Matches in SemOpenAlex for { <https://semopenalex.org/work/W2131469090> ?p ?o ?g. }
- W2131469090 endingPage "606" @default.
- W2131469090 startingPage "593" @default.
- W2131469090 abstract "Background: The active form of vitamin D3, 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3), plays an important role in calcium homeostasis, cell differentiation, cell proliferation and immunity. A more complete understanding of the several physiological and pharmacological properties of 1,25(OH)2D3 indicates that the vitamin D receptor (VDR) is a promising drug target in the treatment of cancers, autoimmune diseases, infections and cardiovascular disease as well as bone and mineral disorders. The calcemic effect of 1,25(OH)2D3 and its derivatives has limited their clinical application. As a result, the development of non-calcemic VDR ligands is required to realize the potential of VDR-targeting therapy. Objective: In this review, we discuss the in vitro and in vivo pharmacological actions, including VDR interaction, regulation of cofactor recruitment, pharmacokinetics and cell type or tissue-selective action of VDR ligands with less-calcemic activity. Conclusion: Pharmacokinetic parameters and selective tissue accumulation are related to the therapeutic benefit of non-hypercalcemic vitamin D derivatives. Induction of distinct VDR conformations and cofactor recruitment may be associated with selective actions of non-secosteroidal VDR ligands. Derivatives of lithocholic acid, a newly identified endogenous VDR ligand, are less-calcemic VDR ligands." @default.
- W2131469090 created "2016-06-24" @default.
- W2131469090 creator A5040084597 @default.
- W2131469090 creator A5047196134 @default.
- W2131469090 date "2009-04-08" @default.
- W2131469090 modified "2023-10-02" @default.
- W2131469090 title "Therapeutic applications for novel non-hypercalcemic vitamin D receptor ligands" @default.
- W2131469090 cites W1493588537 @default.
- W2131469090 cites W1748227957 @default.
- W2131469090 cites W1967542941 @default.
- W2131469090 cites W1968020259 @default.
- W2131469090 cites W1971262242 @default.
- W2131469090 cites W1973957773 @default.
- W2131469090 cites W1974480729 @default.
- W2131469090 cites W1983887650 @default.
- W2131469090 cites W1984345984 @default.
- W2131469090 cites W1997341767 @default.
- W2131469090 cites W1997617171 @default.
- W2131469090 cites W2002875264 @default.
- W2131469090 cites W2003225482 @default.
- W2131469090 cites W2009870053 @default.
- W2131469090 cites W2012898558 @default.
- W2131469090 cites W2018584724 @default.
- W2131469090 cites W2021206718 @default.
- W2131469090 cites W2022808915 @default.
- W2131469090 cites W2023233581 @default.
- W2131469090 cites W2023314029 @default.
- W2131469090 cites W2025741278 @default.
- W2131469090 cites W2027946868 @default.
- W2131469090 cites W2033745593 @default.
- W2131469090 cites W2035702943 @default.
- W2131469090 cites W2038376310 @default.
- W2131469090 cites W2042469150 @default.
- W2131469090 cites W2043477138 @default.
- W2131469090 cites W2044099516 @default.
- W2131469090 cites W2046284568 @default.
- W2131469090 cites W2046318425 @default.
- W2131469090 cites W2046425824 @default.
- W2131469090 cites W2048162018 @default.
- W2131469090 cites W2053516868 @default.
- W2131469090 cites W2054197171 @default.
- W2131469090 cites W2056116219 @default.
- W2131469090 cites W2057812489 @default.
- W2131469090 cites W2060369655 @default.
- W2131469090 cites W2069601660 @default.
- W2131469090 cites W2073870011 @default.
- W2131469090 cites W2076172803 @default.
- W2131469090 cites W2077427100 @default.
- W2131469090 cites W2088676519 @default.
- W2131469090 cites W2088847197 @default.
- W2131469090 cites W2089721197 @default.
- W2131469090 cites W2092636887 @default.
- W2131469090 cites W2099795555 @default.
- W2131469090 cites W2105078094 @default.
- W2131469090 cites W2105417592 @default.
- W2131469090 cites W2108442029 @default.
- W2131469090 cites W2116861666 @default.
- W2131469090 cites W2118968952 @default.
- W2131469090 cites W2124070987 @default.
- W2131469090 cites W2124580054 @default.
- W2131469090 cites W2127996002 @default.
- W2131469090 cites W2132272672 @default.
- W2131469090 cites W2141883546 @default.
- W2131469090 cites W2142544310 @default.
- W2131469090 cites W2150124615 @default.
- W2131469090 cites W2151249459 @default.
- W2131469090 cites W2156684669 @default.
- W2131469090 cites W2161765602 @default.
- W2131469090 cites W2162830049 @default.
- W2131469090 cites W2164290357 @default.
- W2131469090 cites W2168341143 @default.
- W2131469090 cites W2168785359 @default.
- W2131469090 cites W2318475756 @default.
- W2131469090 cites W2328615536 @default.
- W2131469090 cites W2605614532 @default.
- W2131469090 cites W4244273098 @default.
- W2131469090 doi "https://doi.org/10.1517/13543770902877717" @default.
- W2131469090 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19441936" @default.
- W2131469090 hasPublicationYear "2009" @default.
- W2131469090 type Work @default.
- W2131469090 sameAs 2131469090 @default.
- W2131469090 citedByCount "37" @default.
- W2131469090 countsByYear W21314690902012 @default.
- W2131469090 countsByYear W21314690902013 @default.
- W2131469090 countsByYear W21314690902014 @default.
- W2131469090 countsByYear W21314690902015 @default.
- W2131469090 countsByYear W21314690902016 @default.
- W2131469090 countsByYear W21314690902017 @default.
- W2131469090 countsByYear W21314690902019 @default.
- W2131469090 countsByYear W21314690902021 @default.
- W2131469090 countsByYear W21314690902022 @default.
- W2131469090 countsByYear W21314690902023 @default.
- W2131469090 crossrefType "journal-article" @default.
- W2131469090 hasAuthorship W2131469090A5040084597 @default.
- W2131469090 hasAuthorship W2131469090A5047196134 @default.
- W2131469090 hasConcept C104317684 @default.
- W2131469090 hasConcept C124490489 @default.
- W2131469090 hasConcept C126322002 @default.