Matches in SemOpenAlex for { <https://semopenalex.org/work/W2131717611> ?p ?o ?g. }
- W2131717611 endingPage "1332" @default.
- W2131717611 startingPage "1324" @default.
- W2131717611 abstract "The factors that determine whether a breast carcinoma will develop into inflammatory breast cancer (IBC) remain poorly understood. Recent evidence indicates that the tumor stroma influences cancer phenotypes. We tested the hypotheses that the gene expression signature of the tumor stroma is a distinctive feature of IBC. We used laser capture microdissection to obtain enriched populations of tumor epithelial cells and adjacent stromal cells from 15 patients with IBC and 35 patients with invasive, noninflammatory breast cancer (non-IBC). Their mRNA expression profiles were assessed using Affymetrix GeneChips. In addition, a previously established classifier for IBC was evaluated for the resulting data sets. The gene expression profile of the tumor stroma distinguished IBC from non-IBC, and a previously established IBC prediction signature performed better in classifying IBC using the gene expression profile of the tumor stroma than it did using the profile of the tumor epithelium. In a pathway analysis, the genes differentially expressed between IBC and non-IBC tumors clustered in distinct pathways. We identified multiple pathways related to the endoplasmic stress response that could be functionally significant in IBC. Our findings suggest that the gene expression in the tumor stroma may play a role in determining the IBC phenotype." @default.
- W2131717611 created "2016-06-24" @default.
- W2131717611 creator A5001770642 @default.
- W2131717611 creator A5032870776 @default.
- W2131717611 creator A5052780898 @default.
- W2131717611 creator A5053260313 @default.
- W2131717611 creator A5060450409 @default.
- W2131717611 creator A5062387652 @default.
- W2131717611 creator A5063851986 @default.
- W2131717611 creator A5065709859 @default.
- W2131717611 creator A5073284312 @default.
- W2131717611 creator A5077852553 @default.
- W2131717611 date "2007-11-12" @default.
- W2131717611 modified "2023-10-16" @default.
- W2131717611 title "A stromal gene signature associated with inflammatory breast cancer" @default.
- W2131717611 cites W1796586970 @default.
- W2131717611 cites W1862973715 @default.
- W2131717611 cites W1965037168 @default.
- W2131717611 cites W1967215636 @default.
- W2131717611 cites W1979324666 @default.
- W2131717611 cites W1980188722 @default.
- W2131717611 cites W1987358143 @default.
- W2131717611 cites W1992608045 @default.
- W2131717611 cites W1997569631 @default.
- W2131717611 cites W1999463736 @default.
- W2131717611 cites W1999509975 @default.
- W2131717611 cites W2008292129 @default.
- W2131717611 cites W2015565459 @default.
- W2131717611 cites W2023659903 @default.
- W2131717611 cites W2029413197 @default.
- W2131717611 cites W2052599502 @default.
- W2131717611 cites W2063765857 @default.
- W2131717611 cites W2070477528 @default.
- W2131717611 cites W2087739228 @default.
- W2131717611 cites W2095180889 @default.
- W2131717611 cites W2096694106 @default.
- W2131717611 cites W2097255042 @default.
- W2131717611 cites W2097699549 @default.
- W2131717611 cites W2101037339 @default.
- W2131717611 cites W2102785309 @default.
- W2131717611 cites W2103543394 @default.
- W2131717611 cites W2104975229 @default.
- W2131717611 cites W2109781138 @default.
- W2131717611 cites W2114808102 @default.
- W2131717611 cites W2115343453 @default.
- W2131717611 cites W2122673439 @default.
- W2131717611 cites W2128985829 @default.
- W2131717611 cites W2130690901 @default.
- W2131717611 cites W2131994307 @default.
- W2131717611 cites W2135994545 @default.
- W2131717611 cites W2138550913 @default.
- W2131717611 cites W2156711378 @default.
- W2131717611 cites W2156894263 @default.
- W2131717611 cites W2157840751 @default.
- W2131717611 cites W2158118614 @default.
- W2131717611 cites W2160450758 @default.
- W2131717611 cites W2162437451 @default.
- W2131717611 cites W2169569769 @default.
- W2131717611 cites W2171137965 @default.
- W2131717611 cites W4294107304 @default.
- W2131717611 cites W4323874309 @default.
- W2131717611 doi "https://doi.org/10.1002/ijc.23237" @default.
- W2131717611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17999412" @default.
- W2131717611 hasPublicationYear "2007" @default.
- W2131717611 type Work @default.
- W2131717611 sameAs 2131717611 @default.
- W2131717611 citedByCount "148" @default.
- W2131717611 countsByYear W21317176112012 @default.
- W2131717611 countsByYear W21317176112013 @default.
- W2131717611 countsByYear W21317176112014 @default.
- W2131717611 countsByYear W21317176112015 @default.
- W2131717611 countsByYear W21317176112016 @default.
- W2131717611 countsByYear W21317176112017 @default.
- W2131717611 countsByYear W21317176112018 @default.
- W2131717611 countsByYear W21317176112019 @default.
- W2131717611 countsByYear W21317176112020 @default.
- W2131717611 countsByYear W21317176112021 @default.
- W2131717611 countsByYear W21317176112022 @default.
- W2131717611 countsByYear W21317176112023 @default.
- W2131717611 crossrefType "journal-article" @default.
- W2131717611 hasAuthorship W2131717611A5001770642 @default.
- W2131717611 hasAuthorship W2131717611A5032870776 @default.
- W2131717611 hasAuthorship W2131717611A5052780898 @default.
- W2131717611 hasAuthorship W2131717611A5053260313 @default.
- W2131717611 hasAuthorship W2131717611A5060450409 @default.
- W2131717611 hasAuthorship W2131717611A5062387652 @default.
- W2131717611 hasAuthorship W2131717611A5063851986 @default.
- W2131717611 hasAuthorship W2131717611A5065709859 @default.
- W2131717611 hasAuthorship W2131717611A5073284312 @default.
- W2131717611 hasAuthorship W2131717611A5077852553 @default.
- W2131717611 hasConcept C104317684 @default.
- W2131717611 hasConcept C11242284 @default.
- W2131717611 hasConcept C121608353 @default.
- W2131717611 hasConcept C125965507 @default.
- W2131717611 hasConcept C127716648 @default.
- W2131717611 hasConcept C142724271 @default.
- W2131717611 hasConcept C150194340 @default.
- W2131717611 hasConcept C16930146 @default.