Matches in SemOpenAlex for { <https://semopenalex.org/work/W2131613065> ?p ?o ?g. }
- W2131613065 endingPage "927" @default.
- W2131613065 startingPage "918" @default.
- W2131613065 abstract "ABSTRACT. Megalin is the most abundant endocytic receptor in the proximal tubule epithelium (PTE), where it is concentrated in clathrin-coated pits (CCPs) and vesicles in the brush border region. The heterotrimeric G protein alpha subunit, Gαi3, has also been localized to the brush border region of PTE. By immunofluorescence GIPC and GAIP, components of G protein-mediated signaling pathways, are also concentrated in the brush border region of PTE and are present in megalin-expressing cell lines. By cell fractionation, these signaling molecules cosediment with megalin in brush border and microvillar fractions. GAIP is found by immunoelectron microscopy in CCPs, and GIPC is found in CCPs and apical tubules of endocytic compartments in the renal brush border. In precipitation assays, GST-GIPC specifically binds megalin. The concentration of Gαi3, GIPC, and GAIP with megalin in endocytic compartments of the proximal tubule, where extensive endocytosis occurs, and the interaction between GIPC and the cytoplasmic tail of megalin suggest a model whereby G protein-mediated signaling may regulate megalin’s endocytic function and/or trafficking." @default.
- W2131613065 created "2016-06-24" @default.
- W2131613065 creator A5038389980 @default.
- W2131613065 creator A5041144191 @default.
- W2131613065 creator A5049439690 @default.
- W2131613065 creator A5070192240 @default.
- W2131613065 date "2002-04-01" @default.
- W2131613065 modified "2023-10-18" @default.
- W2131613065 title "GAIP, GIPC and Gαi3 are Concentrated in Endocytic Compartments of Proximal Tubule Cells" @default.
- W2131613065 cites W1492722920 @default.
- W2131613065 cites W1537485370 @default.
- W2131613065 cites W1574984301 @default.
- W2131613065 cites W1578786377 @default.
- W2131613065 cites W1805987438 @default.
- W2131613065 cites W1936416558 @default.
- W2131613065 cites W1968646220 @default.
- W2131613065 cites W1976941367 @default.
- W2131613065 cites W1983884349 @default.
- W2131613065 cites W1991418321 @default.
- W2131613065 cites W1995084774 @default.
- W2131613065 cites W1998197394 @default.
- W2131613065 cites W2006300948 @default.
- W2131613065 cites W2018833058 @default.
- W2131613065 cites W2022100656 @default.
- W2131613065 cites W2025929812 @default.
- W2131613065 cites W2025973335 @default.
- W2131613065 cites W2028927099 @default.
- W2131613065 cites W2034939472 @default.
- W2131613065 cites W2037805609 @default.
- W2131613065 cites W2045488232 @default.
- W2131613065 cites W2051811723 @default.
- W2131613065 cites W2054386830 @default.
- W2131613065 cites W2056038118 @default.
- W2131613065 cites W2060650825 @default.
- W2131613065 cites W2061380588 @default.
- W2131613065 cites W2072893670 @default.
- W2131613065 cites W2075139124 @default.
- W2131613065 cites W2103686156 @default.
- W2131613065 cites W2103858107 @default.
- W2131613065 cites W2110869010 @default.
- W2131613065 cites W2114748778 @default.
- W2131613065 cites W2119889843 @default.
- W2131613065 cites W2120257112 @default.
- W2131613065 cites W2124211877 @default.
- W2131613065 cites W2124829726 @default.
- W2131613065 cites W2128556903 @default.
- W2131613065 cites W2133709938 @default.
- W2131613065 cites W2134326270 @default.
- W2131613065 cites W2140909611 @default.
- W2131613065 cites W2141356089 @default.
- W2131613065 cites W2145479098 @default.
- W2131613065 cites W2154429701 @default.
- W2131613065 cites W2161824703 @default.
- W2131613065 cites W2162480928 @default.
- W2131613065 cites W2166170924 @default.
- W2131613065 cites W2168535042 @default.
- W2131613065 cites W2170755436 @default.
- W2131613065 cites W2189210884 @default.
- W2131613065 cites W2208575070 @default.
- W2131613065 cites W2303879656 @default.
- W2131613065 doi "https://doi.org/10.1681/asn.v134918" @default.
- W2131613065 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11912251" @default.
- W2131613065 hasPublicationYear "2002" @default.
- W2131613065 type Work @default.
- W2131613065 sameAs 2131613065 @default.
- W2131613065 citedByCount "72" @default.
- W2131613065 countsByYear W21316130652012 @default.
- W2131613065 countsByYear W21316130652013 @default.
- W2131613065 countsByYear W21316130652014 @default.
- W2131613065 countsByYear W21316130652016 @default.
- W2131613065 countsByYear W21316130652017 @default.
- W2131613065 countsByYear W21316130652020 @default.
- W2131613065 countsByYear W21316130652022 @default.
- W2131613065 countsByYear W21316130652023 @default.
- W2131613065 crossrefType "journal-article" @default.
- W2131613065 hasAuthorship W2131613065A5038389980 @default.
- W2131613065 hasAuthorship W2131613065A5041144191 @default.
- W2131613065 hasAuthorship W2131613065A5049439690 @default.
- W2131613065 hasAuthorship W2131613065A5070192240 @default.
- W2131613065 hasBestOaLocation W21316130651 @default.
- W2131613065 hasConcept C102747710 @default.
- W2131613065 hasConcept C130316041 @default.
- W2131613065 hasConcept C170493617 @default.
- W2131613065 hasConcept C185592680 @default.
- W2131613065 hasConcept C190062978 @default.
- W2131613065 hasConcept C203014093 @default.
- W2131613065 hasConcept C204232928 @default.
- W2131613065 hasConcept C28005876 @default.
- W2131613065 hasConcept C2993140218 @default.
- W2131613065 hasConcept C41625074 @default.
- W2131613065 hasConcept C5426402 @default.
- W2131613065 hasConcept C55493867 @default.
- W2131613065 hasConcept C79747257 @default.
- W2131613065 hasConcept C86803240 @default.
- W2131613065 hasConcept C95444343 @default.
- W2131613065 hasConceptScore W2131613065C102747710 @default.
- W2131613065 hasConceptScore W2131613065C130316041 @default.
- W2131613065 hasConceptScore W2131613065C170493617 @default.