FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2131787905> ?p ?o ?g. }

• W2131787905 endingPage "623" @default.
• W2131787905 startingPage "605" @default.
• W2131787905 abstract "Abstract The binding activities of the 170 kDa and the 180 kDa human topoisomerases II (topo IIa and topo IIβ) to linear DNA fragments with different degrees of curvature were characterized. In gel retardation experiments it was shown that both forms of the enzyme bind preferentially to a curved 287 bp fragment, forming a detectable stable complex. The affinity for straight DNA fragments of similar length is significantly lower. Both a commercially available topo IIa, isolated from placenta, and topo IIα and topo IIβ purified from nuclear extracts of the Namahva lymphoma tissue culture line gave similar results. The effects of double-stranded poly[d(A-T)], poly[d(G-C)], supercoiled plasmid DNA and linear Z-DNA on the topo II- complex with curved DNA were analyzed in competition experiments. The hierarchy of affinities of the 180 kDa topo IIβ for these DNAs has the order: linear left-handed DNA > supercoiled DNA ⩾ curved DNA ≫ poly[d(A-T)] ⩾ poly[d(G-C)]. The 170 kDa topo IIa binds with similar affinity to curved DNA and linear Z-DNA ⩾ supercoiled DNA ≫ linear B- DNA The data imply that human topoisomerase II binding is more sensitive to DNA secondary structure than to DNA sequence per se. The ability of the enzyme to preferentially recognize a wide variety of sequences in unusual secondary structures suggests a mode of targeting the enzyme in vivo to regions of high negative supercoiling." @default.
• W2131787905 created "2016-06-24" @default.
• W2131787905 creator A5009958441 @default.
• W2131787905 creator A5013564230 @default.
• W2131787905 creator A5078706652 @default.
• W2131787905 date "1994-12-01" @default.
• W2131787905 modified "2023-09-27" @default.
• W2131787905 title "Human 170 kDa and 180 kDa Topoisomerases II Bind Preferentially to Curved and Left-Handed Linear DNA" @default.
• W2131787905 cites W12952247 @default.
• W2131787905 cites W1526379338 @default.
• W2131787905 cites W1555824034 @default.
• W2131787905 cites W1559647740 @default.
• W2131787905 cites W1575065817 @default.
• W2131787905 cites W1899069890 @default.
• W2131787905 cites W1971906849 @default.
• W2131787905 cites W1974089947 @default.
• W2131787905 cites W1978161781 @default.
• W2131787905 cites W1978454774 @default.
• W2131787905 cites W1979768443 @default.
• W2131787905 cites W1979936660 @default.
• W2131787905 cites W1988294814 @default.
• W2131787905 cites W2002191368 @default.
• W2131787905 cites W2005446040 @default.
• W2131787905 cites W2005947159 @default.
• W2131787905 cites W2008249338 @default.
• W2131787905 cites W2016253703 @default.
• W2131787905 cites W2021136272 @default.
• W2131787905 cites W2026072303 @default.
• W2131787905 cites W2029533612 @default.
• W2131787905 cites W2033553519 @default.
• W2131787905 cites W2044427718 @default.
• W2131787905 cites W2046038196 @default.
• W2131787905 cites W2050133761 @default.
• W2131787905 cites W2051664964 @default.
• W2131787905 cites W2052759356 @default.
• W2131787905 cites W2066341116 @default.
• W2131787905 cites W2073281700 @default.
• W2131787905 cites W2074651320 @default.
• W2131787905 cites W2078779065 @default.
• W2131787905 cites W2088701644 @default.
• W2131787905 cites W2088937711 @default.
• W2131787905 cites W2092957736 @default.
• W2131787905 cites W2094321494 @default.
• W2131787905 cites W2096065245 @default.
• W2131787905 cites W2217532849 @default.
• W2131787905 cites W4233567369 @default.
• W2131787905 cites W43816515 @default.
• W2131787905 doi "https://doi.org/10.1080/07391102.1994.10508762" @default.
• W2131787905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7727061" @default.
• W2131787905 hasPublicationYear "1994" @default.
• W2131787905 type Work @default.
• W2131787905 sameAs 2131787905 @default.
• W2131787905 citedByCount "28" @default.
• W2131787905 countsByYear W21317879052015 @default.
• W2131787905 countsByYear W21317879052023 @default.
• W2131787905 crossrefType "journal-article" @default.
• W2131787905 hasAuthorship W2131787905A5009958441 @default.
• W2131787905 hasAuthorship W2131787905A5013564230 @default.
• W2131787905 hasAuthorship W2131787905A5078706652 @default.
• W2131787905 hasConcept C104317684 @default.
• W2131787905 hasConcept C147897179 @default.
• W2131787905 hasConcept C153911025 @default.
• W2131787905 hasConcept C158456008 @default.
• W2131787905 hasConcept C181199279 @default.
• W2131787905 hasConcept C185592680 @default.
• W2131787905 hasConcept C5179208 @default.
• W2131787905 hasConcept C552990157 @default.
• W2131787905 hasConcept C55493867 @default.
• W2131787905 hasConcept C71240020 @default.
• W2131787905 hasConcept C73573662 @default.
• W2131787905 hasConcept C77122620 @default.
• W2131787905 hasConcept C86339819 @default.
• W2131787905 hasConcept C86803240 @default.
• W2131787905 hasConcept C94966510 @default.
• W2131787905 hasConceptScore W2131787905C104317684 @default.
• W2131787905 hasConceptScore W2131787905C147897179 @default.
• W2131787905 hasConceptScore W2131787905C153911025 @default.
• W2131787905 hasConceptScore W2131787905C158456008 @default.
• W2131787905 hasConceptScore W2131787905C181199279 @default.
• W2131787905 hasConceptScore W2131787905C185592680 @default.
• W2131787905 hasConceptScore W2131787905C5179208 @default.
• W2131787905 hasConceptScore W2131787905C552990157 @default.
• W2131787905 hasConceptScore W2131787905C55493867 @default.
• W2131787905 hasConceptScore W2131787905C71240020 @default.
• W2131787905 hasConceptScore W2131787905C73573662 @default.
• W2131787905 hasConceptScore W2131787905C77122620 @default.
• W2131787905 hasConceptScore W2131787905C86339819 @default.
• W2131787905 hasConceptScore W2131787905C86803240 @default.
• W2131787905 hasConceptScore W2131787905C94966510 @default.
• W2131787905 hasIssue "3" @default.
• W2131787905 hasLocation W21317879051 @default.
• W2131787905 hasLocation W21317879052 @default.
• W2131787905 hasOpenAccess W2131787905 @default.
• W2131787905 hasPrimaryLocation W21317879051 @default.
• W2131787905 hasRelatedWork W1969303865 @default.
• W2131787905 hasRelatedWork W1977392864 @default.
• W2131787905 hasRelatedWork W2064175645 @default.
• W2131787905 hasRelatedWork W2081747849 @default.

• next