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- W2131387907 endingPage "6418" @default.
- W2131387907 startingPage "6407" @default.
- W2131387907 abstract "There is a growing consensus that the various forms of cell death (necrosis, apoptosis and autophagy) are not separated by strict boundaries, but rather share molecular effectors and signaling routes. Among the latter, a clear role is played by calcium (Ca(2+)), the ubiquitous second messenger involved in the control of a broad variety of physiological events. Fine tuning of intracellular Ca(2+) homeostasis by anti- and proapoptotic proteins shapes the Ca(2+) signal to which mitochondria and other cellular effectors are exposed, and hence the efficiency of various cell death inducers. Here, we will review: (i) the evidence linking calcium homeostasis to the regulation of apoptotic, and more recently autophagic cell death, (ii) the discussion of mitochondria as a critical, although not unique checkpoint and (iii) the molecular and functional elucidation of ER/mitochondria contacts, corresponding to the mitochondria-associated membrane (MAM) subfraction and proposed to be a specialized signaling microdomain." @default.
- W2131387907 created "2016-06-24" @default.
- W2131387907 creator A5012389506 @default.
- W2131387907 creator A5027748782 @default.
- W2131387907 creator A5050406033 @default.
- W2131387907 creator A5070894673 @default.
- W2131387907 creator A5086468991 @default.
- W2131387907 date "2008-10-27" @default.
- W2131387907 modified "2023-10-17" @default.
- W2131387907 title "Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis" @default.
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