.
• W2131288360 cites W1993445042 @default.
• W2131288360 cites W2004283801 @default.
• W2131288360 cites W2004428759 @default.
• W2131288360 cites W2006899772 @default.
• W2131288360 cites W2007671292 @default.
• W2131288360 cites W2010547715 @default.
• W2131288360 cites W2014623269 @default.
• W2131288360 cites W2015911443 @default.
• W2131288360 cites W2027789232 @default.
• W2131288360 cites W2027816981 @default.
• W2131288360 cites W2029436323 @default.
• W2131288360 cites W2030491699 @default.
• W2131288360 cites W2033048136 @default.
• W2131288360 cites W2036529190 @default.
• W2131288360 cites W2044854256 @default.
• W2131288360 cites W2047242099 @default.
• W2131288360 cites W2048048104 @default.
• W2131288360 cites W2055370635 @default.
• W2131288360 cites W2055749578 @default.
• W2131288360 cites W2070779276 @default.
• W2131288360 cites W2074773204 @default.
• W2131288360 cites W2084541735 @default.
• W2131288360 cites W2089869480 @default.
• W2131288360 cites W2091880550 @default.
• W2131288360 cites W2092430503 @default.
• W2131288360 cites W2095027537 @default.
• W2131288360 cites W2097382368 @default.
• W2131288360 cites W2097706568 @default.
• W2131288360 cites W2098082325 @default.
• W2131288360 cites W2100536490 @default.
• W2131288360 cites W2102526703 @default.
• W2131288360 cites W2110398444 @default.
• W2131288360 cites W2110489533 @default.
• W2131288360 cites W2113061953 @default.
• W2131288360 cites W2115155704 @default.
• W2131288360 cites W2129661019 @default.
• W2131288360 cites W2136233218 @default.
• W2131288360 cites W2137572691 @default.
• W2131288360 cites W2144590649 @default.
• W2131288360 cites W2146138967 @default.
• W2131288360 cites W2151363277 @default.
• W2131288360 cites W2152458080 @default.
• W2131288360 cites W2152770371 @default.
• W2131288360 cites W2158120166 @default.
• W2131288360 cites W2161746138 @default.
• W2131288360 cites W2167731416 @default.
• W2131288360 cites W2169957245 @default.
• W2131288360 cites W2170594190 @default.
• W2131288360 cites W2188343034 @default.
• W2131288360 cites W2417956508 @default.
• W2131288360 cites W243303449 @default.
• W2131288360 cites W2493442865 @default.
• W2131288360 cites W2598983807 @default.
• W2131288360 cites W3199943451 @default.
• W2131288360 cites W3217316274 @default.
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• W2131288360 doi "https://doi.org/10.1371/journal.pone.0010435" @default.
• W2131288360 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2862711" @default.
• W2131288360 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20454663" @default.
• W2131288360 hasPublicationYear "2010" @default.
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