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- W2131569286 abstract "Significance Chickens have been an important animal model in the fields of developmental biology and immunology over the last century and have contributed a number of basic findings in these areas. However, their use has been limited more recently because there has been no way to genetically engineer specific mutations in the chicken. In addition to basic research applications, genetic modification in birds could also be used to mitigate the threat of avian influenza by production of flu-resistant bird stocks in agriculture. Here we describe an efficient way to target genes of interest in the chicken genome and create knockout chickens. We targeted the immunoglobulin heavy chain gene, leading to loss of antibody production and a block in B-cell development." @default.
- W2131569286 created "2016-06-24" @default.
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- W2131569286 date "2013-11-26" @default.
- W2131569286 modified "2023-09-22" @default.
- W2131569286 title "Immunoglobulin knockout chickens via efficient homologous recombination in primordial germ cells" @default.
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- W2131569286 doi "https://doi.org/10.1073/pnas.1317106110" @default.
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