Matches in SemOpenAlex for { <https://semopenalex.org/work/W2131798343> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2131798343 endingPage "623" @default.
- W2131798343 startingPage "618" @default.
- W2131798343 abstract "The polyacetylene falcarinol, isolated from carrots, has been shown to be protective against chemically induced colon cancer development in rats, but the mechanisms are not fully understood. In this study CaCo-2 cells were exposed to falcarinol (0.5-100 microM) and the effects on proliferation, DNA damage, and apoptosis investigated. Low-dose falcarinol exposure (0.5-10 microM) decreased expression of the apoptosis indicator caspase-3 concomitantly with decreased basal DNA strand breakage. Cell proliferation was increased (1-10 microM), whereas cellular attachment was unaffected by <10 microM falcarinol. At concentrations above 20 microM falcarinol, proliferation of CaCo-2 cells decreased and the number of cells expressing active caspase-3 increased simultaneously with increased cell detachment. Furthermore, DNA single-strand breakage was significantly increased at concentrations above 10 microM falcarinol. Thus, the effects of falcarinol on CaCo-2 cells appear to be biphasic, inducing pro-proliferative and apoptotic characteristics at low and high concentrations of falcarinol, respectively." @default.
- W2131798343 created "2016-06-24" @default.
- W2131798343 creator A5027413498 @default.
- W2131798343 creator A5036642838 @default.
- W2131798343 creator A5054720012 @default.
- W2131798343 creator A5055479107 @default.
- W2131798343 creator A5072420987 @default.
- W2131798343 creator A5090609545 @default.
- W2131798343 date "2007-01-11" @default.
- W2131798343 modified "2023-10-14" @default.
- W2131798343 title "Biphasic Effect of Falcarinol on CaCo-2 Cell Proliferation, DNA Damage, and Apoptosis" @default.
- W2131798343 cites W1569376754 @default.
- W2131798343 cites W1872501262 @default.
- W2131798343 cites W1983393161 @default.
- W2131798343 cites W1986736916 @default.
- W2131798343 cites W1987356934 @default.
- W2131798343 cites W1995524546 @default.
- W2131798343 cites W1999760275 @default.
- W2131798343 cites W2014707536 @default.
- W2131798343 cites W2036757621 @default.
- W2131798343 cites W2054670615 @default.
- W2131798343 cites W2073618991 @default.
- W2131798343 cites W2076429988 @default.
- W2131798343 cites W2088497281 @default.
- W2131798343 cites W2151379494 @default.
- W2131798343 cites W2317242858 @default.
- W2131798343 cites W2325535264 @default.
- W2131798343 cites W4237364480 @default.
- W2131798343 doi "https://doi.org/10.1021/jf0616154" @default.
- W2131798343 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17263451" @default.
- W2131798343 hasPublicationYear "2007" @default.
- W2131798343 type Work @default.
- W2131798343 sameAs 2131798343 @default.
- W2131798343 citedByCount "51" @default.
- W2131798343 countsByYear W21317983432012 @default.
- W2131798343 countsByYear W21317983432013 @default.
- W2131798343 countsByYear W21317983432014 @default.
- W2131798343 countsByYear W21317983432015 @default.
- W2131798343 countsByYear W21317983432016 @default.
- W2131798343 countsByYear W21317983432017 @default.
- W2131798343 countsByYear W21317983432018 @default.
- W2131798343 countsByYear W21317983432019 @default.
- W2131798343 countsByYear W21317983432020 @default.
- W2131798343 countsByYear W21317983432021 @default.
- W2131798343 countsByYear W21317983432022 @default.
- W2131798343 countsByYear W21317983432023 @default.
- W2131798343 crossrefType "journal-article" @default.
- W2131798343 hasAuthorship W2131798343A5027413498 @default.
- W2131798343 hasAuthorship W2131798343A5036642838 @default.
- W2131798343 hasAuthorship W2131798343A5054720012 @default.
- W2131798343 hasAuthorship W2131798343A5055479107 @default.
- W2131798343 hasAuthorship W2131798343A5072420987 @default.
- W2131798343 hasAuthorship W2131798343A5090609545 @default.
- W2131798343 hasConcept C143425029 @default.
- W2131798343 hasConcept C1491633281 @default.
- W2131798343 hasConcept C153911025 @default.
- W2131798343 hasConcept C185592680 @default.
- W2131798343 hasConcept C190283241 @default.
- W2131798343 hasConcept C193176779 @default.
- W2131798343 hasConcept C31573885 @default.
- W2131798343 hasConcept C552990157 @default.
- W2131798343 hasConcept C55493867 @default.
- W2131798343 hasConcept C62112901 @default.
- W2131798343 hasConcept C86803240 @default.
- W2131798343 hasConceptScore W2131798343C143425029 @default.
- W2131798343 hasConceptScore W2131798343C1491633281 @default.
- W2131798343 hasConceptScore W2131798343C153911025 @default.
- W2131798343 hasConceptScore W2131798343C185592680 @default.
- W2131798343 hasConceptScore W2131798343C190283241 @default.
- W2131798343 hasConceptScore W2131798343C193176779 @default.
- W2131798343 hasConceptScore W2131798343C31573885 @default.
- W2131798343 hasConceptScore W2131798343C552990157 @default.
- W2131798343 hasConceptScore W2131798343C55493867 @default.
- W2131798343 hasConceptScore W2131798343C62112901 @default.
- W2131798343 hasConceptScore W2131798343C86803240 @default.
- W2131798343 hasIssue "3" @default.
- W2131798343 hasLocation W21317983431 @default.
- W2131798343 hasLocation W21317983432 @default.
- W2131798343 hasOpenAccess W2131798343 @default.
- W2131798343 hasPrimaryLocation W21317983431 @default.
- W2131798343 hasRelatedWork W2029991552 @default.
- W2131798343 hasRelatedWork W2066489051 @default.
- W2131798343 hasRelatedWork W2134115440 @default.
- W2131798343 hasRelatedWork W2371951337 @default.
- W2131798343 hasRelatedWork W2380755462 @default.
- W2131798343 hasRelatedWork W2471519923 @default.
- W2131798343 hasRelatedWork W2755853517 @default.
- W2131798343 hasRelatedWork W3148810057 @default.
- W2131798343 hasRelatedWork W3150682115 @default.
- W2131798343 hasRelatedWork W3152233030 @default.
- W2131798343 hasVolume "55" @default.
- W2131798343 isParatext "false" @default.
- W2131798343 isRetracted "false" @default.
- W2131798343 magId "2131798343" @default.
- W2131798343 workType "article" @default.