FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2131489495> ?p ?o ?g. }

• W2131489495 endingPage "329" @default.
• W2131489495 startingPage "323" @default.
• W2131489495 abstract "Objective To determine the log-linear relationship between TSH and free thyroxine in healthy subjects, and the variation in baseline TSH/free thyroxine (FT 4 ) combination in each individual. Subjects and methods Twenty-one healthy volunteers (nine males and 12 females; mean age 60 years, range 51–74) were randomized to receive at 2300 h with 2-week intervals a single dose of placebo, 125 μg T 4 and 250 μg T 4 (arm 1, n =10), or placebo, 25 μg triiodothyronine (T 3 ) and 50 μg T 3 (arm 2, n =11). Blood samples were taken in the morning (0800–1100 h) before and following the administration of the drug for the assessment of TSH, FT 4 and T 3 . Results Intra- and inter-individual variation and the individuality index of the four baseline serum samples were respectively 21.6%, 41.9% and 0.52 for TSH; 9.9%, 16.5% and 0.60 for FT 4 ; and 9.3%, 16.0% and 0.58 for T 3 . Substantial differences existed in the location of individual working points within the reference range. T 4 administration increased FT 4 (but not T 3 ) and decreased TSH, resulting in a log-linear relationship (log TSH=1.50–0.059×FT 4 , P <0.05) for the whole group. T 3 administration increased T 3 and decreased TSH (but not FT 4 ), resulting in a log-linear relationship (log TSH=0.790–0.245×T 3 , P <0.001) for the whole group. Log-linear relationships were not always significant when assessed for each subject separately. Conclusion Individuality indices of TSH, FT 4 and T 3 are all ≤0.6, thereby limiting the usefulness of the population-based reference values. Accurate assessment of individual setpoints of the HPT axis was not possible with the applied single doses of T 4 or T 3 , and will require either prolonged administration or higher single doses of thyroid hormone." @default.
• W2131489495 created "2016-06-24" @default.
• W2131489495 creator A5007039126 @default.
• W2131489495 creator A5012141421 @default.
• W2131489495 creator A5036895475 @default.
• W2131489495 creator A5073880325 @default.
• W2131489495 creator A5079797990 @default.
• W2131489495 date "2010-02-01" @default.
• W2131489495 modified "2023-10-18" @default.
• W2131489495 title "Pilot study on the assessment of the setpoint of the hypothalamus–pituitary–thyroid axis in healthy volunteers" @default.
• W2131489495 cites W1952350108 @default.
• W2131489495 cites W1998528306 @default.
• W2131489495 cites W1999060428 @default.
• W2131489495 cites W2021534182 @default.
• W2131489495 cites W2031917944 @default.
• W2131489495 cites W2036501542 @default.
• W2131489495 cites W2045076565 @default.
• W2131489495 cites W2056366718 @default.
• W2131489495 cites W2057348494 @default.
• W2131489495 cites W2066397765 @default.
• W2131489495 cites W2099864259 @default.
• W2131489495 cites W2108218509 @default.
• W2131489495 cites W2123473308 @default.
• W2131489495 cites W2143427348 @default.
• W2131489495 cites W2152373564 @default.
• W2131489495 cites W2154797932 @default.
• W2131489495 cites W2160937120 @default.
• W2131489495 cites W2164276837 @default.
• W2131489495 cites W2316329094 @default.
• W2131489495 cites W2324164337 @default.
• W2131489495 cites W2329436970 @default.
• W2131489495 cites W1918799648 @default.
• W2131489495 cites W3111952814 @default.
• W2131489495 doi "https://doi.org/10.1530/eje-09-0655" @default.
• W2131489495 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19926783" @default.
• W2131489495 hasPublicationYear "2010" @default.
• W2131489495 type Work @default.
• W2131489495 sameAs 2131489495 @default.
• W2131489495 citedByCount "56" @default.
• W2131489495 countsByYear W21314894952012 @default.
• W2131489495 countsByYear W21314894952013 @default.
• W2131489495 countsByYear W21314894952014 @default.
• W2131489495 countsByYear W21314894952015 @default.
• W2131489495 countsByYear W21314894952016 @default.
• W2131489495 countsByYear W21314894952017 @default.
• W2131489495 countsByYear W21314894952018 @default.
• W2131489495 countsByYear W21314894952019 @default.
• W2131489495 countsByYear W21314894952020 @default.
• W2131489495 countsByYear W21314894952021 @default.
• W2131489495 countsByYear W21314894952022 @default.
• W2131489495 countsByYear W21314894952023 @default.
• W2131489495 crossrefType "journal-article" @default.
• W2131489495 hasAuthorship W2131489495A5007039126 @default.
• W2131489495 hasAuthorship W2131489495A5012141421 @default.
• W2131489495 hasAuthorship W2131489495A5036895475 @default.
• W2131489495 hasAuthorship W2131489495A5073880325 @default.
• W2131489495 hasAuthorship W2131489495A5079797990 @default.
• W2131489495 hasConcept C126322002 @default.
• W2131489495 hasConcept C134018914 @default.
• W2131489495 hasConcept C142724271 @default.
• W2131489495 hasConcept C19720800 @default.
• W2131489495 hasConcept C204787440 @default.
• W2131489495 hasConcept C27081682 @default.
• W2131489495 hasConcept C2778143274 @default.
• W2131489495 hasConcept C2778288131 @default.
• W2131489495 hasConcept C526584372 @default.
• W2131489495 hasConcept C71924100 @default.
• W2131489495 hasConceptScore W2131489495C126322002 @default.
• W2131489495 hasConceptScore W2131489495C134018914 @default.
• W2131489495 hasConceptScore W2131489495C142724271 @default.
• W2131489495 hasConceptScore W2131489495C19720800 @default.
• W2131489495 hasConceptScore W2131489495C204787440 @default.
• W2131489495 hasConceptScore W2131489495C27081682 @default.
• W2131489495 hasConceptScore W2131489495C2778143274 @default.
• W2131489495 hasConceptScore W2131489495C2778288131 @default.
• W2131489495 hasConceptScore W2131489495C526584372 @default.
• W2131489495 hasConceptScore W2131489495C71924100 @default.
• W2131489495 hasIssue "2" @default.
• W2131489495 hasLocation W21314894951 @default.
• W2131489495 hasLocation W21314894952 @default.
• W2131489495 hasOpenAccess W2131489495 @default.
• W2131489495 hasPrimaryLocation W21314894951 @default.
• W2131489495 hasRelatedWork W1859326399 @default.
• W2131489495 hasRelatedWork W1973944389 @default.
• W2131489495 hasRelatedWork W1986613353 @default.
• W2131489495 hasRelatedWork W2007125545 @default.
• W2131489495 hasRelatedWork W2258169327 @default.
• W2131489495 hasRelatedWork W2326758290 @default.
• W2131489495 hasRelatedWork W2366618985 @default.
• W2131489495 hasRelatedWork W2748952813 @default.
• W2131489495 hasRelatedWork W2898777440 @default.
• W2131489495 hasRelatedWork W3135850007 @default.
• W2131489495 hasVolume "162" @default.
• W2131489495 isParatext "false" @default.
• W2131489495 isRetracted "false" @default.
• W2131489495 magId "2131489495" @default.
• W2131489495 workType "article" @default.