FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2131372305> ?p ?o ?g. }

• W2131372305 endingPage "690" @default.
• W2131372305 startingPage "672" @default.
• W2131372305 abstract "Abstract The strong relationship between over‐nutrition, central obesity, insulin resistance/metabolic syndrome and non‐alcoholic fatty liver disease (NAFLD) suggest pathogenic interactions, but key questions remain. NAFLD starts with over‐nutrition, imbalance between energy input and output for which the roles of genetic predisposition and environmental factors (diet, physical activity) are being redefined. Regulation of energy balance operates at both central nervous system and peripheral sites, including adipose and liver. For example, the endocannabinoid system could potentially be modulated to provide effective pharmacotherapy of NAFLD. The more profound the metabolic abnormalities complicating over‐nutrition (glucose intolerance, hypoadiponectinemia, metabolic syndrome), the more likely is NAFLD to take on its progressive guise of non‐alcoholic steatohepatitis (NASH). Interactions between steatosis and insulin resistance, visceral adipose expansion and subcutaneous adipose failure (with insulin resistance, inflammation and hypoadiponectinemia) trigger amplifying mechanisms for liver disease. Thus, transition from simple steatosis to NASH could be explained by unmitigated hepatic lipid partitioning with failure of local adaptive mechanisms leading to lipotoxicity. In part one of this review, we discuss newer concepts of appetite and metabolic regulation, bodily lipid distribution, hepatic lipid turnover, insulin resistance and adipose failure affecting adiponectin secretion. We review evidence that NASH only occurs when over‐nutrition is complicated by insulin resistance and a highly disordered metabolic milieu, the same ‘metabolic movers’ that promote type 2 diabetes and atheromatous cardiovascular disease. The net effect is accumulation of lipid molecules in the liver. Which lipids and how they cause injury, inflammation and fibrosis will be discussed in part two." @default.
• W2131372305 created "2016-06-24" @default.
• W2131372305 creator A5017524854 @default.
• W2131372305 creator A5074255400 @default.
• W2131372305 creator A5076090034 @default.
• W2131372305 creator A5091899489 @default.
• W2131372305 date "2010-03-25" @default.
• W2131372305 modified "2023-10-16" @default.
• W2131372305 title "A fresh look at NASH pathogenesis. Part 1: The metabolic movers" @default.
• W2131372305 cites W1499189927 @default.
• W2131372305 cites W1534360145 @default.
• W2131372305 cites W1558228229 @default.
• W2131372305 cites W1567156395 @default.
• W2131372305 cites W1569693056 @default.
• W2131372305 cites W1574804156 @default.
• W2131372305 cites W1589397268 @default.
• W2131372305 cites W1639930240 @default.
• W2131372305 cites W1963533730 @default.
• W2131372305 cites W1964396402 @default.
• W2131372305 cites W1966103999 @default.
• W2131372305 cites W1970653898 @default.
• W2131372305 cites W1972003125 @default.
• W2131372305 cites W1975388439 @default.
• W2131372305 cites W1977924547 @default.
• W2131372305 cites W1978496847 @default.
• W2131372305 cites W1978587175 @default.
• W2131372305 cites W1979165845 @default.
• W2131372305 cites W1981219457 @default.
• W2131372305 cites W1981576376 @default.
• W2131372305 cites W1982578021 @default.
• W2131372305 cites W1983082230 @default.
• W2131372305 cites W1984821297 @default.
• W2131372305 cites W1985233700 @default.
• W2131372305 cites W1985478480 @default.
• W2131372305 cites W1985592156 @default.
• W2131372305 cites W1989912256 @default.
• W2131372305 cites W1991079474 @default.
• W2131372305 cites W1992290928 @default.
• W2131372305 cites W1993266217 @default.
• W2131372305 cites W1993331859 @default.
• W2131372305 cites W1994975332 @default.
• W2131372305 cites W1995775946 @default.
• W2131372305 cites W1996775250 @default.
• W2131372305 cites W1997757017 @default.
• W2131372305 cites W2001660140 @default.
• W2131372305 cites W2001892130 @default.
• W2131372305 cites W2002848248 @default.
• W2131372305 cites W2004461660 @default.
• W2131372305 cites W2007582317 @default.
• W2131372305 cites W2008162733 @default.
• W2131372305 cites W2009544238 @default.
• W2131372305 cites W2010876773 @default.
• W2131372305 cites W2011447726 @default.
• W2131372305 cites W2012441815 @default.
• W2131372305 cites W2013098217 @default.
• W2131372305 cites W2013654496 @default.
• W2131372305 cites W2016526435 @default.
• W2131372305 cites W2017511982 @default.
• W2131372305 cites W2019973807 @default.
• W2131372305 cites W2020729319 @default.
• W2131372305 cites W2021628230 @default.
• W2131372305 cites W2025163736 @default.
• W2131372305 cites W2025683866 @default.
• W2131372305 cites W2025843189 @default.
• W2131372305 cites W2028536174 @default.
• W2131372305 cites W2028563320 @default.
• W2131372305 cites W2028962874 @default.
• W2131372305 cites W2030744989 @default.
• W2131372305 cites W2033740553 @default.
• W2131372305 cites W2035816889 @default.
• W2131372305 cites W2036735196 @default.
• W2131372305 cites W2038060844 @default.
• W2131372305 cites W2038194700 @default.
• W2131372305 cites W2040109162 @default.
• W2131372305 cites W2040834848 @default.
• W2131372305 cites W2042706232 @default.
• W2131372305 cites W2045182106 @default.
• W2131372305 cites W2045672949 @default.
• W2131372305 cites W2046338866 @default.
• W2131372305 cites W2047257800 @default.
• W2131372305 cites W2048104183 @default.
• W2131372305 cites W2051051060 @default.
• W2131372305 cites W2052173704 @default.
• W2131372305 cites W2053426841 @default.
• W2131372305 cites W2054706730 @default.
• W2131372305 cites W2055355179 @default.
• W2131372305 cites W2055604801 @default.
• W2131372305 cites W2059063316 @default.
• W2131372305 cites W2067324334 @default.
• W2131372305 cites W2067740038 @default.
• W2131372305 cites W2068516092 @default.
• W2131372305 cites W2068638478 @default.
• W2131372305 cites W2069578030 @default.
• W2131372305 cites W2069764880 @default.
• W2131372305 cites W2070680921 @default.
• W2131372305 cites W2071172690 @default.
• W2131372305 cites W2071867050 @default.
• W2131372305 cites W2073037204 @default.

• next