FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2131324637> ?p ?o ?g. }

• W2131324637 endingPage "1403" @default.
• W2131324637 startingPage "1396" @default.
• W2131324637 abstract "Schizophrenia is a complex pathology characterized by the occurrence of a variety of symptoms classified as positive, negative and cognitive. Although the exact etiopathogenesis of this disorder has not been unraveled yet, many theories have been endorsed during the last years. Among these, the neurochemical theories have been the most suited, considering the dopaminergic and glutamatergic dysfunctions to be mainly responsible for psychotic symptoms. However, the lack of efficacy of the available drugs, namely antipsychotics, toward negative and cognitive symptoms led to hypothesize alternative approaches. In this regard, the neurodevelopmental theory of schizophrenia has emerged, proposing the association between the occurrence of environmental risk factors in early-life and the development of psychosis in late-life. In particular, exposure to early life stressing situations, such as pre- and peri-natal stress, has been suggested as a risk factor to d evelop psychopathologies in adulthood in people genetically predisposed. A crucial support in favor of this hypothesis came from neurodevelopmental animal models of schizophrenia, such as maternal malnutrition, maternal deprivation, maternal infections as well as post-weaning social isolation rearing. Moreover, data from these models, corroborated by clinical findings, indicate that oxidative and nitrosative stress play a crucial role in the etiopathogenesis of psychiatric disorders. In the present work, we reviewed the recent progress in literature regarding data available from animal models linking oxidative and nitrosative stress to psychiatric disorders in order to evaluate novel biomarkers of pathology as well as novel therapeutical targets. Keywords: Early life stress, NOX, NOS, psychiatric disorders, NMDA receptors, nitric oxide, social isolation, maternal stress." @default.
• W2131324637 created "2016-06-24" @default.
• W2131324637 creator A5019816959 @default.
• W2131324637 creator A5040083988 @default.
• W2131324637 creator A5069665643 @default.
• W2131324637 date "2015-02-15" @default.
• W2131324637 modified "2023-09-24" @default.
• W2131324637 title "Early Life and Oxidative Stress in Psychiatric Disorders: What Can we Learn From Animal Models?" @default.
• W2131324637 cites W1492951734 @default.
• W2131324637 cites W1494795538 @default.
• W2131324637 cites W1591006889 @default.
• W2131324637 cites W1593120211 @default.
• W2131324637 cites W1919985451 @default.
• W2131324637 cites W1924622891 @default.
• W2131324637 cites W1953682488 @default.
• W2131324637 cites W1961040664 @default.
• W2131324637 cites W1964523194 @default.
• W2131324637 cites W1965045465 @default.
• W2131324637 cites W1967357831 @default.
• W2131324637 cites W1967879639 @default.
• W2131324637 cites W1968564077 @default.
• W2131324637 cites W1968700646 @default.
• W2131324637 cites W1974003946 @default.
• W2131324637 cites W1974842738 @default.
• W2131324637 cites W1977328014 @default.
• W2131324637 cites W1977513618 @default.
• W2131324637 cites W1977595105 @default.
• W2131324637 cites W1977917668 @default.
• W2131324637 cites W1977970638 @default.
• W2131324637 cites W1979037328 @default.
• W2131324637 cites W1979121076 @default.
• W2131324637 cites W1981920636 @default.
• W2131324637 cites W1982085892 @default.
• W2131324637 cites W1983006348 @default.
• W2131324637 cites W1983239397 @default.
• W2131324637 cites W1985107882 @default.
• W2131324637 cites W1987555863 @default.
• W2131324637 cites W1987741893 @default.
• W2131324637 cites W1987843838 @default.
• W2131324637 cites W1987930548 @default.
• W2131324637 cites W1988848183 @default.
• W2131324637 cites W1989541862 @default.
• W2131324637 cites W1989597801 @default.
• W2131324637 cites W1992316325 @default.
• W2131324637 cites W1992888580 @default.
• W2131324637 cites W1994155561 @default.
• W2131324637 cites W1995362640 @default.
• W2131324637 cites W1995502956 @default.
• W2131324637 cites W1998927142 @default.
• W2131324637 cites W1999107915 @default.
• W2131324637 cites W1999397021 @default.
• W2131324637 cites W2001382581 @default.
• W2131324637 cites W2002370860 @default.
• W2131324637 cites W2004873214 @default.
• W2131324637 cites W2005595350 @default.
• W2131324637 cites W2007534790 @default.
• W2131324637 cites W2008639041 @default.
• W2131324637 cites W2011310240 @default.
• W2131324637 cites W2015045750 @default.
• W2131324637 cites W2015812713 @default.
• W2131324637 cites W2017750602 @default.
• W2131324637 cites W2018385636 @default.
• W2131324637 cites W2018648849 @default.
• W2131324637 cites W2020498032 @default.
• W2131324637 cites W2021461228 @default.
• W2131324637 cites W2022495097 @default.
• W2131324637 cites W2022595505 @default.
• W2131324637 cites W2023089678 @default.
• W2131324637 cites W2023594359 @default.
• W2131324637 cites W2024425201 @default.
• W2131324637 cites W2024559188 @default.
• W2131324637 cites W2025011978 @default.
• W2131324637 cites W2027868871 @default.
• W2131324637 cites W2027882318 @default.
• W2131324637 cites W2029059158 @default.
• W2131324637 cites W2031934337 @default.
• W2131324637 cites W2032982523 @default.
• W2131324637 cites W2033616412 @default.
• W2131324637 cites W2034910375 @default.
• W2131324637 cites W2035319691 @default.
• W2131324637 cites W2036056969 @default.
• W2131324637 cites W2039635263 @default.
• W2131324637 cites W2040408325 @default.
• W2131324637 cites W2040789766 @default.
• W2131324637 cites W2041055523 @default.
• W2131324637 cites W2041068600 @default.
• W2131324637 cites W2041365749 @default.
• W2131324637 cites W2041706711 @default.
• W2131324637 cites W2041812587 @default.
• W2131324637 cites W2043952421 @default.
• W2131324637 cites W2044973437 @default.
• W2131324637 cites W2045761141 @default.
• W2131324637 cites W2046896809 @default.
• W2131324637 cites W2047172896 @default.
• W2131324637 cites W2047887377 @default.
• W2131324637 cites W2048972745 @default.
• W2131324637 cites W2049436088 @default.
• W2131324637 cites W2050005460 @default.

• next