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- W2131567992 abstract "Male and female rats were segregated from birth (sexually isolated animals). Additional litters containing both male and female pups were kept as controls (mixed-housed animals). β-FNA (5 mg/kg) or water was administered SC at day 0 or day 7 to isolated and mixed-housed animals. The development of μ-opioid receptors and nociceptive responses in the two groups was assessed at day 7 or 14, respectively. Mu-receptor binding was measured in whole brain using (3H) DAGO as a binding ligand and nociception assessed using the tail immersion test. β-FNA treatment depressed μ-receptors when measured 1 but not 7 days later. However, male and female rats treated at day 0 with β-FNA had lower brain protein content. Sexual isolation had little effect on μ-receptor number and did not augment the β-FNA effect. However, isolation increased pain sensitivity in 7-day-old animals and in 14-day-old females. β-FNA treatment had little effect on nociceptive threshold but reversed the effects of sexual isolation." @default.
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- W2131567992 date "1993-01-01" @default.
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- W2131567992 title "Effects of β-funaltrexamine treatment and sexual isolation in the perinatal period on the development of μ-opioid receptors and nociception" @default.
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- W2131567992 doi "https://doi.org/10.1016/0306-4530(93)90016-e" @default.
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