Matches in SemOpenAlex for { <https://semopenalex.org/work/W2131468364> ?p ?o ?g. }
- W2131468364 endingPage "109" @default.
- W2131468364 startingPage "90" @default.
- W2131468364 abstract "Abstract Utilization of proton transfer in catalysis, which is well known in the mechanisms of protein enzymes, has been described only relatively recently for RNA enzymes. In this article, we present a current understanding of proton transfer by nucleic acids. Rate enhancement and specificity conferred by general acid–base catalysis are discussed. We also present possibilities for electrostatic catalysis from general acids and bases as well as cationic base pairs. The microenvironments of a large RNA provide the possibility of histidine‐like p K a s for proton transfer, as well as lysine‐ and arginine‐like p K a s for electrostatic catalysis. Discussion on proton transfer focuses on the hepatitis delta virus (HDV) and hairpin ribozymes, with select examples drawn from the protein literature. Discussion on electrostatic catalysis also draws on these two ribozymes, and a postulate for electrostatic catalysis by a cationic base pair in the mechanism of peptidyl transfer in the ribosome is presented. We also provide a perspective on possibilities for phosphoryl transfer mechanisms involving phosphorane intermediates and unusual tautomeric forms of the bases. Lastly, a distinction is made between ground state and “transition state” p K a s. We favor a model in which changes in pH lead to changes in the distribution of reactive and nonreactive ionizations of the ribozyme molecules in the ground state, and therefore suggest that “p K a changes in the transition state” do not provide an acceptable explanation for observed pH‐rate profiles. © 2003 Wiley Periodicals, Inc. Biopolymers 73: 90–109, 2004" @default.
- W2131468364 created "2016-06-24" @default.
- W2131468364 creator A5011482890 @default.
- W2131468364 creator A5053201698 @default.
- W2131468364 creator A5071514431 @default.
- W2131468364 creator A5073635082 @default.
- W2131468364 date "2003-11-11" @default.
- W2131468364 modified "2023-10-17" @default.
- W2131468364 title "Catalytic roles for proton transfer and protonation in ribozymes" @default.
- W2131468364 cites W1498399113 @default.
- W2131468364 cites W1509719644 @default.
- W2131468364 cites W1575818733 @default.
- W2131468364 cites W162254186 @default.
- W2131468364 cites W1642023497 @default.
- W2131468364 cites W1876847843 @default.
- W2131468364 cites W1881326155 @default.
- W2131468364 cites W1963688013 @default.
- W2131468364 cites W1964261732 @default.
- W2131468364 cites W1964379701 @default.
- W2131468364 cites W1969591990 @default.
- W2131468364 cites W1973775164 @default.
- W2131468364 cites W1974000520 @default.
- W2131468364 cites W1975496808 @default.
- W2131468364 cites W1976137961 @default.
- W2131468364 cites W1977192121 @default.
- W2131468364 cites W1978737991 @default.
- W2131468364 cites W1979395376 @default.
- W2131468364 cites W1980149636 @default.
- W2131468364 cites W1980410097 @default.
- W2131468364 cites W1982856746 @default.
- W2131468364 cites W1983534198 @default.
- W2131468364 cites W1983948144 @default.
- W2131468364 cites W1984181406 @default.
- W2131468364 cites W1984303266 @default.
- W2131468364 cites W1984545820 @default.
- W2131468364 cites W1985012591 @default.
- W2131468364 cites W1985271682 @default.
- W2131468364 cites W1985368446 @default.
- W2131468364 cites W1986107627 @default.
- W2131468364 cites W1988311110 @default.
- W2131468364 cites W1993091782 @default.
- W2131468364 cites W1994064653 @default.
- W2131468364 cites W1994999389 @default.
- W2131468364 cites W1996566831 @default.
- W2131468364 cites W1996873419 @default.
- W2131468364 cites W1999362400 @default.
- W2131468364 cites W2001266427 @default.
- W2131468364 cites W2002836712 @default.
- W2131468364 cites W2003906424 @default.
- W2131468364 cites W2004303971 @default.
- W2131468364 cites W2006521039 @default.
- W2131468364 cites W2007186039 @default.
- W2131468364 cites W2009120757 @default.
- W2131468364 cites W2009818318 @default.
- W2131468364 cites W2010120270 @default.
- W2131468364 cites W2014043205 @default.
- W2131468364 cites W2015360159 @default.
- W2131468364 cites W2017766716 @default.
- W2131468364 cites W2020263757 @default.
- W2131468364 cites W2023219682 @default.
- W2131468364 cites W2023580233 @default.
- W2131468364 cites W2027982808 @default.
- W2131468364 cites W2029080189 @default.
- W2131468364 cites W2029998151 @default.
- W2131468364 cites W2039951296 @default.
- W2131468364 cites W2042806005 @default.
- W2131468364 cites W2043951259 @default.
- W2131468364 cites W2043958524 @default.
- W2131468364 cites W2045894605 @default.
- W2131468364 cites W2049289210 @default.
- W2131468364 cites W2050357762 @default.
- W2131468364 cites W2050645634 @default.
- W2131468364 cites W2050956602 @default.
- W2131468364 cites W2051476053 @default.
- W2131468364 cites W2051713039 @default.
- W2131468364 cites W2052113013 @default.
- W2131468364 cites W2053471524 @default.
- W2131468364 cites W2053979579 @default.
- W2131468364 cites W2054047352 @default.
- W2131468364 cites W2055162070 @default.
- W2131468364 cites W2055886104 @default.
- W2131468364 cites W2056213135 @default.
- W2131468364 cites W2057733356 @default.
- W2131468364 cites W2057742112 @default.
- W2131468364 cites W2059352893 @default.
- W2131468364 cites W2061923011 @default.
- W2131468364 cites W2064202848 @default.
- W2131468364 cites W2065463519 @default.
- W2131468364 cites W2066156276 @default.
- W2131468364 cites W2069013989 @default.
- W2131468364 cites W2069348762 @default.
- W2131468364 cites W2070577539 @default.
- W2131468364 cites W2071569025 @default.
- W2131468364 cites W2072660673 @default.
- W2131468364 cites W2073229412 @default.
- W2131468364 cites W2073459948 @default.
- W2131468364 cites W2076274162 @default.
- W2131468364 cites W2078248271 @default.