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• W2131587234 endingPage "15" @default.
• W2131587234 startingPage "1" @default.
• W2131587234 abstract "Hepatitis B and C often progress to decompensated liver cirrhosis requiring orthotopic liver transplantation (OLT). After OLT, hepatitis B recurrence is clinically controlled with a combination of hepatitis B immunoglobulin (HBIG) and nucleos(t)ide analogues. Another approach is to induce self-producing anti-hepatitis B virus (HBV) antibodies using a HBV envelope antigen vaccine. Patients who had not been HBV carriers such as acutely infected liver failure or who received liver from HBV self-limited donor are good candidate. For chronic HBV carrier patients, a successful response can only be achieved in selected patients such as those treated with experimentally reduced immunosuppression protocols or received an anti-HBV adaptive memory carrying donor liver. Hepatitis C virus (HCV) reinfects transplanted livers at a rate of >90%. HCV reinfected patients show different severities of hepatitis, from mild and slowly progressing to severe and rapidly progressing, possibly resulting from different adaptive immune responses. More than half the patients require interferon treatment, although the success rate is low and carries risks for leukocytopenia and rejection. Managing the immune response has an important role in controlling recurrent hepatitis C. This study aimed to review the adaptive immune response in post-OLT hepatitis B and C." @default.
• W2131587234 created "2016-06-24" @default.
• W2131587234 creator A5039413936 @default.
• W2131587234 creator A5065713817 @default.
• W2131587234 creator A5089636709 @default.
• W2131587234 date "2014-01-01" @default.
• W2131587234 modified "2023-10-16" @default.
• W2131587234 title "Contradictory Immune Response in Post Liver Transplantation Hepatitis B and C" @default.
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