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• W2131363312 abstract "Human skin equivalents (HSEs) can be considered a valuable tool to study aspects of human skin, including the skin barrier, or to perform chemical or toxicological screenings. HSEs are three-dimensional skin models that are usually established using primary keratinocytes and closely mimic human skin. The use of primary keratinocytes has several drawbacks, including a limited in vitro life span and large donor-donor variation. This makes them less favorable for in vitro toxicity screenings. Usage of an established keratinocyte cell line circumvents these drawbacks and enables the generation of easy-to-generate and reproducible HSEs, which can be used for pharmacological and/or toxicological screenings. For such screenings, a proper barrier function is required. In this study, we investigated the barrier properties of HSEs established with the keratinocyte cell line N/TERT (N-HSEs). N-HSEs showed comparable tissue morphology and expression of several epidermal proteins compared with HSEs established with primary keratinocytes. Our results clearly demonstrate that N-HSEs not only contain several stratum corneum (SC) barrier properties similar to HSEs, including the presence of the long periodicity phase and a comparable SC permeability, but also show some differences in lipid composition. Nonetheless, the similarities in barrier properties makes N/TERT cells a promising alternative for primary keratinocytes to generate HSEs." @default.
• W2131363312 created "2016-06-24" @default.
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• W2131363312 date "2014-11-01" @default.
• W2131363312 modified "2023-10-16" @default.
• W2131363312 title "Barrier Properties of an N/TERT-Based Human Skin Equivalent" @default.
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• W2131363312 doi "https://doi.org/10.1089/ten.tea.2014.0011" @default.
• W2131363312 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4229711" @default.
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• W2131363312 hasPublicationYear "2014" @default.
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