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- W2131761696 abstract "Hyperpolarization current ( I f ) is an important player in controlling heart rate and is stimulated by cAMP and inhibited by members of the pertussis toxin-sensitive G-protein G i /G o family. We have successfully derived cardiocytes from embryonic stem cells lacking G o or G i2 and G i3 . We have established that both basal and isoproterenol-stimulated activities of I f in these cardiocytes have typical nodal-atrial characteristics and are unaffected by targeted gene inactivation of the G proteins G o or G i2 and G i3 . Under basal conditions, both G o and G i are required for muscarinic inhibition of I f activity via a mechanism that involves the generation of nitric oxide, whereas, with prior stimulation by β-agonists, only G o is required and G i and nitric oxide production are not. Our findings establish an essential role for G o in the antiadrenergic effect of muscarinic agent on I f ." @default.
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- W2131761696 date "2008-02-01" @default.
- W2131761696 modified "2023-10-18" @default.
- W2131761696 title "Go controls the hyperpolarization-activated current in embryonic stem cell-derived cardiocytes" @default.
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- W2131761696 doi "https://doi.org/10.1152/ajpheart.00293.2007" @default.
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