FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2131637158> ?p ?o ?g. }

• W2131637158 endingPage "515" @default.
• W2131637158 startingPage "502" @default.
• W2131637158 abstract "The liver is the major source of proteins used throughout the body for various functions. Upon injury or infection, an acute phase response (APR) is initiated in the liver that is primarily mediated by inflammatory cytokines such as interleukin-1beta (IL-1beta) and interleukin-6. Among others, the APR is characterized by an altered protein synthetic profile. We used two-dimensional gel electrophoresis to study the dynamics of changes in protein synthesis in hepatocytes exposed to these inflammatory cytokines. Protein profiles were quantified using image analysis and further analyzed using multivariate statistical methods. Our results indicate that IL-1beta and IL-6 each induces secreted protein responses with distinct dynamics and dose-dependence. Parallel stimulation by IL-1beta and IL-6 results in a protein pattern indistinguishable from the IL-1beta pattern, indicating a dominant effect of IL-1beta over IL-6 at the doses tested. Multidimensional scaling (MDS) of correlation distances between protein secretion levels revealed two protein pairs that are robustly co-secreted across the various cytokine stimulation conditions, suggesting shared regulatory pathways. Finally, we also used multivariate alternating conditional expectation (MACE) to identify transformation functions that discriminated the cytokine-stimulated and untreated hepatocyte-secreted protein profiles. Our analysis indicates that the expression of neutrophil gelatinase-associated lipocalin (NGAL) was sufficient to discriminate between IL-1beta and IL-6 stimulation. The combination of proteomics and multivariate analysis is expected to provide new information on the cellular regulatory networks involved in generating specific cellular responses." @default.
• W2131637158 created "2016-06-24" @default.
• W2131637158 creator A5006533104 @default.
• W2131637158 creator A5008616093 @default.
• W2131637158 creator A5012474973 @default.
• W2131637158 creator A5055658784 @default.
• W2131637158 creator A5059731538 @default.
• W2131637158 creator A5080653951 @default.
• W2131637158 creator A5087420269 @default.
• W2131637158 date "2005-05-25" @default.
• W2131637158 modified "2023-10-09" @default.
• W2131637158 title "Identification of neutrophil gelatinase-associated lipocalin (NGAL) as a discriminatory marker of the hepatocyte-secreted protein response to IL-1β: a proteomic analysis" @default.
• W2131637158 cites W1515927821 @default.
• W2131637158 cites W1532411911 @default.
• W2131637158 cites W1651049521 @default.
• W2131637158 cites W1931740302 @default.
• W2131637158 cites W1966507802 @default.
• W2131637158 cites W1970197409 @default.
• W2131637158 cites W1977178283 @default.
• W2131637158 cites W1977807583 @default.
• W2131637158 cites W1977950302 @default.
• W2131637158 cites W1982691186 @default.
• W2131637158 cites W1982926066 @default.
• W2131637158 cites W1985404428 @default.
• W2131637158 cites W1992148573 @default.
• W2131637158 cites W1993364719 @default.
• W2131637158 cites W2004907641 @default.
• W2131637158 cites W2011151971 @default.
• W2131637158 cites W2012667119 @default.
• W2131637158 cites W2016492637 @default.
• W2131637158 cites W2018415739 @default.
• W2131637158 cites W2027167256 @default.
• W2131637158 cites W2028132637 @default.
• W2131637158 cites W2028705304 @default.
• W2131637158 cites W2030748132 @default.
• W2131637158 cites W2034105313 @default.
• W2131637158 cites W2036031516 @default.
• W2131637158 cites W2037616254 @default.
• W2131637158 cites W2040970267 @default.
• W2131637158 cites W2055384635 @default.
• W2131637158 cites W2062652813 @default.
• W2131637158 cites W2063297894 @default.
• W2131637158 cites W2065326187 @default.
• W2131637158 cites W2066978845 @default.
• W2131637158 cites W2069869233 @default.
• W2131637158 cites W2075983808 @default.
• W2131637158 cites W2085173280 @default.
• W2131637158 cites W2087196505 @default.
• W2131637158 cites W2125796919 @default.
• W2131637158 cites W2145829330 @default.
• W2131637158 cites W2151564624 @default.
• W2131637158 cites W2152825437 @default.
• W2131637158 cites W2154746915 @default.
• W2131637158 cites W2154786756 @default.
• W2131637158 cites W2155376155 @default.
• W2131637158 cites W2162428378 @default.
• W2131637158 cites W2164452325 @default.
• W2131637158 cites W2168778865 @default.
• W2131637158 cites W2168935435 @default.
• W2131637158 cites W2170257664 @default.
• W2131637158 cites W2317184793 @default.
• W2131637158 cites W4234616979 @default.
• W2131637158 cites W4244969167 @default.
• W2131637158 doi "https://doi.org/10.1002/bit.20535" @default.
• W2131637158 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15918168" @default.
• W2131637158 hasPublicationYear "2005" @default.
• W2131637158 type Work @default.
• W2131637158 sameAs 2131637158 @default.
• W2131637158 citedByCount "62" @default.
• W2131637158 countsByYear W21316371582012 @default.
• W2131637158 countsByYear W21316371582013 @default.
• W2131637158 countsByYear W21316371582014 @default.
• W2131637158 countsByYear W21316371582015 @default.
• W2131637158 countsByYear W21316371582016 @default.
• W2131637158 countsByYear W21316371582017 @default.
• W2131637158 countsByYear W21316371582018 @default.
• W2131637158 countsByYear W21316371582019 @default.
• W2131637158 countsByYear W21316371582020 @default.
• W2131637158 countsByYear W21316371582021 @default.
• W2131637158 countsByYear W21316371582022 @default.
• W2131637158 countsByYear W21316371582023 @default.
• W2131637158 crossrefType "journal-article" @default.
• W2131637158 hasAuthorship W2131637158A5006533104 @default.
• W2131637158 hasAuthorship W2131637158A5008616093 @default.
• W2131637158 hasAuthorship W2131637158A5012474973 @default.
• W2131637158 hasAuthorship W2131637158A5055658784 @default.
• W2131637158 hasAuthorship W2131637158A5059731538 @default.
• W2131637158 hasAuthorship W2131637158A5080653951 @default.
• W2131637158 hasAuthorship W2131637158A5087420269 @default.
• W2131637158 hasConcept C104317684 @default.
• W2131637158 hasConcept C134018914 @default.
• W2131637158 hasConcept C156399914 @default.
• W2131637158 hasConcept C202751555 @default.
• W2131637158 hasConcept C20299238 @default.
• W2131637158 hasConcept C203014093 @default.
• W2131637158 hasConcept C24998067 @default.
• W2131637158 hasConcept C2776200302 @default.
• W2131637158 hasConcept C2776914184 @default.

• next