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• W2131569696 endingPage "1364" @default.
• W2131569696 startingPage "1355" @default.
• W2131569696 abstract "The medicinal benefits of Allium vegetables, especially garlic, have been noted throughout recorded history. The known health benefits of Allium vegetables and their constituents include cardiovascular protective effects, stimulation of immune function, reduction of blood glucose level, radioprotection, improvement of memory loss, protection against microbial, viral and fungal infections, as well as anticancer effects. Population-based case control studies have suggested an inverse correlation between dietary intake of Allium vegetables and the risk of different types of cancers. The anticarcinogenic effect of Allium vegetables including garlic is attributed to organosulfur compounds (OSC), which are highly effective in affording protection against cancer in animal models induced by a variety of chemical carcinogens. More recent studies have shown that certain naturally occurring OSC analogues can suppress proliferation of cancer cells in culture and in vivo. The OSC-induced changes in the proliferation of cancer cells are frequently associated with perturbations in cell cycle progression and induction of G2/M phase arrest. The OSC have also been demonstrated to induce apoptosis via the intrinsic pathway by altering the ratio of the Bcl-2 family of proteins both in cell culture and in in vivo models. Anti-angiogenic activity for garlic-derived OSC has also been documented. This article summarizes current knowledge on molecular targets of cancer chemoprevention by OSC." @default.
• W2131569696 created "2016-06-24" @default.
• W2131569696 creator A5022304953 @default.
• W2131569696 creator A5035350094 @default.
• W2131569696 creator A5086032223 @default.
• W2131569696 date "2007-09-01" @default.
• W2131569696 modified "2023-10-15" @default.
• W2131569696 title "Molecular targets of cancer chemoprevention by garlic-derived organosulfides" @default.
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• W2131569696 doi "https://doi.org/10.1111/j.1745-7254.2007.00682.x" @default.
• W2131569696 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17723169" @default.
• W2131569696 hasPublicationYear "2007" @default.
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