FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2131527529> ?p ?o ?g. }

• W2131527529 endingPage "30246" @default.
• W2131527529 startingPage "30233" @default.
• W2131527529 abstract "Insulin-like growth factor-binding protein-3 (IGFBP-3), a major regulator of endocrine actions of IGFs, is a p53-regulated potent apoptotic factor and is significantly suppressed in a variety of cancers. Recent epidemiologic studies suggest that IGFBP-3 contributes to cancer risk protection in a variety of cancers, and a polymorphic variation of IGFBP-3 influences cancer risk, although other studies vary in their conclusions. Some antiproliferative actions of IGFBP-3 have been reported to be independent of IGFs, but the precise biochemical/molecular mechanisms of IGF-independent, antiproliferative actions of IGFBP-3 are largely unknown. Here we report a new cell death receptor, IGFBP-3R, that is a single-span membrane protein and binds specifically to IGFBP-3 but not other IGFBP species. Expression analysis of IGFBP-3 and IGFBP-3R indicates that the IGFBP-3/IGFBP-3R axis is impaired in breast and prostate cancer. We also provide evidence for anti-tumor effect of IGFBP-3R in vivo using prostate and breast cancer xenografts in athymic nude mice. Further in vitro studies demonstrate that IGFBP-3R mediates IGFBP-3-induced caspase-8-dependent apoptosis in various cancer cells. Knockdown of IGFBP-3R attenuated IGFBP-3-induced caspase activities and apoptosis, whereas overexpression of IGFBP-3R enhanced IGFBP-3 biological effects. IGFBP-3R physically interacts and activates caspase-8, and knockdown of caspase-8 expression or activity inhibited IGFBP-3/IGFBP-3R-induced apoptosis. Here, we propose that IGFBP-3R represents a novel cell death receptor and is essential for the IGFBP-3-induced apoptosis and tumor suppression. Thus, the IGFBP-3/IGFBP-3R axis may provide therapeutic and prognostic value for the treatment of cancer." @default.
• W2131527529 created "2016-06-24" @default.
• W2131527529 creator A5000176573 @default.
• W2131527529 creator A5003812658 @default.
• W2131527529 creator A5010730387 @default.
• W2131527529 creator A5020110586 @default.
• W2131527529 creator A5022471764 @default.
• W2131527529 creator A5031163211 @default.
• W2131527529 creator A5051129068 @default.
• W2131527529 creator A5054991371 @default.
• W2131527529 creator A5056791334 @default.
• W2131527529 creator A5075821962 @default.
• W2131527529 creator A5083615070 @default.
• W2131527529 creator A5089560306 @default.
• W2131527529 date "2010-09-01" @default.
• W2131527529 modified "2023-10-01" @default.
• W2131527529 title "Identification of a Novel Cell Death Receptor Mediating IGFBP-3-induced Anti-tumor Effects in Breast and Prostate Cancer" @default.
• W2131527529 cites W1481362782 @default.
• W2131527529 cites W1964573360 @default.
• W2131527529 cites W1978008638 @default.
• W2131527529 cites W1983987321 @default.
• W2131527529 cites W1993310622 @default.
• W2131527529 cites W1993563907 @default.
• W2131527529 cites W1996857055 @default.
• W2131527529 cites W2004487378 @default.
• W2131527529 cites W2007228548 @default.
• W2131527529 cites W2010363122 @default.
• W2131527529 cites W2012505775 @default.
• W2131527529 cites W2016259832 @default.
• W2131527529 cites W2019329034 @default.
• W2131527529 cites W2020368904 @default.
• W2131527529 cites W2020589003 @default.
• W2131527529 cites W2023458566 @default.
• W2131527529 cites W2024410864 @default.
• W2131527529 cites W2026095724 @default.
• W2131527529 cites W2027454234 @default.
• W2131527529 cites W2028171591 @default.
• W2131527529 cites W2037945409 @default.
• W2131527529 cites W2053736927 @default.
• W2131527529 cites W2060217146 @default.
• W2131527529 cites W2060415047 @default.
• W2131527529 cites W2064651108 @default.
• W2131527529 cites W2077956417 @default.
• W2131527529 cites W2091270752 @default.
• W2131527529 cites W2095385109 @default.
• W2131527529 cites W2106781900 @default.
• W2131527529 cites W2115417003 @default.
• W2131527529 cites W2115850999 @default.
• W2131527529 cites W2117820574 @default.
• W2131527529 cites W2128675390 @default.
• W2131527529 cites W2140491527 @default.
• W2131527529 cites W2140686252 @default.
• W2131527529 cites W2141369667 @default.
• W2131527529 cites W2156406678 @default.
• W2131527529 cites W2164617509 @default.
• W2131527529 cites W2172162633 @default.
• W2131527529 doi "https://doi.org/10.1074/jbc.m110.122226" @default.
• W2131527529 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2943278" @default.
• W2131527529 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20353938" @default.
• W2131527529 hasPublicationYear "2010" @default.
• W2131527529 type Work @default.
• W2131527529 sameAs 2131527529 @default.
• W2131527529 citedByCount "109" @default.
• W2131527529 countsByYear W21315275292012 @default.
• W2131527529 countsByYear W21315275292013 @default.
• W2131527529 countsByYear W21315275292014 @default.
• W2131527529 countsByYear W21315275292015 @default.
• W2131527529 countsByYear W21315275292016 @default.
• W2131527529 countsByYear W21315275292017 @default.
• W2131527529 countsByYear W21315275292018 @default.
• W2131527529 countsByYear W21315275292019 @default.
• W2131527529 countsByYear W21315275292020 @default.
• W2131527529 countsByYear W21315275292021 @default.
• W2131527529 countsByYear W21315275292022 @default.
• W2131527529 countsByYear W21315275292023 @default.
• W2131527529 crossrefType "journal-article" @default.
• W2131527529 hasAuthorship W2131527529A5000176573 @default.
• W2131527529 hasAuthorship W2131527529A5003812658 @default.
• W2131527529 hasAuthorship W2131527529A5010730387 @default.
• W2131527529 hasAuthorship W2131527529A5020110586 @default.
• W2131527529 hasAuthorship W2131527529A5022471764 @default.
• W2131527529 hasAuthorship W2131527529A5031163211 @default.
• W2131527529 hasAuthorship W2131527529A5051129068 @default.
• W2131527529 hasAuthorship W2131527529A5054991371 @default.
• W2131527529 hasAuthorship W2131527529A5056791334 @default.
• W2131527529 hasAuthorship W2131527529A5075821962 @default.
• W2131527529 hasAuthorship W2131527529A5083615070 @default.
• W2131527529 hasAuthorship W2131527529A5089560306 @default.
• W2131527529 hasBestOaLocation W21315275291 @default.
• W2131527529 hasConcept C121608353 @default.
• W2131527529 hasConcept C126322002 @default.
• W2131527529 hasConcept C134018914 @default.
• W2131527529 hasConcept C170493617 @default.
• W2131527529 hasConcept C173396325 @default.
• W2131527529 hasConcept C190283241 @default.
• W2131527529 hasConcept C2775960820 @default.
• W2131527529 hasConcept C2776235491 @default.
• W2131527529 hasConcept C2780192828 @default.

• next