FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2131850891> ?p ?o ?g. }

• W2131850891 endingPage "i129" @default.
• W2131850891 startingPage "i122" @default.
• W2131850891 abstract "Abstract Motivation: Transmembrane (TM) proteins that form α-helix bundles constitute approximately 50% of contemporary drug targets. Yet, it is difficult to determine their high-resolution (&lt; 4 Å) structures. Some TM proteins yield more easily to structure determination using cryo electron microscopy (cryo-EM), though this technique most often results in lower resolution structures, precluding an unambiguous assignment of TM amino acid sequences to the helices seen in the structure. We present computational tools for assigning the TM segments in the protein's sequence to the helices seen in cryo-EM structures. Results: The method examines all feasible TM helix assignments and ranks each one based on a score function that was derived from loops in the structures of soluble α-helix bundles. A set of the most likely assignments is then suggested. We tested the method on eight TM chains of known structures, such as bacteriorhodopsin and the lactose permease. Our results indicate that many assignments can be rejected at the outset, since they involve the connection of pairs of remotely placed TM helices. The correct assignment received a high score, and was ranked highly among the remaining assignments. For example, in the lactose permease, which contains 12 TM helices, most of which are connected by short loops, only 12 out of 479 million assignments were found to be feasible, and the native one was ranked first. Availability: The program and the non-redundant set of protein structures used here are available at http://www.cs.tau.ac.il/~angela" @default.
• W2131850891 created "2016-06-24" @default.
• W2131850891 creator A5025089277 @default.
• W2131850891 creator A5031768744 @default.
• W2131850891 creator A5037671858 @default.
• W2131850891 creator A5038503253 @default.
• W2131850891 date "2004-08-04" @default.
• W2131850891 modified "2023-09-26" @default.
• W2131850891 title "Assigning transmembrane segments to helices in intermediate-resolution structures" @default.
• W2131850891 cites W1510774549 @default.
• W2131850891 cites W1972868248 @default.
• W2131850891 cites W1993022573 @default.
• W2131850891 cites W1994373739 @default.
• W2131850891 cites W2008708467 @default.
• W2131850891 cites W2018562664 @default.
• W2131850891 cites W2026976121 @default.
• W2131850891 cites W2027711565 @default.
• W2131850891 cites W2034410027 @default.
• W2131850891 cites W2037846060 @default.
• W2131850891 cites W2045994733 @default.
• W2131850891 cites W2047163848 @default.
• W2131850891 cites W2063044149 @default.
• W2131850891 cites W2063249275 @default.
• W2131850891 cites W2065509725 @default.
• W2131850891 cites W2067484689 @default.
• W2131850891 cites W2074182813 @default.
• W2131850891 cites W2118259597 @default.
• W2131850891 cites W2123530749 @default.
• W2131850891 cites W2149906774 @default.
• W2131850891 cites W2152582781 @default.
• W2131850891 cites W2155147384 @default.
• W2131850891 cites W2160535028 @default.
• W2131850891 cites W2166110558 @default.
• W2131850891 doi "https://doi.org/10.1093/bioinformatics/bth939" @default.
• W2131850891 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15262790" @default.
• W2131850891 hasPublicationYear "2004" @default.
• W2131850891 type Work @default.
• W2131850891 sameAs 2131850891 @default.
• W2131850891 citedByCount "14" @default.
• W2131850891 countsByYear W21318508912012 @default.
• W2131850891 countsByYear W21318508912013 @default.
• W2131850891 countsByYear W21318508912014 @default.
• W2131850891 countsByYear W21318508912020 @default.
• W2131850891 crossrefType "journal-article" @default.
• W2131850891 hasAuthorship W2131850891A5025089277 @default.
• W2131850891 hasAuthorship W2131850891A5031768744 @default.
• W2131850891 hasAuthorship W2131850891A5037671858 @default.
• W2131850891 hasAuthorship W2131850891A5038503253 @default.
• W2131850891 hasConcept C115335371 @default.
• W2131850891 hasConcept C118892022 @default.
• W2131850891 hasConcept C138268822 @default.
• W2131850891 hasConcept C144647389 @default.
• W2131850891 hasConcept C154945302 @default.
• W2131850891 hasConcept C170493617 @default.
• W2131850891 hasConcept C177264268 @default.
• W2131850891 hasConcept C185592680 @default.
• W2131850891 hasConcept C18903297 @default.
• W2131850891 hasConcept C189542057 @default.
• W2131850891 hasConcept C199360897 @default.
• W2131850891 hasConcept C24530287 @default.
• W2131850891 hasConcept C2778112365 @default.
• W2131850891 hasConcept C2778530040 @default.
• W2131850891 hasConcept C2779965526 @default.
• W2131850891 hasConcept C41008148 @default.
• W2131850891 hasConcept C41625074 @default.
• W2131850891 hasConcept C47701112 @default.
• W2131850891 hasConcept C515207424 @default.
• W2131850891 hasConcept C55493867 @default.
• W2131850891 hasConcept C58598135 @default.
• W2131850891 hasConcept C8010536 @default.
• W2131850891 hasConcept C86803240 @default.
• W2131850891 hasConceptScore W2131850891C115335371 @default.
• W2131850891 hasConceptScore W2131850891C118892022 @default.
• W2131850891 hasConceptScore W2131850891C138268822 @default.
• W2131850891 hasConceptScore W2131850891C144647389 @default.
• W2131850891 hasConceptScore W2131850891C154945302 @default.
• W2131850891 hasConceptScore W2131850891C170493617 @default.
• W2131850891 hasConceptScore W2131850891C177264268 @default.
• W2131850891 hasConceptScore W2131850891C185592680 @default.
• W2131850891 hasConceptScore W2131850891C18903297 @default.
• W2131850891 hasConceptScore W2131850891C189542057 @default.
• W2131850891 hasConceptScore W2131850891C199360897 @default.
• W2131850891 hasConceptScore W2131850891C24530287 @default.
• W2131850891 hasConceptScore W2131850891C2778112365 @default.
• W2131850891 hasConceptScore W2131850891C2778530040 @default.
• W2131850891 hasConceptScore W2131850891C2779965526 @default.
• W2131850891 hasConceptScore W2131850891C41008148 @default.
• W2131850891 hasConceptScore W2131850891C41625074 @default.
• W2131850891 hasConceptScore W2131850891C47701112 @default.
• W2131850891 hasConceptScore W2131850891C515207424 @default.
• W2131850891 hasConceptScore W2131850891C55493867 @default.
• W2131850891 hasConceptScore W2131850891C58598135 @default.
• W2131850891 hasConceptScore W2131850891C8010536 @default.
• W2131850891 hasConceptScore W2131850891C86803240 @default.
• W2131850891 hasIssue "suppl_1" @default.
• W2131850891 hasLocation W21318508911 @default.
• W2131850891 hasLocation W21318508912 @default.
• W2131850891 hasOpenAccess W2131850891 @default.

• next