FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2131723654> ?p ?o ?g. }

• W2131723654 endingPage "493" @default.
• W2131723654 startingPage "488" @default.
• W2131723654 abstract "In intravesical Bacille bilié de Calmette-Guérin (BCG) immunotherapy of superficial bladder cancer, a T cell mediated immunological reaction is associated with the antitumor activity. To gain insight into the approximate number of BCG bacteria retained in the normal, noninjured, urinary bladder after intravesical application responsible for induction of the immune reaction, the utility of a sensitive polymerase chain reaction (PCR) based assay was investigated in a guinea pig model.After one single or six subsequent weekly instillations with 1x10(7) CFU of BCG, the bladders were resected and processed for BCG determination with PCR. The bladders were resected 24 h after instillation, aiming at (semi)quantifying the number of BCG organisms able to resist the natural voiding washout of the bladder. The PCR was based on amplification of a 249 base pair fragment of the insertion element IS6110 and is specific for bacteria belonging to the Mycobacterium tuberculosis complex which includes Mycobacterium bovis BCG.After one single instillation no detectable BCG retention was found. However, after six weekly instillations, BCG bacteria could be demonstrated in 2 out of 5 guinea pig bladders, indicating that the number of adhering BCG organisms was around the detection limit of the assay (600-1,000 BCG bacteria per bladder).The data suggest that after six instillations, the retention of BCG in the guinea pig bladder is enhanced as compared with one single instillation. This finding is suggestive of a role of the inflammatory process that is, besides immune system mediated reactions, associated with intravesical BCG instillations. The nature of the molecules involved in enhanced BCG retention after repeated instillations remains to be investigated." @default.
• W2131723654 created "2016-06-24" @default.
• W2131723654 creator A5009626204 @default.
• W2131723654 creator A5018057184 @default.
• W2131723654 creator A5054637506 @default.
• W2131723654 creator A5056368855 @default.
• W2131723654 creator A5074829451 @default.
• W2131723654 creator A5087635719 @default.
• W2131723654 date "2000-01-01" @default.
• W2131723654 modified "2023-09-27" @default.
• W2131723654 title "Polymerase Chain Reaction Based Method for the Detection of BCG Retention after Intravesical Instillation in Guinea Pig Bladders" @default.
• W2131723654 cites W1620843454 @default.
• W2131723654 cites W176965263 @default.
• W2131723654 cites W1881197443 @default.
• W2131723654 cites W19688913 @default.
• W2131723654 cites W1969800450 @default.
• W2131723654 cites W1973056383 @default.
• W2131723654 cites W1976045232 @default.
• W2131723654 cites W1998926208 @default.
• W2131723654 cites W2016971744 @default.
• W2131723654 cites W2019492645 @default.
• W2131723654 cites W2050590796 @default.
• W2131723654 cites W2147817958 @default.
• W2131723654 cites W2151951132 @default.
• W2131723654 cites W2161869216 @default.
• W2131723654 cites W2166229810 @default.
• W2131723654 cites W2166243539 @default.
• W2131723654 cites W2394883645 @default.
• W2131723654 cites W2395489654 @default.
• W2131723654 cites W2409029005 @default.
• W2131723654 cites W2410681755 @default.
• W2131723654 cites W2412281282 @default.
• W2131723654 cites W2412549489 @default.
• W2131723654 cites W2415526431 @default.
• W2131723654 cites W2460892140 @default.
• W2131723654 cites W2911567891 @default.
• W2131723654 doi "https://doi.org/10.1159/000020173" @default.
• W2131723654 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10765082" @default.
• W2131723654 hasPublicationYear "2000" @default.
• W2131723654 type Work @default.
• W2131723654 sameAs 2131723654 @default.
• W2131723654 citedByCount "1" @default.
• W2131723654 crossrefType "journal-article" @default.
• W2131723654 hasAuthorship W2131723654A5009626204 @default.
• W2131723654 hasAuthorship W2131723654A5018057184 @default.
• W2131723654 hasAuthorship W2131723654A5054637506 @default.
• W2131723654 hasAuthorship W2131723654A5056368855 @default.
• W2131723654 hasAuthorship W2131723654A5074829451 @default.
• W2131723654 hasAuthorship W2131723654A5087635719 @default.
• W2131723654 hasConcept C104317684 @default.
• W2131723654 hasConcept C121608353 @default.
• W2131723654 hasConcept C126322002 @default.
• W2131723654 hasConcept C126894567 @default.
• W2131723654 hasConcept C142724271 @default.
• W2131723654 hasConcept C203014093 @default.
• W2131723654 hasConcept C2777701055 @default.
• W2131723654 hasConcept C2777975735 @default.
• W2131723654 hasConcept C2778288313 @default.
• W2131723654 hasConcept C2778497218 @default.
• W2131723654 hasConcept C2778815084 @default.
• W2131723654 hasConcept C2779762690 @default.
• W2131723654 hasConcept C2780352672 @default.
• W2131723654 hasConcept C2781069245 @default.
• W2131723654 hasConcept C49105822 @default.
• W2131723654 hasConcept C523546767 @default.
• W2131723654 hasConcept C54355233 @default.
• W2131723654 hasConcept C55493867 @default.
• W2131723654 hasConcept C71924100 @default.
• W2131723654 hasConcept C86803240 @default.
• W2131723654 hasConcept C8891405 @default.
• W2131723654 hasConcept C89423630 @default.
• W2131723654 hasConceptScore W2131723654C104317684 @default.
• W2131723654 hasConceptScore W2131723654C121608353 @default.
• W2131723654 hasConceptScore W2131723654C126322002 @default.
• W2131723654 hasConceptScore W2131723654C126894567 @default.
• W2131723654 hasConceptScore W2131723654C142724271 @default.
• W2131723654 hasConceptScore W2131723654C203014093 @default.
• W2131723654 hasConceptScore W2131723654C2777701055 @default.
• W2131723654 hasConceptScore W2131723654C2777975735 @default.
• W2131723654 hasConceptScore W2131723654C2778288313 @default.
• W2131723654 hasConceptScore W2131723654C2778497218 @default.
• W2131723654 hasConceptScore W2131723654C2778815084 @default.
• W2131723654 hasConceptScore W2131723654C2779762690 @default.
• W2131723654 hasConceptScore W2131723654C2780352672 @default.
• W2131723654 hasConceptScore W2131723654C2781069245 @default.
• W2131723654 hasConceptScore W2131723654C49105822 @default.
• W2131723654 hasConceptScore W2131723654C523546767 @default.
• W2131723654 hasConceptScore W2131723654C54355233 @default.
• W2131723654 hasConceptScore W2131723654C55493867 @default.
• W2131723654 hasConceptScore W2131723654C71924100 @default.
• W2131723654 hasConceptScore W2131723654C86803240 @default.
• W2131723654 hasConceptScore W2131723654C8891405 @default.
• W2131723654 hasConceptScore W2131723654C89423630 @default.
• W2131723654 hasIssue "4" @default.
• W2131723654 hasLocation W21317236541 @default.
• W2131723654 hasLocation W21317236542 @default.
• W2131723654 hasOpenAccess W2131723654 @default.
• W2131723654 hasPrimaryLocation W21317236541 @default.

• next