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• W2131592022 abstract "The pro-inflammatory cytokine interleukin (IL)-1β is a clinical target in many conditions involving dysregulation of the immune system; therapeutics that block IL-1β have been approved to treat diseases such as rheumatoid arthritis (RA), neonatal onset multisystem inflammatory diseases, cryopyrin-associated periodic syndromes, active systemic juvenile idiopathic arthritis. Here, we report the generation and engineering of a new fully human antibody that binds tightly to IL-1β with a neutralization potency more than 10 times higher than that of the marketed antibody canakinumab. After affinity maturation, the derived antibody shows a >30-fold increased affinity to human IL-1β compared with its parent antibody. This anti-human IL-1β IgG also cross-reacts with mouse and monkey IL-1β, hence facilitating preclinical development. In a number of mouse models, this antibody efficiently reduced or abolished signs of disease associated with IL-1β pathology. Due to its high affinity for the cytokine and its potency both in vitro and in vivo, we propose that this novel fully human anti-IL-1β monoclonal antibody is a promising therapeutic candidate and a potential alternative to the current therapeutic arsenal." @default.
• W2131592022 created "2016-06-24" @default.
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• W2131592022 date "2014-03-26" @default.
• W2131592022 modified "2023-09-26" @default.
• W2131592022 title "A novel human anti-interleukin-1β neutralizing monoclonal antibody showing in vivo efficacy" @default.
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• W2131592022 doi "https://doi.org/10.4161/mabs.28614" @default.
• W2131592022 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4011920" @default.
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