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W2131525679 abstract "Abstract Angiogenesis is an important host process that interacts with cancer cells to promote growth, invasion, and metastasis. Numerous therapeutic agents targeting the VEGF pathway have been developed. Host variability in VEGF pathway can influence angiogenesis-dependent signaling, altering sensitivity to antiangiogenic drugs and prognosis. A systematic review and meta-analysis was conducted (May 1990–July 2011). Eligible studies involved cancer patients and compared polymorphisms in the VEGF pathway [VEGF and molecules directly interacting with VEGF: KDR, FLT1, FGF, FGF2, FGFR, NRP1, endostatin (encoded by COL18A1)], and reported one of the following outcomes: overall survival, progression-free survival, time to recurrence, disease-free survival, response rate, or drug toxicity. We identified 48 cancer studies assessing prognosis and 12 cancer studies exploring pharmacogenetics of anti-VEGF therapy across various VEGF pathway polymorphisms. There was marked inter- and intradisease site heterogeneity in the effect of polymorphisms on both outcome and response to therapy. Meta-analyses of 5 VEGF polymorphisms (+936C>T, −460T>C, +405G>C, −1154G>A, and −2578C>A) identified a significant prognostic relationship: VEGF +405G>C variants showed a highly statistically significant improvement in overall survival [HR, 0.74; 95% confidence interval, 0.60–0.91; P = 0.004]. Variants (heterozygotes and/or homozygotes) of VEGF +405G>C were significantly associated with improved survival in a meta-analysis of multiple cancer sites. Clin Cancer Res; 18(17); 4526–37. ©2012 AACR." @default.
W2131525679 created "2016-06-24" @default.
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W2131525679 date "2012-08-30" @default.
W2131525679 modified "2023-10-16" @default.
W2131525679 title "Vascular Endothelial Growth Factor Pathway Polymorphisms as Prognostic and Pharmacogenetic Factors in Cancer: A Systematic Review and Meta-analysis" @default.
W2131525679 cites W1630248744 @default.
W2131525679 cites W1968796614 @default.
W2131525679 cites W1970344706 @default.
W2131525679 cites W1975925353 @default.
W2131525679 cites W1977299026 @default.
W2131525679 cites W1989085484 @default.
W2131525679 cites W1990199438 @default.
W2131525679 cites W1992553649 @default.
W2131525679 cites W1997509442 @default.
W2131525679 cites W2000315161 @default.
W2131525679 cites W2012393069 @default.
W2131525679 cites W2016478231 @default.
W2131525679 cites W2017487279 @default.
W2131525679 cites W2018670837 @default.
W2131525679 cites W2018761135 @default.
W2131525679 cites W2031166705 @default.
W2131525679 cites W2033306593 @default.
W2131525679 cites W2034465826 @default.
W2131525679 cites W2036543296 @default.
W2131525679 cites W2037094200 @default.
W2131525679 cites W2038645347 @default.
W2131525679 cites W2045661532 @default.
W2131525679 cites W2053825700 @default.
W2131525679 cites W2069908482 @default.
W2131525679 cites W2075154602 @default.
W2131525679 cites W2081833489 @default.
W2131525679 cites W2082636029 @default.
W2131525679 cites W2082795590 @default.
W2131525679 cites W2091849639 @default.
W2131525679 cites W2093579014 @default.
W2131525679 cites W2095435077 @default.
W2131525679 cites W2098738258 @default.
W2131525679 cites W2100971079 @default.
W2131525679 cites W2107328434 @default.
W2131525679 cites W2107783310 @default.
W2131525679 cites W2111459991 @default.
W2131525679 cites W2111752325 @default.
W2131525679 cites W2112079667 @default.
W2131525679 cites W2117087331 @default.
W2131525679 cites W2119865588 @default.
W2131525679 cites W2119973757 @default.
W2131525679 cites W2120243407 @default.
W2131525679 cites W2120384717 @default.
W2131525679 cites W2120638451 @default.
W2131525679 cites W2127159621 @default.
W2131525679 cites W2130493310 @default.
W2131525679 cites W2131209749 @default.
W2131525679 cites W2131705241 @default.
W2131525679 cites W2132462429 @default.
W2131525679 cites W2136340911 @default.
W2131525679 cites W2136991389 @default.
W2131525679 cites W2140060467 @default.
W2131525679 cites W2142397568 @default.
W2131525679 cites W2147704921 @default.
W2131525679 cites W2149254095 @default.
W2131525679 cites W2149416256 @default.
W2131525679 cites W2153186785 @default.
W2131525679 cites W2157181877 @default.
W2131525679 cites W2158955681 @default.
W2131525679 cites W2160069147 @default.
W2131525679 cites W2160211542 @default.
W2131525679 cites W2160920221 @default.
W2131525679 cites W2163713521 @default.
W2131525679 cites W2167132472 @default.
W2131525679 cites W2167927601 @default.
W2131525679 cites W2168871518 @default.
W2131525679 cites W2171161010 @default.
W2131525679 cites W2217809488 @default.
W2131525679 cites W2330390126 @default.
W2131525679 doi "https://doi.org/10.1158/1078-0432.ccr-12-1315" @default.
W2131525679 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22733538" @default.
W2131525679 hasPublicationYear "2012" @default.
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