FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2131328336> ?p ?o ?g. }

• W2131328336 abstract "Abstract Background The causal mechanisms of differential disease progression in HIV-1 infected children remain poorly defined, and much of the accumulated knowledge comes from studies of subtype B infected individuals. The applicability of such findings to other subtypes, such as subtype C, remains to be substantiated. In this study, we longitudinally characterized the evolution of the Env V1–V5 region from seven subtype C HIV-1 perinatally infected children with different clinical outcomes. We investigated the possible influence of viral genotype and humoral immune response on disease progression in infants. Results Genetic analyses revealed that rapid progressors (infants that died in the first year of life) received and maintained a genetically homogeneous viral population throughout the disease course. In contrast, slow progressors (infants that remained clinically asymptomatic for up to four years) also exhibited low levels variation initially, but attained higher levels of diversity over time. Genetic assessment of variation, as indicated by dN/dS, showed that particular regions of Env undergo selective changes. Nevertheless, the magnitude and distribution of these changes did not segregate slow and rapid progressors. Longitudinal trends in Env V1–V5 length and the number of potential N-glycosylation sites varied among patients but also failed to discriminate between fast and slow progressors. Viral isolates from rapid progressors and slow progressors displayed no significant growth properties differences in vitro . The neutralizing activity in maternal and infant baseline plasma also varied in its effectiveness against the initial virus from the infants but did not differentiate rapid from slow progressors. Quantification of the neutralization susceptibility of the initial infant viral isolates to maternal baseline plasma indicated that both sensitive and resistant viruses were transmitted, irrespective of disease course. We showed that humoral immunity, whether passively acquired or developed de novo in the infected children, varied but was not predictive of disease progression. Conclusion Our data suggest that neither genetic variation in env , or initial maternal neutralizing activity, or the level of passively acquired neutralizing antibody, or the level of the de novo neutralization response appear to be linked to differences in disease progression in subtype C HIV-1 infected children." @default.
• W2131328336 created "2016-06-24" @default.
• W2131328336 creator A5005156366 @default.
• W2131328336 creator A5026961827 @default.
• W2131328336 creator A5036579975 @default.
• W2131328336 creator A5039928708 @default.
• W2131328336 creator A5051562000 @default.
• W2131328336 creator A5052560107 @default.
• W2131328336 creator A5058666321 @default.
• W2131328336 creator A5063292461 @default.
• W2131328336 creator A5074960789 @default.
• W2131328336 creator A5082157757 @default.
• W2131328336 date "2006-10-20" @default.
• W2131328336 modified "2023-10-18" @default.
• W2131328336 title "Characterization of HIV-1 subtype C envelope glycoproteins from perinatally infected children with different courses of disease" @default.
• W2131328336 cites W1481103413 @default.
• W2131328336 cites W1539316786 @default.
• W2131328336 cites W1562534199 @default.
• W2131328336 cites W1633681515 @default.
• W2131328336 cites W1723922714 @default.
• W2131328336 cites W1860192217 @default.
• W2131328336 cites W1876598876 @default.
• W2131328336 cites W1923186253 @default.
• W2131328336 cites W1953822958 @default.
• W2131328336 cites W1966421461 @default.
• W2131328336 cites W1968347927 @default.
• W2131328336 cites W1974416704 @default.
• W2131328336 cites W1974839791 @default.
• W2131328336 cites W1975994200 @default.
• W2131328336 cites W1980929359 @default.
• W2131328336 cites W1981548028 @default.
• W2131328336 cites W1997677784 @default.
• W2131328336 cites W2001800250 @default.
• W2131328336 cites W2005177157 @default.
• W2131328336 cites W2011541285 @default.
• W2131328336 cites W2012103066 @default.
• W2131328336 cites W2021644405 @default.
• W2131328336 cites W2024970873 @default.
• W2131328336 cites W2025526220 @default.
• W2131328336 cites W2026444780 @default.
• W2131328336 cites W2035290831 @default.
• W2131328336 cites W2036802319 @default.
• W2131328336 cites W2042601802 @default.
• W2131328336 cites W2048574795 @default.
• W2131328336 cites W2052229975 @default.
• W2131328336 cites W2057506112 @default.
• W2131328336 cites W2059873581 @default.
• W2131328336 cites W2064130459 @default.
• W2131328336 cites W2064557078 @default.
• W2131328336 cites W2069407559 @default.
• W2131328336 cites W2071456703 @default.
• W2131328336 cites W2074046516 @default.
• W2131328336 cites W2080404418 @default.
• W2131328336 cites W2084197987 @default.
• W2131328336 cites W2088965973 @default.
• W2131328336 cites W2094829985 @default.
• W2131328336 cites W2095497026 @default.
• W2131328336 cites W2096003181 @default.
• W2131328336 cites W2100267080 @default.
• W2131328336 cites W2100488258 @default.
• W2131328336 cites W2102234847 @default.
• W2131328336 cites W2104634067 @default.
• W2131328336 cites W2105307973 @default.
• W2131328336 cites W2106460806 @default.
• W2131328336 cites W2114596116 @default.
• W2131328336 cites W2116794821 @default.
• W2131328336 cites W2123582793 @default.
• W2131328336 cites W2127146638 @default.
• W2131328336 cites W2131639307 @default.
• W2131328336 cites W2133402813 @default.
• W2131328336 cites W2135691292 @default.
• W2131328336 cites W2137085164 @default.
• W2131328336 cites W2137966586 @default.
• W2131328336 cites W2143663670 @default.
• W2131328336 cites W2143977260 @default.
• W2131328336 cites W2144368480 @default.
• W2131328336 cites W2144539981 @default.
• W2131328336 cites W2146396346 @default.
• W2131328336 cites W2146672876 @default.
• W2131328336 cites W2147710356 @default.
• W2131328336 cites W2147915261 @default.
• W2131328336 cites W2149629952 @default.
• W2131328336 cites W2157112409 @default.
• W2131328336 cites W2157615131 @default.
• W2131328336 cites W2159277408 @default.
• W2131328336 cites W2161202915 @default.
• W2131328336 cites W2168685144 @default.
• W2131328336 cites W2171559522 @default.
• W2131328336 cites W2320433970 @default.
• W2131328336 cites W2342220526 @default.
• W2131328336 cites W4256006039 @default.
• W2131328336 doi "https://doi.org/10.1186/1742-4690-3-73" @default.
• W2131328336 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1635063" @default.
• W2131328336 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17054795" @default.
• W2131328336 hasPublicationYear "2006" @default.
• W2131328336 type Work @default.
• W2131328336 sameAs 2131328336 @default.
• W2131328336 citedByCount "50" @default.
• W2131328336 countsByYear W21313283362012 @default.
• W2131328336 countsByYear W21313283362013 @default.

• next