Matches in SemOpenAlex for { <https://semopenalex.org/work/W2131515526> ?p ?o ?g. }
- W2131515526 endingPage "606" @default.
- W2131515526 startingPage "600" @default.
- W2131515526 abstract "CA3 pyramidal neurons are important for memory formation and pattern completion in the hippocampal network. It is generally thought that proximal synapses from the mossy fibers activate these neurons most efficiently, whereas distal inputs from the perforant path have a weaker modulatory influence. We used confocally targeted patch-clamp recording from dendrites and axons to map the activation of rat CA3 pyramidal neurons at the subcellular level. Our results reveal two distinct dendritic domains. In the proximal domain, action potentials initiated in the axon backpropagate actively with large amplitude and fast time course. In the distal domain, Na(+) channel-mediated dendritic spikes are efficiently initiated by waveforms mimicking synaptic events. CA3 pyramidal neuron dendrites showed a high Na(+)-to-K(+) conductance density ratio, providing ideal conditions for active backpropagation and dendritic spike initiation. Dendritic spikes may enhance the computational power of CA3 pyramidal neurons in the hippocampal network." @default.
- W2131515526 created "2016-06-24" @default.
- W2131515526 creator A5005437107 @default.
- W2131515526 creator A5062528345 @default.
- W2131515526 creator A5065235989 @default.
- W2131515526 creator A5068410986 @default.
- W2131515526 date "2012-03-04" @default.
- W2131515526 modified "2023-10-16" @default.
- W2131515526 title "Active dendrites support efficient initiation of dendritic spikes in hippocampal CA3 pyramidal neurons" @default.
- W2131515526 cites W1515214283 @default.
- W2131515526 cites W1549050411 @default.
- W2131515526 cites W1571293380 @default.
- W2131515526 cites W1575357711 @default.
- W2131515526 cites W1601216305 @default.
- W2131515526 cites W1735445987 @default.
- W2131515526 cites W1809216657 @default.
- W2131515526 cites W1934624205 @default.
- W2131515526 cites W1967324141 @default.
- W2131515526 cites W1970792572 @default.
- W2131515526 cites W1971618024 @default.
- W2131515526 cites W1974598512 @default.
- W2131515526 cites W1979009696 @default.
- W2131515526 cites W1979073967 @default.
- W2131515526 cites W1983628429 @default.
- W2131515526 cites W1987510656 @default.
- W2131515526 cites W1996456984 @default.
- W2131515526 cites W1997824093 @default.
- W2131515526 cites W2005156903 @default.
- W2131515526 cites W2013880564 @default.
- W2131515526 cites W2015062907 @default.
- W2131515526 cites W2023148260 @default.
- W2131515526 cites W2027205525 @default.
- W2131515526 cites W2035774707 @default.
- W2131515526 cites W2044870013 @default.
- W2131515526 cites W2050032667 @default.
- W2131515526 cites W2054434905 @default.
- W2131515526 cites W2055568369 @default.
- W2131515526 cites W2065416066 @default.
- W2131515526 cites W2072233684 @default.
- W2131515526 cites W2073055671 @default.
- W2131515526 cites W2073818625 @default.
- W2131515526 cites W2090584164 @default.
- W2131515526 cites W2096424464 @default.
- W2131515526 cites W2096916130 @default.
- W2131515526 cites W2098595367 @default.
- W2131515526 cites W2102064756 @default.
- W2131515526 cites W2109161455 @default.
- W2131515526 cites W2110016065 @default.
- W2131515526 cites W2110402020 @default.
- W2131515526 cites W2113770179 @default.
- W2131515526 cites W2119051448 @default.
- W2131515526 cites W2120610786 @default.
- W2131515526 cites W2130074917 @default.
- W2131515526 cites W2134351637 @default.
- W2131515526 cites W2140885691 @default.
- W2131515526 cites W2147101007 @default.
- W2131515526 cites W2157210082 @default.
- W2131515526 cites W2337604471 @default.
- W2131515526 cites W2416148029 @default.
- W2131515526 cites W4213023152 @default.
- W2131515526 cites W4255658673 @default.
- W2131515526 doi "https://doi.org/10.1038/nn.3060" @default.
- W2131515526 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3617474" @default.
- W2131515526 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22388958" @default.
- W2131515526 hasPublicationYear "2012" @default.
- W2131515526 type Work @default.
- W2131515526 sameAs 2131515526 @default.
- W2131515526 citedByCount "70" @default.
- W2131515526 countsByYear W21315155262012 @default.
- W2131515526 countsByYear W21315155262013 @default.
- W2131515526 countsByYear W21315155262014 @default.
- W2131515526 countsByYear W21315155262015 @default.
- W2131515526 countsByYear W21315155262016 @default.
- W2131515526 countsByYear W21315155262017 @default.
- W2131515526 countsByYear W21315155262018 @default.
- W2131515526 countsByYear W21315155262019 @default.
- W2131515526 countsByYear W21315155262020 @default.
- W2131515526 countsByYear W21315155262021 @default.
- W2131515526 countsByYear W21315155262022 @default.
- W2131515526 countsByYear W21315155262023 @default.
- W2131515526 crossrefType "journal-article" @default.
- W2131515526 hasAuthorship W2131515526A5005437107 @default.
- W2131515526 hasAuthorship W2131515526A5062528345 @default.
- W2131515526 hasAuthorship W2131515526A5065235989 @default.
- W2131515526 hasAuthorship W2131515526A5068410986 @default.
- W2131515526 hasBestOaLocation W21315155262 @default.
- W2131515526 hasConcept C112592302 @default.
- W2131515526 hasConcept C147944092 @default.
- W2131515526 hasConcept C148762608 @default.
- W2131515526 hasConcept C169760540 @default.
- W2131515526 hasConcept C17077164 @default.
- W2131515526 hasConcept C174884520 @default.
- W2131515526 hasConcept C185263204 @default.
- W2131515526 hasConcept C185592680 @default.
- W2131515526 hasConcept C2524010 @default.
- W2131515526 hasConcept C2776168963 @default.
- W2131515526 hasConcept C2776464000 @default.
- W2131515526 hasConcept C2778437258 @default.