Matches in SemOpenAlex for { <https://semopenalex.org/work/W2131507796> ?p ?o ?g. }
- W2131507796 endingPage "4961" @default.
- W2131507796 startingPage "4952" @default.
- W2131507796 abstract "ABSTRACT Disruption of eshA , which encodes a 52-kDa protein that is produced late during the growth of Streptomyces coelicolor A3(2), resulted in elimination of actinorhodin production. In contrast, disruption of eshB , a close homologue of eshA , had no effect on antibiotic production. The eshA disruptant accumulated lower levels of ppGpp than the wild-type strain accumulated. The loss of actinorhodin production in the eshA disruptant was restored by expression of a truncated relA gene, which increased the ppGpp level to the level in the wild-type strain, indicating that the reduced ppGpp accumulation in the eshA mutant was solely responsible for the loss of antibiotic production. Antibiotic production was also restored in the eshA mutant by introducing mutations into rpoB (encoding the RNA polymerase β subunit) that bypassed the requirement for ppGpp, which is consistent with a role for EshA in modulating ppGpp levels. EshA contains a cyclic nucleotide-binding domain that is essential for its role in triggering actinorhodin production. EshA may provide new insights and opportunities to unravel the molecular signaling events that occur during physiological differentiation in streptomycetes." @default.
- W2131507796 created "2016-06-24" @default.
- W2131507796 creator A5011446678 @default.
- W2131507796 creator A5039121243 @default.
- W2131507796 creator A5054271905 @default.
- W2131507796 creator A5059886372 @default.
- W2131507796 creator A5074420539 @default.
- W2131507796 creator A5088076962 @default.
- W2131507796 creator A5088736673 @default.
- W2131507796 date "2006-07-01" @default.
- W2131507796 modified "2023-10-16" @default.
- W2131507796 title "EshA Accentuates ppGpp Accumulation and Is Conditionally Required for Antibiotic Production in <i>Streptomyces coelicolor</i> A3(2)" @default.
- W2131507796 cites W1028717280 @default.
- W2131507796 cites W1487066117 @default.
- W2131507796 cites W1520423872 @default.
- W2131507796 cites W1546796120 @default.
- W2131507796 cites W1586044602 @default.
- W2131507796 cites W1830540498 @default.
- W2131507796 cites W1859877474 @default.
- W2131507796 cites W1934677646 @default.
- W2131507796 cites W1939754288 @default.
- W2131507796 cites W1966316616 @default.
- W2131507796 cites W1966823605 @default.
- W2131507796 cites W1971787896 @default.
- W2131507796 cites W1978747627 @default.
- W2131507796 cites W1982491379 @default.
- W2131507796 cites W1985155082 @default.
- W2131507796 cites W1992265335 @default.
- W2131507796 cites W1997470075 @default.
- W2131507796 cites W2002821863 @default.
- W2131507796 cites W2015658684 @default.
- W2131507796 cites W2019081472 @default.
- W2131507796 cites W2026666552 @default.
- W2131507796 cites W2038211892 @default.
- W2131507796 cites W2040804820 @default.
- W2131507796 cites W2056971461 @default.
- W2131507796 cites W2083751896 @default.
- W2131507796 cites W2089445778 @default.
- W2131507796 cites W2091740421 @default.
- W2131507796 cites W2097609672 @default.
- W2131507796 cites W2098139485 @default.
- W2131507796 cites W2099437218 @default.
- W2131507796 cites W2099997990 @default.
- W2131507796 cites W2100481510 @default.
- W2131507796 cites W2108153887 @default.
- W2131507796 cites W2113369444 @default.
- W2131507796 cites W2114206141 @default.
- W2131507796 cites W2114769401 @default.
- W2131507796 cites W2118296945 @default.
- W2131507796 cites W2124926742 @default.
- W2131507796 cites W2127478915 @default.
- W2131507796 cites W2130720166 @default.
- W2131507796 cites W2132100101 @default.
- W2131507796 cites W2139942428 @default.
- W2131507796 cites W2142518090 @default.
- W2131507796 cites W2144415127 @default.
- W2131507796 cites W2148556915 @default.
- W2131507796 cites W2148750992 @default.
- W2131507796 cites W2150267356 @default.
- W2131507796 cites W2150553551 @default.
- W2131507796 cites W2152183144 @default.
- W2131507796 cites W2161155802 @default.
- W2131507796 cites W2163180793 @default.
- W2131507796 cites W2164425579 @default.
- W2131507796 cites W2169062083 @default.
- W2131507796 cites W2171113580 @default.
- W2131507796 cites W2421955228 @default.
- W2131507796 cites W4211047177 @default.
- W2131507796 doi "https://doi.org/10.1128/jb.00343-06" @default.
- W2131507796 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1483009" @default.
- W2131507796 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16788203" @default.
- W2131507796 hasPublicationYear "2006" @default.
- W2131507796 type Work @default.
- W2131507796 sameAs 2131507796 @default.
- W2131507796 citedByCount "33" @default.
- W2131507796 countsByYear W21315077962012 @default.
- W2131507796 countsByYear W21315077962013 @default.
- W2131507796 countsByYear W21315077962014 @default.
- W2131507796 countsByYear W21315077962015 @default.
- W2131507796 countsByYear W21315077962016 @default.
- W2131507796 countsByYear W21315077962017 @default.
- W2131507796 countsByYear W21315077962018 @default.
- W2131507796 countsByYear W21315077962019 @default.
- W2131507796 countsByYear W21315077962020 @default.
- W2131507796 countsByYear W21315077962021 @default.
- W2131507796 countsByYear W21315077962022 @default.
- W2131507796 crossrefType "journal-article" @default.
- W2131507796 hasAuthorship W2131507796A5011446678 @default.
- W2131507796 hasAuthorship W2131507796A5039121243 @default.
- W2131507796 hasAuthorship W2131507796A5054271905 @default.
- W2131507796 hasAuthorship W2131507796A5059886372 @default.
- W2131507796 hasAuthorship W2131507796A5074420539 @default.
- W2131507796 hasAuthorship W2131507796A5088076962 @default.
- W2131507796 hasAuthorship W2131507796A5088736673 @default.
- W2131507796 hasBestOaLocation W21315077962 @default.
- W2131507796 hasConcept C104317684 @default.
- W2131507796 hasConcept C105702510 @default.
- W2131507796 hasConcept C143065580 @default.