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• W2131645183 abstract "The inherent modularity of polypeptides, oligonucleotides and oligosaccharides has been harnessed to achieve generalized synthesis platforms. Importantly, like these other targets, most small-molecule natural products are biosynthesized via iterative coupling of bifunctional building blocks. This suggests that many small molecules also possess inherent modularity commensurate with systematic building block-based construction. Supporting this hypothesis, here we report that the polyene motifs found in >75% of all known polyene natural products can be synthesized using just 12 building blocks and one coupling reaction. Using the same general retrosynthetic algorithm and reaction conditions, this platform enabled both the synthesis of a wide range of polyene frameworks that covered all of this natural-product chemical space and the first total syntheses of the polyene natural products asnipyrone B, physarigin A and neurosporaxanthin b-D-glucopyranoside. Collectively, these results suggest the potential for a more generalized approach to making small molecules in the laboratory." @default.
• W2131645183 created "2016-06-24" @default.
• W2131645183 creator A5037149163 @default.
• W2131645183 creator A5040723642 @default.
• W2131645183 creator A5067967131 @default.
• W2131645183 date "2014-05-11" @default.
• W2131645183 modified "2023-10-02" @default.
• W2131645183 title "Synthesis of most polyene natural product motifs using just 12 building blocks and one coupling reaction" @default.
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• W2131645183 doi "https://doi.org/10.1038/nchem.1947" @default.
• W2131645183 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4079739" @default.
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• W2131645183 hasPublicationYear "2014" @default.
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