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• W2131667991 abstract "The noninvasive delivery of insulin continues to be a major goal for the treatment of diabetes mellitus. Oral–enteric administration would make insulin delivery easier and more effective, as higher patient compliance and improved glycemic control are likely; yet the oral–enteric pathway has been unfeasible owing to insulin's susceptibility to proteolytic degradation and inefficient enteric uptake. Herein we show that a noninvasive oral delivery route for insulin is possible through the vitamin B12 uptake pathway. In diabetic rat models, insulin–B12 conjugates can significantly lower blood glucose levels when administered orally." @default.
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• W2131667991 date "2007-11-29" @default.
• W2131667991 modified "2023-10-14" @default.
• W2131667991 title "Vitamin B12 as a Carrier for the Oral Delivery of Insulin" @default.
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• W2131667991 doi "https://doi.org/10.1002/cmdc.200700239" @default.
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