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- W2131584266 abstract "Omeprazole represents the first agent of a unique class of acid inhibitory drugs, the proton pump inhibitors. Omeprazole inhibits basal gastric acid secretion, as well as gastrin-, histamine-, or pentagastrin-stimulated secretion, which results in decreased gastric acidity, decreased gastric acid output, and decreased gastric volume. Omeprazole is acid labile, necessitating its oral administration in an enteric-coated formulation. Bioavailability appears to be dose-dependent, with more drug being absorbed with increasing dosage as well as after repeated dosing. This is probably secondary to decreased gastric acidity and, therefore, less degradation of the administered drug. Despite its relatively short half-life (1-2 h), omeprazole's pharmacologic action is prolonged. Clinical trials have shown omeprazole to be at least as effective as histamine2-receptor antagonists in the treatment of gastric ulcers, duodenal ulcers, gastroesophageal reflux, and Zollinger-Ellison syndrome. Adverse reactions have been minimal. Omeprazole has been approved by the Food and Drug Administration for short-term therapy of severe erosive esophagitis, poorly responsive symptomatic gastroesophageal reflux disease, and long-term management of Zollinger-Ellison syndrome." @default.
- W2131584266 created "2016-06-24" @default.
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- W2131584266 date "1990-04-01" @default.
- W2131584266 modified "2023-09-27" @default.
- W2131584266 title "Omeprazole: A Novel Antisecretory Agent for the Treatment of Acid-Peptic Disorders" @default.
- W2131584266 cites W122184333 @default.
- W2131584266 cites W1497912223 @default.
- W2131584266 cites W1519058182 @default.
- W2131584266 cites W1530382242 @default.
- W2131584266 cites W1582962150 @default.
- W2131584266 cites W182983472 @default.
- W2131584266 cites W1971574217 @default.
- W2131584266 cites W1974456015 @default.
- W2131584266 cites W1974801243 @default.
- W2131584266 cites W1983447573 @default.
- W2131584266 cites W1984018033 @default.
- W2131584266 cites W1985499927 @default.
- W2131584266 cites W1994308976 @default.
- W2131584266 cites W1995779830 @default.
- W2131584266 cites W1996284297 @default.
- W2131584266 cites W1996707302 @default.
- W2131584266 cites W1997354672 @default.
- W2131584266 cites W2003665847 @default.
- W2131584266 cites W2004084174 @default.
- W2131584266 cites W2004105895 @default.
- W2131584266 cites W2005129208 @default.
- W2131584266 cites W2011311791 @default.
- W2131584266 cites W2011995387 @default.
- W2131584266 cites W2013371242 @default.
- W2131584266 cites W2016891497 @default.
- W2131584266 cites W2017431068 @default.
- W2131584266 cites W2018925643 @default.
- W2131584266 cites W2022126210 @default.
- W2131584266 cites W203119193 @default.
- W2131584266 cites W2032038267 @default.
- W2131584266 cites W2033340618 @default.
- W2131584266 cites W2034585388 @default.
- W2131584266 cites W2035452015 @default.
- W2131584266 cites W2038110081 @default.
- W2131584266 cites W2038496924 @default.
- W2131584266 cites W2039647112 @default.
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- W2131584266 cites W2047468111 @default.
- W2131584266 cites W2047644905 @default.
- W2131584266 cites W2048702787 @default.
- W2131584266 cites W2051951493 @default.
- W2131584266 cites W2055332531 @default.
- W2131584266 cites W2057305216 @default.
- W2131584266 cites W2064194125 @default.
- W2131584266 cites W2064972305 @default.
- W2131584266 cites W2069444177 @default.
- W2131584266 cites W2069791811 @default.
- W2131584266 cites W2069962557 @default.
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- W2131584266 cites W2071312846 @default.
- W2131584266 cites W2072760263 @default.
- W2131584266 cites W2078732261 @default.
- W2131584266 cites W2086422928 @default.
- W2131584266 cites W2088203121 @default.
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- W2131584266 cites W2125597970 @default.
- W2131584266 cites W2136894785 @default.
- W2131584266 cites W2136974472 @default.
- W2131584266 cites W2143953542 @default.
- W2131584266 cites W2151461746 @default.
- W2131584266 cites W2168234648 @default.
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- W2131584266 cites W2413868293 @default.
- W2131584266 cites W2418864944 @default.
- W2131584266 cites W2801904289 @default.
- W2131584266 cites W4241369409 @default.
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- W2131584266 doi "https://doi.org/10.1177/106002809002400411" @default.
- W2131584266 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2183494" @default.
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