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- W2131365593 abstract "SUMMARY When T6/+ female mice were mated to non-translocation-bearing males, the relative viability of the embryos at 13·5–14·5 days gestation was about 39%. About 36% of the oocytes ovulated by T6/+ females were aneuploid, as a result of non-disjunction at meiosis, the majority having either 19 or 21 chromosomes. However, aneuploidy only accounts for a proportion of the embryonic loss in T6/+ × +/+ matings, as many of the embryos with 41 chromosomes survive postnatally. The present findings indicate that approximately 50% of the oocytes ovulated with the normal haploid number of chromosomes ( n = 20) were genetically unbalanced as a result of adjacent segregation, and that a high proportion of the resultant embryos die in the early postimplantation period. In the present study non-translocation-bearing mice which were genotypically similar to the T6/+ females acted as controls." @default.
- W2131365593 created "2016-06-24" @default.
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- W2131365593 date "1976-02-01" @default.
- W2131365593 modified "2023-10-18" @default.
- W2131365593 title "The incidence of chromosomally unbalanced gametes in T(14; 15)6 Ca heterozygote mice" @default.
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- W2131365593 doi "https://doi.org/10.1017/s0016672300016256" @default.
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