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• W2131845264 abstract "Breast cancer in younger patients often presents with adverse histopathological features, including increased frequency of estrogen receptor negative and lymph node positive disease status. Chromosomal instability (CIN) is increasingly recognised as an important prognostic variable in solid tumours. In a breast cancer meta-analysis of 2423 patients we examine the relationship between clinicopathological parameters and two distinct chromosomal instability gene expression signatures in order to address whether younger age at diagnosis is associated with increased tumour genome instability. We find that CIN, assessed by the two independently derived CIN expression signatures, is significantly associated with increased tumour size, ER negative or HER2 positive disease, higher tumour grade and younger age at diagnosis in ER negative breast cancer. These data support the hypothesis that chromosomal instability may be a defining feature of breast cancer biology and clinical outcome." @default.
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• W2131845264 date "2011-06-25" @default.
• W2131845264 modified "2023-10-14" @default.
• W2131845264 title "A breast cancer meta-analysis of two expression measures of chromosomal instability reveals a relationship with younger age at diagnosis and high risk histopathological variables" @default.
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• W2131845264 doi "https://doi.org/10.18632/oncotarget.298" @default.
• W2131845264 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3248181" @default.
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• W2131845264 hasPublicationYear "2011" @default.
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