FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2131588713> ?p ?o ?g. }

• W2131588713 endingPage "n/a" @default.
• W2131588713 startingPage "n/a" @default.
• W2131588713 abstract "Parkinson's disease (PD) is a neurodegenerative disease characterized by progressive degeneration of nigrostriatal dopaminergic (DA) neurons. The therapeutic potential of glial cell line-derived neurotrophic factor (GDNF), the most potent neurotrophic factor for DA neurons, has been demonstrated in many experimental models of PD. However, chronic delivery of GDNF to DA neurons in the brain remains an unmet challenge. Here, we report the effects of GDNF-releasing Notch-induced human bone marrow-derived mesenchymal stem cells (MSC) grafted into striatum of the 6-hydroxydopamine (6-OHDA) progressively lesioned rat model of PD. Human MSC, obtained from bone marrow aspirates of young, healthy adult volunteers, were transiently transfected with the intracellular domain of the Notch1 gene (NICD) to generate SB623 cells. SB623 cells expressing GDNF and/or humanized Renilla green fluorescent protein (hrGFP) following lentiviral transduction or nontransduced cells were stereotaxically placed into rat striatum 1 week after a unilateral partial 6-OHDA striatal lesion. At 4 weeks, rats that had received GDNF-transduced SB623 cells had significantly decreased amphetamine-induced rotation compared with control rats, although this effect was not observed in rats that received GFP-transduced or nontransduced SB623 cells. At 5 weeks, rejuvenated tyrosine hydroxylase-immunoreactive (TH-IR) fibers that appeared to be host DA axons were observed in and around grafts. This effect was more prominent in rats that received GDNF-secreting cells and was not observed in controls. These observations suggest that human bone-marrow derived MSC, genetically modified to secrete GDNF, hold potential as an allogeneic or autologous stem cell therapy for PD. © 2010 Wiley-Liss, Inc." @default.
• W2131588713 created "2016-06-24" @default.
• W2131588713 creator A5005832685 @default.
• W2131588713 creator A5012991123 @default.
• W2131588713 creator A5027781323 @default.
• W2131588713 creator A5046883964 @default.
• W2131588713 creator A5084283465 @default.
• W2131588713 creator A5091047667 @default.
• W2131588713 date "2010-06-11" @default.
• W2131588713 modified "2023-10-18" @default.
• W2131588713 title "Glial cell line-derived neurotrophic factor-secreting genetically modified human bone marrow-derived mesenchymal stem cells promote recovery in a rat model of Parkinson's disease" @default.
• W2131588713 cites W1548750032 @default.
• W2131588713 cites W1650719874 @default.
• W2131588713 cites W1718365317 @default.
• W2131588713 cites W1804407417 @default.
• W2131588713 cites W1971017960 @default.
• W2131588713 cites W1971053395 @default.
• W2131588713 cites W1971258758 @default.
• W2131588713 cites W1973028673 @default.
• W2131588713 cites W1973649320 @default.
• W2131588713 cites W1976632859 @default.
• W2131588713 cites W1977294102 @default.
• W2131588713 cites W1981287437 @default.
• W2131588713 cites W1983969839 @default.
• W2131588713 cites W1985069671 @default.
• W2131588713 cites W1985508547 @default.
• W2131588713 cites W1986592378 @default.
• W2131588713 cites W1987145582 @default.
• W2131588713 cites W1988463041 @default.
• W2131588713 cites W1991062038 @default.
• W2131588713 cites W1991208841 @default.
• W2131588713 cites W1991719688 @default.
• W2131588713 cites W1992618202 @default.
• W2131588713 cites W1996001296 @default.
• W2131588713 cites W1996970388 @default.
• W2131588713 cites W2001361641 @default.
• W2131588713 cites W2001477976 @default.
• W2131588713 cites W2003612554 @default.
• W2131588713 cites W2005848913 @default.
• W2131588713 cites W2007890661 @default.
• W2131588713 cites W2012205272 @default.
• W2131588713 cites W2015167814 @default.
• W2131588713 cites W2026246891 @default.
• W2131588713 cites W2027197900 @default.
• W2131588713 cites W2028311590 @default.
• W2131588713 cites W2030645047 @default.
• W2131588713 cites W2032281007 @default.
• W2131588713 cites W2033154396 @default.
• W2131588713 cites W2035521667 @default.
• W2131588713 cites W2035537485 @default.
• W2131588713 cites W2039779463 @default.
• W2131588713 cites W2041455189 @default.
• W2131588713 cites W2041571943 @default.
• W2131588713 cites W2041676728 @default.
• W2131588713 cites W2043458930 @default.
• W2131588713 cites W2047570521 @default.
• W2131588713 cites W2049393626 @default.
• W2131588713 cites W2049494700 @default.
• W2131588713 cites W2050636568 @default.
• W2131588713 cites W2052956756 @default.
• W2131588713 cites W2054438521 @default.
• W2131588713 cites W2054507508 @default.
• W2131588713 cites W2054810445 @default.
• W2131588713 cites W2056285623 @default.
• W2131588713 cites W2057159662 @default.
• W2131588713 cites W2059066863 @default.
• W2131588713 cites W2061473541 @default.
• W2131588713 cites W2063893203 @default.
• W2131588713 cites W2065000444 @default.
• W2131588713 cites W2070542281 @default.
• W2131588713 cites W2071360006 @default.
• W2131588713 cites W2074432223 @default.
• W2131588713 cites W2075997145 @default.
• W2131588713 cites W2076686536 @default.
• W2131588713 cites W2076892678 @default.
• W2131588713 cites W2079014632 @default.
• W2131588713 cites W2079365545 @default.
• W2131588713 cites W2079935484 @default.
• W2131588713 cites W2081915484 @default.
• W2131588713 cites W2083628520 @default.
• W2131588713 cites W2085935458 @default.
• W2131588713 cites W2087081786 @default.
• W2131588713 cites W2088218095 @default.
• W2131588713 cites W2089839531 @default.
• W2131588713 cites W2093377304 @default.
• W2131588713 cites W2094635970 @default.
• W2131588713 cites W2095101532 @default.
• W2131588713 cites W2095666785 @default.
• W2131588713 cites W2100975089 @default.
• W2131588713 cites W2103612759 @default.
• W2131588713 cites W2103899142 @default.
• W2131588713 cites W2104793567 @default.
• W2131588713 cites W2108724455 @default.
• W2131588713 cites W2130620253 @default.
• W2131588713 cites W2139941185 @default.
• W2131588713 cites W2142594288 @default.
• W2131588713 cites W2145050029 @default.
• W2131588713 cites W2146092469 @default.

• next