Matches in SemOpenAlex for { <https://semopenalex.org/work/W2131465407> ?p ?o ?g. }
- W2131465407 endingPage "3060" @default.
- W2131465407 startingPage "3051" @default.
- W2131465407 abstract "Glucocorticoid (GC) excess adversely affects skin integrity, inducing thinning and impaired wound healing. Aged skin, particularly that which has been photo-exposed, shares a similar phenotype. Previously, we demonstrated age-induced expression of the GC-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) in cultured human dermal fibroblasts (HDFs). Here, we determined 11β-HSD1 levels in human skin biopsies from young and older volunteers and examined the aged 11β-HSD1 KO mouse skin phenotype. 11β-HSD1 activity was elevated in aged human and mouse skin and in PE compared with donor-matched photo-protected human biopsies. Age-induced dermal atrophy with deranged collagen structural organization was prevented in 11β-HSD1 KO mice, which also exhibited increased collagen density. We found that treatment of HDFs with physiological concentrations of cortisol inhibited rate-limiting steps in collagen biosynthesis and processing. Furthermore, topical 11β-HSD1 inhibitor treatment accelerated healing of full-thickness mouse dorsal wounds, with improved healing also observed in aged 11β-HSD1 KO mice. These findings suggest that elevated 11β-HSD1 activity in aging skin leads to increased local GC generation, which may account for adverse changes occurring in the elderly, and 11β-HSD1 inhibitors may be useful in the treatment of age-associated impairments in dermal integrity and wound healing." @default.
- W2131465407 created "2016-06-24" @default.
- W2131465407 creator A5000775853 @default.
- W2131465407 creator A5019968381 @default.
- W2131465407 creator A5024472400 @default.
- W2131465407 creator A5033884270 @default.
- W2131465407 creator A5034358714 @default.
- W2131465407 creator A5039317852 @default.
- W2131465407 creator A5042047609 @default.
- W2131465407 creator A5050877182 @default.
- W2131465407 creator A5057424817 @default.
- W2131465407 creator A5058908918 @default.
- W2131465407 creator A5071032635 @default.
- W2131465407 creator A5086196068 @default.
- W2131465407 creator A5090743194 @default.
- W2131465407 date "2013-06-03" @default.
- W2131465407 modified "2023-10-18" @default.
- W2131465407 title "11β-Hydroxysteroid dehydrogenase blockade prevents age-induced skin structure and function defects" @default.
- W2131465407 cites W1631191622 @default.
- W2131465407 cites W1921977789 @default.
- W2131465407 cites W1958721249 @default.
- W2131465407 cites W1965576057 @default.
- W2131465407 cites W1970523071 @default.
- W2131465407 cites W1970599884 @default.
- W2131465407 cites W1975314402 @default.
- W2131465407 cites W1977168455 @default.
- W2131465407 cites W1978162436 @default.
- W2131465407 cites W1978660595 @default.
- W2131465407 cites W1980724699 @default.
- W2131465407 cites W1991279492 @default.
- W2131465407 cites W1994387286 @default.
- W2131465407 cites W2000655587 @default.
- W2131465407 cites W2003953254 @default.
- W2131465407 cites W2007350878 @default.
- W2131465407 cites W2007530859 @default.
- W2131465407 cites W2012256930 @default.
- W2131465407 cites W2020615019 @default.
- W2131465407 cites W2022227132 @default.
- W2131465407 cites W2022269012 @default.
- W2131465407 cites W2023754807 @default.
- W2131465407 cites W2027647433 @default.
- W2131465407 cites W2035498695 @default.
- W2131465407 cites W2036507046 @default.
- W2131465407 cites W2038254867 @default.
- W2131465407 cites W2044342181 @default.
- W2131465407 cites W2047623048 @default.
- W2131465407 cites W2049620937 @default.
- W2131465407 cites W2049954179 @default.
- W2131465407 cites W2050146149 @default.
- W2131465407 cites W2050913250 @default.
- W2131465407 cites W2053957709 @default.
- W2131465407 cites W2072310852 @default.
- W2131465407 cites W2077292033 @default.
- W2131465407 cites W2082747116 @default.
- W2131465407 cites W2086580814 @default.
- W2131465407 cites W2089978431 @default.
- W2131465407 cites W2090913089 @default.
- W2131465407 cites W2097376951 @default.
- W2131465407 cites W2102953653 @default.
- W2131465407 cites W2108206551 @default.
- W2131465407 cites W2110076915 @default.
- W2131465407 cites W2117547532 @default.
- W2131465407 cites W2126654333 @default.
- W2131465407 cites W2144274203 @default.
- W2131465407 cites W2147016321 @default.
- W2131465407 cites W2151080115 @default.
- W2131465407 cites W2154254227 @default.
- W2131465407 cites W2170563792 @default.
- W2131465407 cites W2965635017 @default.
- W2131465407 cites W4211186562 @default.
- W2131465407 cites W4229991699 @default.
- W2131465407 cites W4256633993 @default.
- W2131465407 doi "https://doi.org/10.1172/jci64162" @default.
- W2131465407 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3696573" @default.
- W2131465407 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23722901" @default.
- W2131465407 hasPublicationYear "2013" @default.
- W2131465407 type Work @default.
- W2131465407 sameAs 2131465407 @default.
- W2131465407 citedByCount "109" @default.
- W2131465407 countsByYear W21314654072013 @default.
- W2131465407 countsByYear W21314654072014 @default.
- W2131465407 countsByYear W21314654072015 @default.
- W2131465407 countsByYear W21314654072016 @default.
- W2131465407 countsByYear W21314654072017 @default.
- W2131465407 countsByYear W21314654072018 @default.
- W2131465407 countsByYear W21314654072019 @default.
- W2131465407 countsByYear W21314654072020 @default.
- W2131465407 countsByYear W21314654072021 @default.
- W2131465407 countsByYear W21314654072022 @default.
- W2131465407 countsByYear W21314654072023 @default.
- W2131465407 crossrefType "journal-article" @default.
- W2131465407 hasAuthorship W2131465407A5000775853 @default.
- W2131465407 hasAuthorship W2131465407A5019968381 @default.
- W2131465407 hasAuthorship W2131465407A5024472400 @default.
- W2131465407 hasAuthorship W2131465407A5033884270 @default.
- W2131465407 hasAuthorship W2131465407A5034358714 @default.
- W2131465407 hasAuthorship W2131465407A5039317852 @default.
- W2131465407 hasAuthorship W2131465407A5042047609 @default.