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- W2131804390 abstract "Raynaud's disease isuncommoninchildren. Thepatient described heredeveloped Raynaud's disease subsequent torubella whenshewas7years old.Treatment withgriseofulvin brought about arapid disappearance ofthesymptomsandsigns. CaseHistory Thepatient, a7-year-old girl, withnoprevious history ofcirculatory disorder, developed rubella, andaweek later a discoloration ofherfingers wasnoted.The indexfinger oftheright handbecamepurple andcold andthentheindexfinger ofherleft handbecame similarly affected. Otherfingers weresooninvolved (see Fig.) andbythethird weeksomediscoloration ofthe toeswasnoticed. Therewasnofamily history ofany similar disorder. Onexamination atthattimeshewasahealthy-looking girl ofaverage build.Thecirculatory changes described abovewerefound, involving mainly thefingers. A trophic lesion waspresent atthetipoftheright index finger. Thetoeswereinvolved, buttoalesser extent. Arterial pulses inthelimbs werenormal; blood pressure 90/60 mm. Hg. Theskin wasmildly ichthyotic. Investigations. Hb,whitebloodcount, anddifferential, normal;platelets, 115,000/mm.3 Rubella neutralizing antibody titre, 1/32; antinuclear protein factor, negative. Coldhaemagglutinins (taken and separated at370C.), negative; cryoglobulins (taken and separated at370C.), negative; serumproteins, 7 0%; albumin, 5*0%,globulin, 2*0%.Serumimmunoelectrophoresis, IgA,140mg./100 ml.;IgG,1800mg./ 100ml.;IgM,80mg./100 ml., allnormalforthis age. Digital pulptemperatures (Table) implied ischaemia except fortheringfinger andthumbofbothhands. Plethysmographic measurementoftotal handblood flowwas10ml./100 ml.ofhandtissue permin.(adult values at340C.arenormally 30ml./100 ml.ofhand tissue perminute(Wade,1965)). Therewasa good hyperaemic response tolocal warming ofthedigits. After 5weeksofincreasing circulatory disorder, oral treatment wasstarted withfineparticle griseofulvin, 125mg.b.d.A subjective improvement wasnoticed after 3days.After 2weeksoftreatment theinfection aroundthefinger-nails haddisappeared andthey were" @default.
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- W2131804390 date "1968-06-01" @default.
- W2131804390 modified "2023-09-26" @default.
- W2131804390 title "Raynaud's disease treated with griseofulvin." @default.
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- W2131804390 doi "https://doi.org/10.1136/adc.43.229.344" @default.
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