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- W2131567382 abstract "FEWER THAN 25% OF WOMEN experience a symptom-free menopausal transition and over 25% suffer severe symptoms most commonly vasomotor events. Non-pharmaceutical approaches such as paced respiration have been shown to reduce the severity and frequency of vasomotor symptoms but are of no use in preventing symptoms that disturb sleep. A multitude of over-the-counter preparations are used by menopausal women for symptom relief but are of varying quality and some have been shown to be no better than placebo for symptom management. Of concern is the potential for side effects with several cases of acute hepatitis reported after use of black cohosh and other common herbal remedies. Postmenopausal oestrogen therapy effectively alleviates menopause symptoms prevents osteoporotic fractures and possibly reduces the risk of bowel cancer. However there are justifiable concerns about the safety of available regimens. Oestrogen given alone to women with an intact uterus significantly increases uterine cancer risk while oral oestrogen–progestin regimens used for more than 5 years have been reported to increase breast cancer risk. The latter regimens have also been associated with increased risk of venous thromboembolic and cardiovascular events. (excerpt)" @default.
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- W2131567382 date "2003-06-01" @default.
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- W2131567382 title "Menopause: new therapies" @default.
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- W2131567382 doi "https://doi.org/10.5694/j.1326-5377.2003.tb05391.x" @default.
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