FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2131595296> ?p ?o ?g. }

• W2131595296 endingPage "93" @default.
• W2131595296 startingPage "687" @default.
• W2131595296 abstract "The aim of this retrospective study was to assess whether p53 gene status has any predictive or prognostic relevance in patients with advanced, poorly-differentiated serous epithelial ovarian cancer treated with paclitaxel- plus platinum-based chemotherapy.The study was conducted on 46 patients who underwent surgery followed by paclitaxel- plus carboplatin-based chemotherapy. The tumor tissue samples were analyzed for p53 gene mutations. The median follow-up of survivors was 50.3 months.Twenty-three patients (50%) showed p53 mutations at exons 5 to 9. Sixteen (34.8%) patients had a polymorphism at codon 72 in exon 4 (SNP codon 72): 10 were Pro/Pro homozygous and 6 Pro/Arg heterozygous. Four polymorphic patients had a second mutation at exons 5 to 9. An inverse correlation was evidenced between the SNP codon 72 and mutations at exons 5 to 9, with the latter more frequently found in wild-type (Arg/Arg) codon 72 (19/30 versus 4/16, 63.3% versus 25.0%; p=0.03) cases. A clear trend for a higher response rate and longer progression-free and overall survival was observed in wild-type p53 and Pro/Pro polymorphic patients as compared to patients with mutant p53.The addition of paclitaxel to carboplatin does not appear to overcome the negative predictive and prognostic significance of p53 gene mutations in serous ovarian cancer. Nevertheless, the comprehensive analysis of p53 genotype, including the SNP codon 72, warrants further investigation in order to envisage individual responsiveness to cancer therapy." @default.
• W2131595296 created "2016-06-24" @default.
• W2131595296 creator A5002529270 @default.
• W2131595296 creator A5015450357 @default.
• W2131595296 creator A5017441193 @default.
• W2131595296 creator A5019570497 @default.
• W2131595296 creator A5039730681 @default.
• W2131595296 creator A5044979512 @default.
• W2131595296 creator A5045058166 @default.
• W2131595296 creator A5069459412 @default.
• W2131595296 creator A5069794903 @default.
• W2131595296 creator A5072913865 @default.
• W2131595296 date "2006-06-03" @default.
• W2131595296 modified "2023-09-23" @default.
• W2131595296 title "P53 gene status in patients with advanced serous epithelial ovarian cancer in relation to response to paclitaxel- plus platinum-based chemotherapy and long-term clinical outcome." @default.
• W2131595296 cites W107949984 @default.
• W2131595296 cites W1224191223 @default.
• W2131595296 cites W1519618894 @default.
• W2131595296 cites W1805678211 @default.
• W2131595296 cites W1809024175 @default.
• W2131595296 cites W185034008 @default.
• W2131595296 cites W1914367223 @default.
• W2131595296 cites W1942713680 @default.
• W2131595296 cites W1961928411 @default.
• W2131595296 cites W1966143946 @default.
• W2131595296 cites W1971274526 @default.
• W2131595296 cites W1983914017 @default.
• W2131595296 cites W1991191453 @default.
• W2131595296 cites W1998559412 @default.
• W2131595296 cites W1999555525 @default.
• W2131595296 cites W2002046262 @default.
• W2131595296 cites W2011498701 @default.
• W2131595296 cites W2035464989 @default.
• W2131595296 cites W2038334562 @default.
• W2131595296 cites W2039832404 @default.
• W2131595296 cites W2048237670 @default.
• W2131595296 cites W2060208117 @default.
• W2131595296 cites W2073690276 @default.
• W2131595296 cites W2082547329 @default.
• W2131595296 cites W2085731614 @default.
• W2131595296 cites W2088344791 @default.
• W2131595296 cites W2094789754 @default.
• W2131595296 cites W2097105130 @default.
• W2131595296 cites W2105616976 @default.
• W2131595296 cites W2108272979 @default.
• W2131595296 cites W2109424050 @default.
• W2131595296 cites W2111803165 @default.
• W2131595296 cites W2126787895 @default.
• W2131595296 cites W2130941707 @default.
• W2131595296 cites W2132979902 @default.
• W2131595296 cites W2143219457 @default.
• W2131595296 cites W2148522609 @default.
• W2131595296 cites W2160516296 @default.
• W2131595296 cites W2280778178 @default.
• W2131595296 cites W2440323592 @default.
• W2131595296 cites W6320432 @default.
• W2131595296 cites W75975850 @default.
• W2131595296 cites W77477776 @default.
• W2131595296 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16739339" @default.
• W2131595296 hasPublicationYear "2006" @default.
• W2131595296 type Work @default.
• W2131595296 sameAs 2131595296 @default.
• W2131595296 citedByCount "23" @default.
• W2131595296 countsByYear W21315952962012 @default.
• W2131595296 countsByYear W21315952962014 @default.
• W2131595296 countsByYear W21315952962015 @default.
• W2131595296 countsByYear W21315952962016 @default.
• W2131595296 countsByYear W21315952962017 @default.
• W2131595296 countsByYear W21315952962018 @default.
• W2131595296 countsByYear W21315952962022 @default.
• W2131595296 crossrefType "journal-article" @default.
• W2131595296 hasAuthorship W2131595296A5002529270 @default.
• W2131595296 hasAuthorship W2131595296A5015450357 @default.
• W2131595296 hasAuthorship W2131595296A5017441193 @default.
• W2131595296 hasAuthorship W2131595296A5019570497 @default.
• W2131595296 hasAuthorship W2131595296A5039730681 @default.
• W2131595296 hasAuthorship W2131595296A5044979512 @default.
• W2131595296 hasAuthorship W2131595296A5045058166 @default.
• W2131595296 hasAuthorship W2131595296A5069459412 @default.
• W2131595296 hasAuthorship W2131595296A5069794903 @default.
• W2131595296 hasAuthorship W2131595296A5072913865 @default.
• W2131595296 hasConcept C104317684 @default.
• W2131595296 hasConcept C121608353 @default.
• W2131595296 hasConcept C126322002 @default.
• W2131595296 hasConcept C135763542 @default.
• W2131595296 hasConcept C139275648 @default.
• W2131595296 hasConcept C143998085 @default.
• W2131595296 hasConcept C150173356 @default.
• W2131595296 hasConcept C153209595 @default.
• W2131595296 hasConcept C2776694085 @default.
• W2131595296 hasConcept C2777292972 @default.
• W2131595296 hasConcept C2778239845 @default.
• W2131595296 hasConcept C2780427987 @default.
• W2131595296 hasConcept C2781451048 @default.
• W2131595296 hasConcept C36823959 @default.
• W2131595296 hasConcept C502942594 @default.
• W2131595296 hasConcept C54355233 @default.
• W2131595296 hasConcept C71924100 @default.

• next