Matches in SemOpenAlex for { <https://semopenalex.org/work/W2131330449> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2131330449 endingPage "242" @default.
- W2131330449 startingPage "233" @default.
- W2131330449 abstract "The production of recombinant human interleukin-2 in a fluidized bed bioreactor containing porous glass carriers is described. Cultivations were carried out with different medium formulations over 80 days. Maximal cell densities and product yield could be maintained even when protein free medium was perfused, with less than 10% cell washout. Due to this effective immobilization of the cells in the reactor, continuous operation was easy to perform. Final cell densities on the order of 3.8 × 108 mL−1 intrasphere volume were reached while the interleukin-2 production rate was 0.75 mg L−1 d−1. The production rate showed a maximum of a 1.9 fold decrease compared with a homogeneous stirred bubble-free aerated system. This result was in contrast to that achieved with hybridoma cell lines, where better performance was obtained with the fluidized bed bioreactor. The situation may reflect the problems caused by the dense cell culture with adherent cells, as previously shown in a hollow-fiber bioreactor with the same cell line." @default.
- W2131330449 created "2016-06-24" @default.
- W2131330449 creator A5045616811 @default.
- W2131330449 creator A5065065109 @default.
- W2131330449 date "1992-01-20" @default.
- W2131330449 modified "2023-10-10" @default.
- W2131330449 title "Evaluation of production of recombinant human interleukin-2 in fluidized bed bioreactor" @default.
- W2131330449 cites W102798308 @default.
- W2131330449 cites W1506157243 @default.
- W2131330449 cites W1573196340 @default.
- W2131330449 cites W1579051060 @default.
- W2131330449 cites W1634893639 @default.
- W2131330449 cites W1970342642 @default.
- W2131330449 cites W2005920368 @default.
- W2131330449 cites W2017533728 @default.
- W2131330449 cites W2025322681 @default.
- W2131330449 cites W203387550 @default.
- W2131330449 cites W2038323008 @default.
- W2131330449 cites W2046428019 @default.
- W2131330449 cites W2053072959 @default.
- W2131330449 cites W2053743092 @default.
- W2131330449 cites W2082010047 @default.
- W2131330449 cites W2087869597 @default.
- W2131330449 cites W2094453144 @default.
- W2131330449 cites W2103538923 @default.
- W2131330449 cites W2484083775 @default.
- W2131330449 cites W4293247451 @default.
- W2131330449 cites W53865592 @default.
- W2131330449 doi "https://doi.org/10.1002/bit.260390216" @default.
- W2131330449 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18600936" @default.
- W2131330449 hasPublicationYear "1992" @default.
- W2131330449 type Work @default.
- W2131330449 sameAs 2131330449 @default.
- W2131330449 citedByCount "22" @default.
- W2131330449 countsByYear W21313304492013 @default.
- W2131330449 countsByYear W21313304492017 @default.
- W2131330449 crossrefType "journal-article" @default.
- W2131330449 hasAuthorship W2131330449A5045616811 @default.
- W2131330449 hasAuthorship W2131330449A5065065109 @default.
- W2131330449 hasConcept C104317684 @default.
- W2131330449 hasConcept C121332964 @default.
- W2131330449 hasConcept C134121241 @default.
- W2131330449 hasConcept C153294291 @default.
- W2131330449 hasConcept C159985019 @default.
- W2131330449 hasConcept C168170006 @default.
- W2131330449 hasConcept C178790620 @default.
- W2131330449 hasConcept C185592680 @default.
- W2131330449 hasConcept C192562407 @default.
- W2131330449 hasConcept C20556612 @default.
- W2131330449 hasConcept C2084832 @default.
- W2131330449 hasConcept C40767141 @default.
- W2131330449 hasConcept C43617362 @default.
- W2131330449 hasConcept C55493867 @default.
- W2131330449 hasConcept C71839028 @default.
- W2131330449 hasConcept C86922832 @default.
- W2131330449 hasConcept C97355855 @default.
- W2131330449 hasConceptScore W2131330449C104317684 @default.
- W2131330449 hasConceptScore W2131330449C121332964 @default.
- W2131330449 hasConceptScore W2131330449C134121241 @default.
- W2131330449 hasConceptScore W2131330449C153294291 @default.
- W2131330449 hasConceptScore W2131330449C159985019 @default.
- W2131330449 hasConceptScore W2131330449C168170006 @default.
- W2131330449 hasConceptScore W2131330449C178790620 @default.
- W2131330449 hasConceptScore W2131330449C185592680 @default.
- W2131330449 hasConceptScore W2131330449C192562407 @default.
- W2131330449 hasConceptScore W2131330449C20556612 @default.
- W2131330449 hasConceptScore W2131330449C2084832 @default.
- W2131330449 hasConceptScore W2131330449C40767141 @default.
- W2131330449 hasConceptScore W2131330449C43617362 @default.
- W2131330449 hasConceptScore W2131330449C55493867 @default.
- W2131330449 hasConceptScore W2131330449C71839028 @default.
- W2131330449 hasConceptScore W2131330449C86922832 @default.
- W2131330449 hasConceptScore W2131330449C97355855 @default.
- W2131330449 hasIssue "2" @default.
- W2131330449 hasLocation W21313304491 @default.
- W2131330449 hasLocation W21313304492 @default.
- W2131330449 hasOpenAccess W2131330449 @default.
- W2131330449 hasPrimaryLocation W21313304491 @default.
- W2131330449 hasRelatedWork W1998161780 @default.
- W2131330449 hasRelatedWork W2049977812 @default.
- W2131330449 hasRelatedWork W2149958094 @default.
- W2131330449 hasRelatedWork W2353476936 @default.
- W2131330449 hasRelatedWork W2363207498 @default.
- W2131330449 hasRelatedWork W2374417185 @default.
- W2131330449 hasRelatedWork W2520671456 @default.
- W2131330449 hasRelatedWork W2902100189 @default.
- W2131330449 hasRelatedWork W4245769087 @default.
- W2131330449 hasRelatedWork W888679125 @default.
- W2131330449 hasVolume "39" @default.
- W2131330449 isParatext "false" @default.
- W2131330449 isRetracted "false" @default.
- W2131330449 magId "2131330449" @default.
- W2131330449 workType "article" @default.