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- W2131454507 startingPage "1416" @default.
- W2131454507 abstract "Crohn's disease (CD) is a chronic inflammatory bowel disease. Research has identified genetic predisposition and environmental factors as key elements in the development of the disease. However, the precise mechanism that initiates immune activation remains undefined. One pathway for luminal antigenic molecules to enter the sterile lamina propria and activate an immune response is via transcytosis. Transcytosis, although tightly regulated by the cell, has the potential for transepithelial transport of bacteria and highly antigenic luminal molecules whose uncontrolled translocation into the lamina propria can be the source of immune activation. Viewed as a whole, the evidence suggests that unregulated intestinal epithelial transcytosis is involved in the inappropriate presentation of immunogenic luminal macromolecules to the intestinal lamina propria. Thus fulfilling the role of an early pre-morbid mechanism that can result in antigenic overload of the lamina propria and initiate an immune response culminating in chronic inflammation characteristic of this disease. It is the aim of this paper to present evidence implicating enterocyte transcytosis in the early etio-pathogenesis of CD." @default.
- W2131454507 created "2016-06-24" @default.
- W2131454507 creator A5039897246 @default.
- W2131454507 date "2011-01-01" @default.
- W2131454507 modified "2023-10-17" @default.
- W2131454507 title "Crohn’s disease: Evidence for involvement of unregulated transcytosis in disease etio-pathogenesis" @default.
- W2131454507 cites W119681657 @default.
- W2131454507 cites W1319875 @default.
- W2131454507 cites W1519165829 @default.
- W2131454507 cites W1528123693 @default.
- W2131454507 cites W1546749202 @default.
- W2131454507 cites W1580337909 @default.
- W2131454507 cites W1596248923 @default.
- W2131454507 cites W1619845989 @default.
- W2131454507 cites W1698452649 @default.
- W2131454507 cites W1782218263 @default.
- W2131454507 cites W1827831627 @default.
- W2131454507 cites W1847449663 @default.
- W2131454507 cites W186071900 @default.
- W2131454507 cites W1968246688 @default.
- W2131454507 cites W1969354506 @default.
- W2131454507 cites W1970016354 @default.
- W2131454507 cites W1970708173 @default.
- W2131454507 cites W1971436269 @default.
- W2131454507 cites W1971647996 @default.
- W2131454507 cites W1973190959 @default.
- W2131454507 cites W1973685023 @default.
- W2131454507 cites W1973829957 @default.
- W2131454507 cites W1980340961 @default.
- W2131454507 cites W1981194531 @default.
- W2131454507 cites W1982649164 @default.
- W2131454507 cites W1985660854 @default.
- W2131454507 cites W1986807124 @default.
- W2131454507 cites W1991212258 @default.
- W2131454507 cites W1992940409 @default.
- W2131454507 cites W1996008964 @default.
- W2131454507 cites W1997702183 @default.
- W2131454507 cites W1999507242 @default.
- W2131454507 cites W200172139 @default.
- W2131454507 cites W2002191377 @default.
- W2131454507 cites W2004581543 @default.
- W2131454507 cites W2006717114 @default.
- W2131454507 cites W2009446106 @default.
- W2131454507 cites W2011282882 @default.
- W2131454507 cites W2015377669 @default.
- W2131454507 cites W2020994992 @default.
- W2131454507 cites W2021076983 @default.
- W2131454507 cites W2022975557 @default.
- W2131454507 cites W2026044458 @default.
- W2131454507 cites W2027408013 @default.
- W2131454507 cites W2031791761 @default.
- W2131454507 cites W2037778651 @default.
- W2131454507 cites W2039618284 @default.
- W2131454507 cites W2039927136 @default.
- W2131454507 cites W2040682568 @default.
- W2131454507 cites W2042815880 @default.
- W2131454507 cites W2045138690 @default.
- W2131454507 cites W2046133662 @default.
- W2131454507 cites W2050431295 @default.
- W2131454507 cites W2052406388 @default.
- W2131454507 cites W2061791452 @default.
- W2131454507 cites W2065644803 @default.
- W2131454507 cites W2070608456 @default.
- W2131454507 cites W2074782193 @default.
- W2131454507 cites W2075425643 @default.
- W2131454507 cites W2075936096 @default.
- W2131454507 cites W2076121001 @default.
- W2131454507 cites W2077198680 @default.
- W2131454507 cites W2077839824 @default.
- W2131454507 cites W2078905435 @default.
- W2131454507 cites W2080496225 @default.
- W2131454507 cites W2081135977 @default.
- W2131454507 cites W2084621494 @default.
- W2131454507 cites W2087421040 @default.
- W2131454507 cites W2088826436 @default.
- W2131454507 cites W2095403986 @default.
- W2131454507 cites W2098544544 @default.
- W2131454507 cites W2099444176 @default.
- W2131454507 cites W2104216656 @default.
- W2131454507 cites W2107986169 @default.
- W2131454507 cites W2111032891 @default.
- W2131454507 cites W2113441069 @default.
- W2131454507 cites W2113590483 @default.
- W2131454507 cites W21158304 @default.
- W2131454507 cites W2115894894 @default.
- W2131454507 cites W2118071672 @default.
- W2131454507 cites W2119066946 @default.
- W2131454507 cites W2120424719 @default.
- W2131454507 cites W2120892326 @default.
- W2131454507 cites W2123170641 @default.
- W2131454507 cites W2125776483 @default.
- W2131454507 cites W2126339695 @default.
- W2131454507 cites W2128343842 @default.
- W2131454507 cites W2130107202 @default.
- W2131454507 cites W2132030026 @default.
- W2131454507 cites W2136180330 @default.
- W2131454507 cites W2138642538 @default.
- W2131454507 cites W2140981202 @default.