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• W2131575325 endingPage "7516" @default.
• W2131575325 startingPage "7504" @default.
• W2131575325 abstract "ABSTRACT Poliovirus (PV) is the causal agent of paralytic poliomyelitis, a disease that involves the destruction of motor neurons associated with PV replication. In PV-infected mice, motor neurons die through an apoptotic process. However, mechanisms by which PV induces cell death in neuronal cells remain unclear. Here, we demonstrate that PV infection of neuronal IMR5 cells induces cytochrome c release from mitochondria and loss of mitochondrial transmembrane potential, both of which are evidence of mitochondrial outer membrane permeabilization. PV infection also activates Bax, a proapoptotic member of the Bcl-2 family; this activation involves its conformational change and its redistribution from the cytosol to mitochondria. Neutralization of Bax by vMIA protein expression prevents cytochrome c release, consistent with a contribution of PV-induced Bax activation to mitochondrial outer membrane permeabilization. Interestingly, we also found that c-Jun NH 2 -terminal kinase (JNK) is activated soon after PV infection and that the PV-cell receptor interaction alone is sufficient to induce JNK activation. Moreover, the pharmacological inhibition of JNK by SP600125 inhibits Bax activation and cytochrome c release. This is, to our knowledge, the first demonstration of JNK-mediated Bax-dependent apoptosis in PV-infected cells. Our findings contribute to our understanding of poliomyelitis pathogenesis at the cellular level." @default.
• W2131575325 created "2016-06-24" @default.
• W2131575325 creator A5005171419 @default.
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• W2131575325 creator A5089806133 @default.
• W2131575325 creator A5091079663 @default.
• W2131575325 date "2007-07-15" @default.
• W2131575325 modified "2023-10-16" @default.
• W2131575325 title "Poliovirus Induces Bax-Dependent Cell Death Mediated by c-Jun NH ₂ -Terminal Kinase" @default.
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• W2131575325 doi "https://doi.org/10.1128/jvi.02690-06" @default.
• W2131575325 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1933371" @default.
• W2131575325 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17494073" @default.
• W2131575325 hasPublicationYear "2007" @default.
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