Matches in SemOpenAlex for { <https://semopenalex.org/work/W2131715664> ?p ?o ?g. }
- W2131715664 endingPage "831" @default.
- W2131715664 startingPage "823" @default.
- W2131715664 abstract "Triple-negative breast cancer (TNBC) is a heterogeneous disease. Possibly genetic characterisation provides the most appropriate information on tumour biology and prognosis, but it is only limitedly available in clinical practice. The aim of this investigation was to explore what additional prognostic information could be gained from detailed histomorphologic report. Patients and method: patients were selected retrospectively operated from 2005 to 2009 in one institution and charts were revised. Beyond age, tumour and nodal status, histologic grade and therapy, the additional pathologic characteristics were also involved in analysis: necrosis, lymphocytic infiltration, peritumoural vascular invasion (PVI), perineural invasion, DCIS extent and grade, perinodal spread, mitotic activity index (MAI). Results: 295 early TNBC were involved. In univariate survival analysis with a mean follow-up of 3.57 years the tumour size, the nodal status, type of operation (conservation or mastectomy), irradiation, PVI and perinodal spread proved to be significantly connected with both disease free survival (DFS) and breast cancer specific overall survival (BSOS), and necrosis and chemotherapy with BSOS. Necrosis analysed together with lymphocytic infiltrate showed greater predicting power. In multivariate analysis nodal metastasis, necrosis positive/lymphacytic infiltration negative status and lack of irradiation has significant negative impact on DFS (p = <0.0001 HR:1.98 [1.4–2.77], p = <0.017 HR:2.1 [1.1–3.8], p = <0.001 HR:0.25 [0.11–0.57], respectively) and BSOS (p = <0.0001 HR:2.47 [1.8–3.4], p = <0.017 HR:3.7 [1.6–8.2], p = <0.0017 HR:0.24 [0.1–0.58], respectively). For DFS perivascular invasion also showed significant effect (p = <0.042 HR:2.5 [1.0–6.0]). Nodal status was the strongest prognostic parameter but other histomorphologic parameters can be used for prognosis prediction." @default.
- W2131715664 created "2016-06-24" @default.
- W2131715664 creator A5016824553 @default.
- W2131715664 creator A5023069455 @default.
- W2131715664 creator A5036586659 @default.
- W2131715664 creator A5042046866 @default.
- W2131715664 creator A5079291878 @default.
- W2131715664 date "2012-03-14" @default.
- W2131715664 modified "2023-10-16" @default.
- W2131715664 title "Significance of Histomorphology of Early Triple-Negative Breast Cancer" @default.
- W2131715664 cites W1981105725 @default.
- W2131715664 cites W1981741001 @default.
- W2131715664 cites W1986657548 @default.
- W2131715664 cites W1989663680 @default.
- W2131715664 cites W1992261227 @default.
- W2131715664 cites W1995224853 @default.
- W2131715664 cites W2019727602 @default.
- W2131715664 cites W2033616612 @default.
- W2131715664 cites W2040872996 @default.
- W2131715664 cites W2041497771 @default.
- W2131715664 cites W2050991579 @default.
- W2131715664 cites W2054270840 @default.
- W2131715664 cites W2070263688 @default.
- W2131715664 cites W2077850208 @default.
- W2131715664 cites W2104638648 @default.
- W2131715664 cites W2112132750 @default.
- W2131715664 cites W2118697447 @default.
- W2131715664 cites W2125819720 @default.
- W2131715664 cites W2126730454 @default.
- W2131715664 cites W2130900820 @default.
- W2131715664 cites W2131964282 @default.
- W2131715664 cites W2131994307 @default.
- W2131715664 cites W2134539328 @default.
- W2131715664 cites W2135736714 @default.
- W2131715664 cites W2135936056 @default.
- W2131715664 cites W2137853125 @default.
- W2131715664 cites W2141572172 @default.
- W2131715664 cites W2142179227 @default.
- W2131715664 cites W2151835067 @default.
- W2131715664 cites W2158997529 @default.
- W2131715664 cites W2161426850 @default.
- W2131715664 doi "https://doi.org/10.1007/s12253-012-9510-3" @default.
- W2131715664 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22415664" @default.
- W2131715664 hasPublicationYear "2012" @default.
- W2131715664 type Work @default.
- W2131715664 sameAs 2131715664 @default.
- W2131715664 citedByCount "3" @default.
- W2131715664 countsByYear W21317156642016 @default.
- W2131715664 countsByYear W21317156642020 @default.
- W2131715664 crossrefType "journal-article" @default.
- W2131715664 hasAuthorship W2131715664A5016824553 @default.
- W2131715664 hasAuthorship W2131715664A5023069455 @default.
- W2131715664 hasAuthorship W2131715664A5036586659 @default.
- W2131715664 hasAuthorship W2131715664A5042046866 @default.
- W2131715664 hasAuthorship W2131715664A5079291878 @default.
- W2131715664 hasConcept C121332964 @default.
- W2131715664 hasConcept C121608353 @default.
- W2131715664 hasConcept C126322002 @default.
- W2131715664 hasConcept C142724271 @default.
- W2131715664 hasConcept C143998085 @default.
- W2131715664 hasConcept C144301174 @default.
- W2131715664 hasConcept C153400128 @default.
- W2131715664 hasConcept C2776694085 @default.
- W2131715664 hasConcept C2777154038 @default.
- W2131715664 hasConcept C2780110267 @default.
- W2131715664 hasConcept C38180746 @default.
- W2131715664 hasConcept C503630168 @default.
- W2131715664 hasConcept C509974204 @default.
- W2131715664 hasConcept C530470458 @default.
- W2131715664 hasConcept C71924100 @default.
- W2131715664 hasConcept C97355855 @default.
- W2131715664 hasConceptScore W2131715664C121332964 @default.
- W2131715664 hasConceptScore W2131715664C121608353 @default.
- W2131715664 hasConceptScore W2131715664C126322002 @default.
- W2131715664 hasConceptScore W2131715664C142724271 @default.
- W2131715664 hasConceptScore W2131715664C143998085 @default.
- W2131715664 hasConceptScore W2131715664C144301174 @default.
- W2131715664 hasConceptScore W2131715664C153400128 @default.
- W2131715664 hasConceptScore W2131715664C2776694085 @default.
- W2131715664 hasConceptScore W2131715664C2777154038 @default.
- W2131715664 hasConceptScore W2131715664C2780110267 @default.
- W2131715664 hasConceptScore W2131715664C38180746 @default.
- W2131715664 hasConceptScore W2131715664C503630168 @default.
- W2131715664 hasConceptScore W2131715664C509974204 @default.
- W2131715664 hasConceptScore W2131715664C530470458 @default.
- W2131715664 hasConceptScore W2131715664C71924100 @default.
- W2131715664 hasConceptScore W2131715664C97355855 @default.
- W2131715664 hasIssue "4" @default.
- W2131715664 hasLocation W21317156641 @default.
- W2131715664 hasLocation W21317156642 @default.
- W2131715664 hasOpenAccess W2131715664 @default.
- W2131715664 hasPrimaryLocation W21317156641 @default.
- W2131715664 hasRelatedWork W1905605175 @default.
- W2131715664 hasRelatedWork W1975479077 @default.
- W2131715664 hasRelatedWork W1988030834 @default.
- W2131715664 hasRelatedWork W2048873934 @default.
- W2131715664 hasRelatedWork W2234839489 @default.
- W2131715664 hasRelatedWork W2361700749 @default.